Results 81 to 90 of about 18,494 (211)

ZupT Facilitates Clostridioides difficile Resistance to Host-Mediated Nutritional Immunity

mSphere, 2020
Clostridioides difficile is a spore-forming bacterium that causes severe colitis and is a major public health threat. During infection, C. difficile toxin production results in damage to the epithelium and a hyperinflammatory response.
Joseph P. Zackular, Reece J. Knippel, Christopher A. Lopez, William N. Beavers, C. Noel Maxwell, Walter J. Chazin, Eric P. Skaar   +6 more
doaj   +1 more source

Retrospective Study of the Epidemiology of Clostridioides difficile Infection in the Neurosurgery Department of a Tertiary Hospital in China

Infection and Drug Resistance, 2023
Xiajing Bi,1 Lisi Zheng,2 Zhi Yang,1 Tao Lv,2 Xiaofei Tong,1 Yunbo Chen2,3 1Department of Neurosurgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, People’s Republic of China; 2State Key Laboratory for Diagnosis and ...
Bi X, Zheng L, Yang Z, Lv T, Tong X, Chen Y   +5 more
doaj  

Structural and functional insight into the interaction of Clostridioides difficile toxin B and FZD7

Cell Reports
Summary: The G protein-coupled receptors of the Frizzled (FZD) family, in particular FZD1,2,7, are receptors that are exploited by Clostridioides difficile toxin B (TcdB), the major virulence factor responsible for pathogenesis associated with ...
Julia Kinsolving, Julien Bous, Pawel Kozielewicz, Sara Košenina, Rawan Shekhani, Lukas Grätz, Geoffrey Masuyer, Yuankai Wang, Pål Stenmark, Min Dong, Gunnar Schulte   +10 more
doaj   +1 more source

Clostridioides difficile Infection: A Never-Ending Challenge

Journal of Clinical Medicine, 2022
The most common worldwide cause of antibiotic-associated diarrhea/colitis is the toxin-producing bacterium Clostridioides difficile [...]
openaire   +2 more sources

Clostridioides (Formerly Clostridium) difficile Infection During Hospitalization Increases the Likelihood of Nonhome Patient Discharge [PDF]

, 2018
Kelly R. Reveles, Kierra M. Dotson, Anne J Gonzales-Luna, Dhara Surati, Bradley T. Endres, Mohammad Jahangir Alam, Kevin W. Garey   +6 more
openalex   +1 more source

Emerging Diagnostics in Clostridioides difficile Infection

International Journal of Molecular Sciences
Clostridioides difficile detection in community settings is time-intensive, resulting in delays in diagnosing and quarantining infected individuals. However, with the advent of semi-automated devices and improved algorithms in recent decades, the ability to discern CDI infection from asymptomatic carriage has significantly improved.
openaire   +2 more sources

Effective fecal microbiota transplantation for recurrent Clostridioides difficile infection in humans is associated with increased signalling in the bile acid-farnesoid X receptor-fibroblast growth factor pathway [PDF]

, 2018
Tanya Monaghan, Benjamin H. Mullish, Jordan Patterson, Gane Ka‐Shu Wong, Julian R. Marchesi, Huiping Xu, Tahseen Jilani, Dina Kao   +7 more
openalex   +1 more source

Risk factors for community-associated Clostridioides difficile infection in young children [PDF]

, 2019
Min Weng, Susan Hocevar Adkins, Wendy Bamberg, Monica M. Farley, Catherine Espinosa, Lucy Wilson, Rebecca Perlmutter, Stacy Holzbauer, Tory Whitten, Erin C. Phipps, Emily Hancock, Ghinwa Dumyati, Deborah Nelson, Zintars G. Beldavs, Valerie Ocampo, Corinne M. Davis, Brenda Rue, Lauren Korhonen, L. Clifford McDonald, Alice Guh   +19 more
openalex   +1 more source

Role of the gut microbiota in Clostridioides difficile Infection

, 2023
Clostridioides difficile infection (CDI) is caused by the anaerobic, spore-forming bacterium C. difficile. In the US there are approximately 500,000 cases of CDI a year and 15,000 deaths. In Scotland, from 2011-2020 there were 60-209 deaths per annum in which CDI was listed as a contributory factor in the death.
openaire   +2 more sources

The Rise and Fall and Rise Again of Toxin Testing for the Diagnosis of Clostridioides difficile Infection [PDF]

, 2019
Stuart Johnson
openalex   +1 more source