Results 61 to 70 of about 1,849,474 (227)

Artificial Intelligence‐Guided Phenotypic Drug Repurposing Against Streptococcus pneumoniae

Advanced Science, EarlyView.
Integrated artificial intelligence (AI) ensembles identify highly potent repurposed drugs against Streptococcus pneumoniae. Prospective virtual screening of 6747 drugs uncovers nine active candidates, including thiostrepton. This drug exhibits low picomolar potency and bypasses established resistance in multidrug‐resistant strains, demonstrating an ...
Joshua S. Fitch, Muhammad D. Ariadi, Min Jung Kwun, Leonie Howells, Saiveth Hernandez‐Hernandez, Nicholas J. Croucher, Pedro J. Ballester   +6 more
wiley   +1 more source

Sex‐ and Time‐Resolved Physiological and Gut Ecosystem Responses to a Food‐Grade Microbiome‐Targeted Intervention in Collegiate Endurance Athletes

Advanced Science, EarlyView.
In collegiate endurance athletes, a 6‐week randomized CPYE intervention yielded time‐ and sex‐dependent shifts in field‐based cardiorespiratory, metabolic, and redox indices, accompanied by changes in gut multi‐omics profiles. An exploratory extension during intensified training generates hypotheses warranting future validation.
Meng Zhang, Le Ge, Kaiyang Liu, Yanrong Liu, Guolin Zhao, Lai‐Yu Kwok, Zheng Sun, Zhihong Sun, Wenyi Zhang   +8 more
wiley   +1 more source

Impact of Postoperative Infectious Complications on Long‐Term Survival After Curative Resection for Colorectal Cancer: A Multicenter Study in the Minimally Invasive Era

Annals of Gastroenterological Surgery, EarlyView.
Postoperative infectious complications (PICs) have been associated with poor long‐term outcomes after colorectal cancer surgery, but evidence in the modern minimally invasive era remains limited. In this multicenter cohort of 5377 patients undergoing curative resection, PICs were independently associated with worse overall survival and relapse‐free ...
Takehito Yamamoto, Ryosuke Mizuno, Yoshiro Itatani, Tetsuya Shiota, Masahiro Yamada, Tadayoshi Yamaura, Mami Yoshitomi, Kazutaka Obama   +7 more
wiley   +1 more source

Clostridioides difficile Infection: A Never-Ending Challenge

, 2022
The most common worldwide cause of antibiotic-associated diarrhea/colitis is the toxin-producing bacterium Clostridioides difficile [...
Petrosillo, Nicola, Nicola Petrosillo
core   +1 more source

Clostridioides difficile infection-free survival during versus before the COVID-19 pandemic.

, 2022
Kaplan Meier curve of Clostridioides difficile infection-free survival pre (2016–2019) and during the COVID-19 pandemic (March 2020-August 2021) after treatment with faecal microbiota transplantation using faecal suspensions provided by the NDFB [7].
Ed J. Kuijper (7378352), Eline Boeije-Koppenol (12256964), Bas Groenewegen (12256955), Els Wessels (9120616), Hein W. Verspaget (12256967), Joffrey van Prehn (10054011), Elisabeth M. Terveer (10537642), Rogier E. Ooijevaar (8613153), Mariet C. W. Feltkamp (12256961), Josbert J. Keller (8613168), Emilie van Lingen (12256958)   +10 more
core   +1 more source

Fecal microbiota transplantation in a patient hospitalized in the intensive care unit – Case report

Heliyon
Clostridioides difficile infections are difficult and serious problem occurring in patients staying in intensive care units. In recent years, the number and severity of these infections, as well as the mortality rate, have been increasing, posing a ...
Katarzyna Oliwa-Libumska, Aleksandra Jaworska-Czerwinska, Malgorzata Mallek-Grabowska, Robert Wlodarski, Przemyslaw Zuratynski, Bartosz Kozlowski   +5 more
doaj   +1 more source

Clostridioides difficile exploits toxin-mediated inflammation to alter the host nutritional landscape and exclude competitors from the gut microbiota

Nature Communications, 2021
The effects of antibiotics on the gut microbiota can lead to enhanced colonization of Clostridioides difficile (C. difficile) and toxin-mediated pathogenesis.
Joshua R. Fletcher, Colleen M. Pike, Ruth J. Parsons, Alissa J. Rivera, Matthew H. Foley, Michael R. McLaren, Stephanie A. Montgomery, Casey M. Theriot   +7 more
doaj   +1 more source

Современные подходы к иммунотерапии инфекции Clostridioides difficile [PDF]

Clostridioides difficile is a leading cause of diarrhea and pseudomembranous colitis associated with antibiotic therapy. Hypervirulent strains of C. difficile, such as ribotype 027, have high mortality rates. Recurrent C. difficile infection is extremely
V. V. Makarov, К. Э. Попруга, K. E. Popruga, В. В. Макаров   +3 more
core   +1 more source

Characterization of the gut microbiome of patients with Clostridioides difficile infection, patients with non–C. difficile diarrhea, and C. difficile–colonized patients

, 2023
Funding: This study was funded by Fondo de Investigaciones Sanitarias (FIS), Research Project number PI16/00490 and PI20/01381, PFIS grant number FI21/00310, and by the European Regional Development Fund (FEDER) “A way of making Europe”.Introduction ...
Vázquez Cuesta, Silvia, Bouza Santiago, Emilio, Villar, Laura, García Lozano, Nuria, Alcalá, Luis, Fernández, Ana I., Muñoz García, Patricia Carmen, Reigadas Ramírez, Elena Manuela, Olmedo, María, Marín Arriaza, María De Las Mercedes   +9 more
core   +1 more source

Incidence of hospital-acquired toxin-producing clostridioides difficile infection between the pre-pandemic (2017–2019) and pandemic (2020–2022): a retrospective cohort study

Archives of Public Health
Background In 2020, the World Health Organization declared SARS-CoV-2 a global public health emergency. Healthcare systems were forced to reorganize care delivery and implement wide-ranging infection control strategies. Among hospital-acquired infections,
Raquel García Rodríguez, María José Pereira Rodríguez, Alejandra Pilar García López, Fabián Freijedo Fariñas, Angela Nogueira Gómez   +4 more
doaj   +1 more source