Clostridium difficile is a major cause of antibiotic-associated diarrhea and colitis. The incidence of infection with this organism is increasing in hospitals worldwide, consequent to the widespread use of broad-spectrum antibiotics. Pathogenic strains of C. difficile produce two protein exotoxins, toxin A and toxin B, that cause colonic mucosal injury
L, Kyne, R J, Farrell, C P, Kelly
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The synergistic necrohemorrhagic action of Clostridium perfringens perfringolysin and alpha toxin in the bovine intestine and against bovine endothelial cells [PDF]
Bovine necrohemorrhagic enteritis is a major cause of mortality in veal calves. Clostridium perfringens is considered as the causative agent, but there has been controversy on the toxins responsible for the disease.
Deprez, Piet+10 more
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Bezlotoxumab for prevention of recurrent Clostridium difficile infection in patients at increased risk for recurrence [PDF]
Background: Bezlotoxumab is a human monoclonal antibody against Clostridium difficile toxin B indicated to prevent C. difficile infection (CDI) recurrence (rCDI) in adults at high risk for rCDI. This post hoc analysis of pooled monocolonal antibodies for
Dorr, Mary Beth+12 more
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Bio-butanol production from bread waste with using the amylolytic Clostridium isolated from Parishan Lake [PDF]
Background and Aim: Bio-butanol has been regarded as an alternative to petroleum fuels due to its renewability. The aim of this study is to produce bio-butanol using bread waste and environmental bacteria.
Maryam Mirzadeh, Abbasali Rezaeian
doaj
Risk factors for recurrence in patients with Clostridium difficile infection due to 027 and non-027 ribotypes [PDF]
Objectives: Our objective was to evaluate factors associated with recurrence in patients with 027+ and 027– Clostridium difficile infection (CDI). Methods: Patients with CDI observed between January and December 2014 in six hospitals were consecutively ...
Aceti, A.+19 more
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REINVESTIGATION OF THE TAXONOMY OF CLOSTRIDIUM BIFERMENTANS AND CLOSTRIDIUM SORDELLII [PDF]
The taxonomic relationships between Clostridium bifermentans and C. sordellii were reinvestigated by numerical taxonomy, studies of DNA-DNA homology and DNA duplex thermal stability, and by analysis of cell-wall sugar components. Although the results indicate that both species may be grouped into one geno-species, C.
H. Hayashi+3 more
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Gut Dysbiosis and Neurobehavioral Alterations in Rats Exposed to Silver Nanoparticles [PDF]
Due to their antimicrobial properties, silver nanoparticles (AgNPs) are being used in non-edible and edible consumer products. It is not clear though if exposure to these chemicals can exert toxic effects on the host and gut microbiome. Conflicting studies have been reported on whether AgNPs result in gut dysbiosis and other changes within the host. We
arxiv +1 more source
Effects of Clostridium perfringens iota toxin in the small intestine of mice [PDF]
Iota toxin is a binary toxin solely produced by Clostridium perfringens type E strains, and is structurally related to CDT from C. difficile and CST from C. spiroforme.
Bruzzone, Octavio Augusto+8 more
core +1 more source
Exploitation of food feedstock and waste for production of biobutanol
Nine strains of solventogenic clostridia including the species C. acetobutylicum, C. beijerinckii, C. pasteurianum, and C. saccharoperbutylacetonicum were tested for the solvents production using potato, maize, and sugar beet molasses as substrates.
Petra Patáková+5 more
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Plasmids in Clostridium botulinum and related Clostridium species [PDF]
Toxigenic Clostridium botulinum and nontoxigenic C. sporogenes, C. subterminale, and C. botulinum-like organisms from a variety of sources were screened for plasmids. Of the 68 toxigenic C. botulinum isolates, 56% carried one or more plasmids, ranging in mass from 2.1 to 81 megadaltons. Within individual groups (based on the type of neurotoxin produced)
F T Poysky, M. W. Eklund, Mark S. Strom
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