Results 81 to 90 of about 32,937 (264)

Clostridioides difficile infection in a long-term convalescence hospital: A real tale of pitfalls and outdated therapy [PDF]

, 2021
Objective. The aim of the study was to know the char-acteristics and risk factors of Clostridioides difficile infection (CDI) in a long-term hospital is key to improve its manage-ment. Material and methods.
Esteban-Rihuete, M., García-Forcada, Á., García-Herrero, J.C., García-Lechuz, J.M., Moreno-Borraz, L., Rodríguez-Gascón, D.   +5 more
core   +1 more source

Synthetic Biology‐Based Engineering Living Therapeutics for Antimicrobial Application

Exploration, EarlyView.
This perspective highlights synthetic biology‐driven antibacterial strategies, focusing on three innovative approaches: engineered bacteriophages for precision bacterial targeting, reprogrammed microbes that detect quorum‐sensing signals or metabolites to release antimicrobials, and engineering mammalian cells that recognize pathogen‐associated ...
Shun Huang, Shuihao Zhao, Haijie Zhao, Mingzhang Wen, Zhong Guo   +4 more
wiley   +1 more source

Impact of ribotype on Clostridioides difficile diagnostics [PDF]

European Journal of Clinical Microbiology & Infectious Diseases, 2019
AbstractThis study investigates the performance of diagnostic methods for detection of Clostridioides difficile infection in Sweden, including impact of PCR ribotype on diagnostic performance. Between 2011 and 2016, a total of 17,878 stool samples from 26 laboratories were tested by either well-type enzyme immunoassays (EIAs), membrane bound EIAs, cell
Kristina Rizzardi, Andreas Matussek, Thomas Åkerlund, Torbjörn Norén   +3 more
openaire   +3 more sources

Expanding Our Grasp of Two-Component Signaling in \u3ci\u3eClostridioides difficile\u3c/i\u3e [PDF]

, 2023
The intestinal pathogen Clostridioides difficile encodes roughly 50 TCS, but very few have been characterized in terms of their activating signals or their regulatory roles. A. G. Pannullo, B. R. Zbylicki, and C. D. Ellermeier (J Bacteriol 205:e00164-23,
Alvarez, Orlando Berumen, Purcell, Erin B.   +1 more
core   +1 more source

Gut microbiota and tuberculosis

iMeta, EarlyView.
This review explores the intricate relationship between gut microbiota (GM) and tuberculosis (TB). The figure illustrates the bidirectional effects between GM dynamics and TB progression, as well as the interactions between the GM and antituberculosis drugs.
Yanhua Liu, Ling Yang, Maryam Meskini, Anjana Goel, Monique Opperman, Sagar Singh Shyamal, Ajay Manaithiya, Meng Xiao, Ruizi Ni, Yajing An, Mingming Zhang, Yuan Tian, Shuang Zhou, Zhaoyang Ye, Li Zhuang, Linsheng Li, Istuti Saraswat, Ankita Kar, Syed Luqman Ali, Shakir Ullah, Syed Yasir Ali, Shradha Kaushik, Tianmu Tian, Mingyang Jiao, Shujun Wang, Giulia Ghisleni, Alice Armanni, Sara Fumagalli, WenYu Wang, Chao Cao, Maria Carpena, Miguel A. Prieto, Antonia Bruno, Chanyuan Jin, Hanqing Hu, Yuhang Zhang, Ilse du Preez, Ashok Aspatwar, Lingxia Zhang, Wenping Gong   +39 more
wiley   +1 more source

Modeling inpatient and outpatient antibiotic stewardship interventions to reduce the burden of Clostridioides difficile infection in a regional healthcare network [PDF]

, 2020
Antibiotic exposure can lead to unintended outcomes, including drug-drug interactions, adverse drug events, and healthcare-associated infections like Clostridioides difficile infection (CDI). Improving antibiotic use is critical to reduce an individual's
Bobashev, G., CDC MInD-Healthcare Network, DiBiase, L., Endres-Dighe, S., Hilscher, R., Jones, K., Lewis, J., MacFarquhar, J., Marx, A., Munoz, B., Rhea, S., Rineer, J., Sickbert-Bennett, E., Weber, D.J.   +13 more
core   +2 more sources

An Osmotic Laxative Renders Mice Susceptible to Prolonged Clostridioides difficile Colonization and Hinders Clearance

mSphere, 2021
Diarrheal samples from patients taking laxatives are typically rejected for Clostridioides difficileC ...
Sarah Tomkovich, Ana Taylor, Jacob King, Joanna Colovas, Lucas Bishop, Kathryn McBride, Sonya Royzenblat, Nicholas A. Lesniak, Ingrid L. Bergin, Patrick D. Schloss   +9 more
doaj   +1 more source

An incidental finding of mesenteric hematoma in a patient with a new diagnosis of inflammatory bowel disease

JPGN Reports, EarlyView.
Abstract Mesenteric hematomas (MHs) are relatively rare and are characterized by localized bleeding in the mesenteric vascular tree presenting with abdominal pain, vomiting, abdominal distension, masses, and hypotension. We report a case of a MH which was incidentally found in a 10‐year‐old patient with a new diagnosis of ulcerative colitis (UC).
Breanna Brown, Anna Hunter, Kimberly Trieschmann   +2 more
wiley   +1 more source

Protection from Lethal Clostridioides difficile Infection via Intraspecies Competition for Cogerminant

mBio, 2021
Antibiotic-associated colitis is often caused by infection with the bacterium Clostridioides difficileC ...
Jhansi L. Leslie, Matthew L. Jenior, Kimberly C. Vendrov, Alexandra K. Standke, Madeline R. Barron, Tricia J. O’Brien, Lavinia Unverdorben, Pariyamon Thaprawat, Ingrid L. Bergin, Patrick D. Schloss, Vincent B. Young   +10 more
doaj   +1 more source

Bezlotoxumab as Treatment for Recurrent/Chronic Clostridioides difficile Infection in Pediatric Stem Cell Transplant Recipients: A Multi‐Institutional Experience

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Clostridioides difficile infection (CDI) represents a significant health risk to pediatric stem cell transplant (SCT) patients. In these patients, recurrent CDI is common, requiring prolonged antibiotic usage and increased hospitalization. Bezlotoxumab, a monoclonal antibody that targets the toxin responsible for CDI, has demonstrated efficacy
Aaron E. Fan, Shaikha Alqahtani, Natalie Dailey Garnes, Priti Tewari, Demetrios Petropoulos, Sajad Khazal, Kris Mahadeo, Paige DePriest, Irtiza N. Sheikh   +8 more
wiley   +1 more source