Results 1 to 10 of about 44,840 (262)

Engineering probiotics to inhibit Clostridioides difficile infection by dynamic regulation of intestinal metabolism

Nature Communications, 2022
Clostridioides difficile infection (CDI) results in significant morbidity and mortality in hospitalised patients. Here the authors engineer probiotics to restore intestinal bile salt metabolism in response to antibiotic-induced microbiome dysbiosis ...
Elvin Koh, In Young Hwang, Hui Ling Lee, Ryan De Sotto, Jonathan Wei Jie Lee, Yung Seng Lee, John C. March, Matthew Wook Chang   +7 more
doaj   +2 more sources

Extraintestinal Clostridioides difficile infection

IDCases, 2020
Clostridioides (Clostridium) difficile is the major cause of healthcare antibiotic-associated diarrhoea. However, extra-intestinal manifestations of Clostridioides (Clostridium) difficile infection (CDI) (including bacteremia and tissue infection) are ...
Zhao Hai, Lei Peng Zhen, Ma Juan, Yang Fan, Cang Jin Rong, Liang Jing Yao, Zhang Li Xia   +6 more
doaj   +3 more sources

Cutting edges in Clostridioides difficile infections

Swiss Medical Weekly, 2021
Clostridioides difficile is the most common cause of hospital-acquired diarrhoea and one of the most important causes of hospital-acquired infections.
Ana Durovic, Sarah Tschudin-Sutter
doaj   +3 more sources

A Review of Therapies for Clostridioides difficile Infection [PDF]

Antibiotics
Clostridioides difficile is an urgent public health threat that affects approximately half a million patients annually in the United States. Despite concerted efforts aimed at the prevention of Clostridioides difficile infection (CDI), it remains a ...
Faiza Morado, Neha Nanda
doaj   +2 more sources

Epidemiology of community-acquired and recurrent infection

Therapeutic Advances in Gastroenterology, 2021
Clostridioides difficile infection is a leading cause of healthcare-associated infections with significant morbidity and mortality. For the past decade, the bulk of infection prevention and epidemiologic surveillance efforts have been directed toward ...
Yichun Fu, Yuying Luo, Ari M Grinspan
doaj   +2 more sources

Clostridioides difficile infection: an update.

Infezioni in Medicina
Clostridioides difficile (C. difficile) is a Gram-positive, spore-forming anaerobic bacterium emerged as a leading cause of diarrhea globally. CDI's (Clostridioides difficile infection) impact on healthcare systems is concerning due to high treatment ...
Federica Salvati, Francesca Catania, Rita Murri, M. Fantoni, Carlo Torti   +4 more
semanticscholar   +3 more sources

Clostridioides difficile Infection: Diagnosis and Treatment Challenges

Pathogens
Clostridioides difficile is the most important cause of healthcare-associated diarrhea in the United States. The high incidence and recurrence rates of C.
John E Markantonis, John T. Fallon, R. Madan, Md Zahidul Alam   +3 more
semanticscholar   +4 more sources

Risk factors for further recurrences of Clostridioides difficile infection at the first and second recurrence: a retrospective cohort [PDF]

BMC Infectious Diseases
Background Recurrent Clostridioides difficile infection is most effectively treated with faecal microbiota transplantation. Swedish and European guidelines suggest faecal microbiota transplantation after a first or second recurrence, respectively.
Måns Stefansson, Oscar Bladh, Piotr Nowak, Lars Rombo, Magnus Hedenstierna, Johan Ursing   +5 more
doaj   +2 more sources

Editorial: Clostridioides difficile infection

Frontiers in Medicine
Guido Granata, Frédéric Barbut, Nicola Petrosillo   +2 more
doaj   +3 more sources

Clinical Practice Guideline by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA): 2021 Focused Update Guidelines on Management of Clostridioides difficile Infection in Adults.

Clinical Infectious Diseases, 2021
This clinical practice guideline is a focused update on management of Clostridioides difficile infection (CDI) in adults specifically addressing the use of fidaxomicin and bezlotoxumab for the treatment of CDI.
Stuart Johnson, V. Lavergne, Andrew M. Skinner, A. Gonzales-Luna, K. Garey, C. Kelly, M. Wilcox   +6 more
semanticscholar   +2 more sources