Results 61 to 70 of about 24,553 (208)

Drug Design and Delivery for Intracellular Bacteria: Emerging Paradigms

Drug Development Research, Volume 86, Issue 8, December 2025.
ABSTRACT Intracellular bacteria exploit host cell niches, such as lysosomes, phagosomes, cytosol, entire cells, and even erythrocytes, to evade immune clearance and escape conventional antibiotics. These environments pose numerous therapeutic challenges, including crossing host cell membranes, navigating endosomal trafficking, tolerating acidic and ...
Babatunde Ibrahim Olowu, Maryam Ebunoluwa Zakariya, Abdulmuheez Abiola Abdulkareem, Olalekan Toheeb Okewale, Muhammad Halima Idris, Halimah Oluwayemisi Olayiwola   +5 more
wiley   +1 more source

The interplay between tissue‐resident microbiome and host proteins by integrated multi‐omics during progression of colorectal adenoma to carcinoma

iMeta, Volume 4, Issue 6, December 2025.
This study integrated metagenomic and proteomic profiling of 185 colorectal tissue samples—spanning adenoma (A), tumor (T), and para‐tumor (P)—to characterize multi‐kingdom microbiome and host protein dynamics in colorectal cancer (CRC). In total, 4057 bacterial, 61 fungal, 108 archaeal, and 374 viral species were identified, revealing CRC‐specific ...
Di Wu, An‐Jun Wang, De‐Chao Bu, Yan‐Yan Sun, Chen‐Hao Li, Yue‐Mei Hong, Shan Zhang, Shi‐Yang Chen, Jin‐An Zhou, Tian‐Yi Zhang, Min‐Hao Yu, Yong‐Jing Ma, Xiu‐Li Wang, Jia Xu, Wei He, Christopher Heeschen, Jian‐Feng Chen, Wen‐Jun Mao, Hui Ding, Wen‐Juan Wu, Yi Zhao, Hui Wang, Ning‐Ning Liu   +22 more
wiley   +1 more source

VirB4- and VirD4-like ATPases, components of a putative type 4C secretion system in Clostridioides difficile [PDF]

, 2021
Julya Sorokina, И. А. Соколова, Ivan Rybolovlev, Natalya Shevlyagina, Vasiliy Troitskiy, V. G. Zhukhovitsky, Yury Belyi   +6 more
openalex   +1 more source

Quantification of Clostridioides (Clostridium) difficile in feces of calves of different age and determination of predominant Clostridioides difficile ribotype 033 relatedness and transmission between family dairy farms using multilocus variable-number tandem-repeat analysis

BMC Veterinary Research, 2018
Background Community acquired Clostridioides (Clostridium) difficile infection (CA-CDI) is a significant health problem in human and veterinary medicine. Animals are often considered as potential reservoirs for CA-CDI.
Petra Bandelj, Céline Harmanus, Rok Blagus, Marko Cotman, Ed J. Kuijper, Matjaz Ocepek, Modest Vengust   +6 more
doaj   +1 more source

Whole microbiota transplantation restores gut homeostasis throughout the gastrointestinal tract

iMeta, Volume 4, Issue 6, December 2025.
This study introduces whole microbiota transplantation (WMT), a synergistic therapeutic approach that concurrently transplants small intestinal and fecal microbiota. In germ‐free mice, WMT outperforms conventional fecal microbiota transplantation (FMT) in restoring gut microbiota diversity and abundance.
Bufu Tang, Yuan Cao, Jiasu Li, Nan Gao, Pingting Gao, Xiaochao Chen, Zunzhen Ming, Zhaoshen Li, Weiliang Hou   +8 more
wiley   +1 more source

Extracellular Vesicles in Nonalcoholic Fatty Liver Disease: Mechanisms and Therapeutic Opportunities

iNew Medicine, Volume 1, Issue 1, December 2025.
The role of extracellular vesicles (EVs) in the progression of nonalcoholic fatty liver disease (NAFLD). Donor cells release EVs containing various molecules such as cholesterol, ceramide, sphingomyelin, miRNA, DNA, proteins, and lipids. These EVs are taken up by multiple recipient cells including Kupffer cells, adipocytes, β cells, adipose tissue ...
Yunsheng Dong, Lei Xiong, Nina Zhu, Zihan Wang, Hanqi Xia, Chen Cheng, Jianshang Huang, Yiran Han, Abduxukur Rahman, Junhao Zhao, Chonggui Jiang, Li Zuo, Hua Wang   +12 more
wiley   +1 more source

Clostridioides difficile co-infection with Enterohemorrhagic Escherichia coli (EHEC)—a potentially fatal combination

IDCases, 2020
There has been a significant increase in hospital and community acquired Clostridioides difficile infection in the past decade. In addition to CDI, the rate of infection with enterohemorrhagic Escherichia coli (EHEC) has also increased by 28% in United ...
Farah Deshmukh, Upasana Agrawal, Nancy Merrell   +2 more
doaj   +1 more source

Next‐Generation Sequencing in Infectious‐Disease Diagnostics: Economic, Regulatory, and Clinical Pathways to Adoption

MicrobiologyOpen, Volume 14, Issue 6, December 2025.
Next‐generation sequencing (NGS) is poised to transform infectious‐disease diagnostics. Falling per‐sample costs, new CPT codes and FDA pathways, and 24‐h, multiplexed resistome reports converge to deliver faster, evidence‐based therapy and stronger surveillance. Our roadmap links the economic, regulatory, and clinical pillars to accelerate routine NGS
John Osei Sekyere
wiley   +1 more source

The Role of Machine Learning in Addressing Antibiotic Resistance: A New Era in Infectious Disease Control

MicrobiologyOpen, Volume 14, Issue 6, December 2025.
Artificial intelligence accelerates the discovery of new antibiotics by rapidly analyzing vast chemical libraries to combat antimicrobial resistance effectively. AI systems predict antibiotic resistance trends, helping researchers design targeted therapies, and prevent the spread of multidrug‐resistant infections. ABSTRACT Antimicrobial resistance (AMR)
Akmal Zubair, Mohd Fazil, Muhammad Jawad, Safa Wdidi   +3 more
wiley   +1 more source

Epidemiological characteristics of infections caused by bacteria Clostridioides difficile toxins [PDF]

Srpski Arhiv za Celokupno Lekarstvo
Introduction/Objective. Clostridioides difficile is one of the most common infectious agents and an important cause of infections among hospitalized patients, often resulting in severe and potentially fatal outcomes.
Koprivica Marko, Đekić-Malbaša Jelena
doaj   +1 more source