Results 81 to 90 of about 253,202 (292)

Radiation‐Triggered Chemokine‐Secreting Probiotics for Boron Neutron Capture Therapy Based Radioimmunotherapy

Advanced Science, EarlyView.
Engineered Escherichia coli Nissle 1917 with a tannic acid‐mediated BPA coating enables tumor‐targeted boron delivery for BNCT. The low‐level incidental radiation generated during BNCT activate a RecA‐driven circuit to induce CXCL10, while radiation‐enhanced bacterial colonization triggers in situ vaccination and systemic antitumor immunity.
Yang Liu, Yuzhong Qian, Shaobo Huang, Bingbing Li, Yue Yu, Xiang Cheng, Chang Chen, Jiheng Wang, Maosong Yang, Lizheng Liang, Xiancai Meng, Zhigang Liu   +11 more
wiley   +1 more source

Structural and Functional Siderophore Remodeling by Enzymatic Delipidation

Angewandte Chemie, EarlyView.
A surprising functional switch in bacterial siderophores was discovered through genome mining and the analysis of environmental and pathogenic Pandoraea species. Pandorachelin B, a lipocyclopeptide that promotes swarming motility, is cleaved by a specialized acylase, yielding a ring‐contracted, homodetic cyclopeptide, pandorachelin A, which exhibits ...
Elena Herzog, Keishi Ishida, Evelyn M. Molloy, Ron Hermenau, Kirstin Scherlach, Christian Hertweck   +5 more
wiley   +2 more sources

Plain x-ray films in soft tissue infections

The Pan African Medical Journal, 2017
A 39-year-old male with a history of cocaine abuse presents to the emergency room with pain in the right leg and fever (39 C) 6 days after injecting himself in the thigh with midazolam pills diluted in tap water to control symptoms of withdrawal ...
Diogo Carrola Gomes, Luésa Quaresma
doaj   +1 more source

Comparison of the Hospital-Acquired Clostridium difficile Infection Risk of Using Proton Pump Inhibitors versus Histamine-2 Receptor Antagonists for Prophylaxis and Treatment of Stress Ulcers: A Systematic Review and Meta-Analysis

Gut and Liver, 2017
Background/AimsAlthough proton pump inhibitors (PPIs) have been widely used for the prevention and treatment of stress gastric ulcers in hospital settings, there are concerns that PPIs increase the risk of Clostridium difficile infection (CDI).
Mohamed Azab, Loomee Doo, Daniel H. Doo, Yousif Elmofti, Muazer Ahmed, John Jay Cadavona, Xibei B. Liu, Amaan Shafi, Moon Kyung Joo, Ji Won Yoo   +9 more
doaj   +1 more source

CLOSTRIDIUM BOTULINUM [PDF]

, 2022
Rod Clostridium čine sporogene, gram-pozitivne, anaerobne štapićaste bakterije. Pripadnici ovog roda imaju industrijski i medicinski značaj, obzirom da proizvode opasne toksine. Vrsta Clostridium botulinum široko je rasprostranjena, a proizvodi najotrovniji poznati toksin, botulinski neurotoksin, koji zbog jedinstvenih farmakoloških obilježja ima ...
openaire   +2 more sources

Molecular analysis of transferable tetracycline resistance plasmids from Clostridium perfringens [PDF]

, 1985
Conjugative tetracycline resistance plasmids from 15 Clostridium perfringens isolates from piggeries were analyzed by restriction endonuclease digestion and agarose gel electrophoresis. Seven isolates from one farm were found to carry a 47-kilobase pair (
Rood, J.I., Abraham, L.J.
core  

Clostridium perfringens epsilon toxin mutant Y30A-Y196A as a recombinant vaccine candidate against enterotoxemia [PDF]

, 2014
Epsilon toxin (Etx) is a β-pore-forming toxin produced by Clostridium perfringens toxinotypes B and D and plays a key role in the pathogenesis of enterotoxemia, a severe, often fatal disease of ruminants that causes significant economic losses to the ...
Bokori-Brown, M., Moss, David S., Titball, Richard W., Hall, C.A., Hall, CA, Fernandes da Costa, SP, Naylor, Claire, Cole, Ambrose R., Moss, DS, Naylor, Claire E., Fernandes da Costa, Sérgio P., Cole, AR, Hall, Charlotte, Basak, AK, Titball, R.W., Savva, CG, Hall, Charlotte A., Fernandes da Costa, S.P., Titball, Richard, Basak, Ajit K., Bokori-Brown, Monika, Vance, Charlotte, Vance, C, Vance, C., Naylor, CE, Savva, Christos G.   +25 more
core   +1 more source

Interleukin‐1α Mediates Pancreatic Fibroblast Activation, Regulates Immune Cell Recruitment and Fibrosis in Acute and Chronic Pancreatitis

Advanced Science, EarlyView.
During pancreatitis, IL‐1α is released from necrotic acinar cells. In response to IL‐1α, pancreatic fibroblasts release chemokines and cytokines that regulate the recruitment of immune cells to the damaged organ. Furthermore, IL‐1α primes fibroblasts, resulting in increased tissue fibrosis during chronic pancreatitis.
Hala Mazloum, Shenja Buchholz, Hanna Schifter, Sabine Ameling, Leif Steil, Ben Lewin Becker, Elke Hammer, Georg Homuth, Uwe Völker, Barbara M. Bröker, Lukas Zierke, Frank Ulrich Weiss, Juliane Glaubitz, Matthias Sendler   +13 more
wiley   +1 more source

A Conserved Isoleucine Gates the Diffusion of CO and O2 to the Active Site of NiFe CO‐Dehydrogenase

Angewandte Chemie, EarlyView.
A combination of protein film electrochemistry and site‐directed mutagenesis shows that isoleucine 563 (numbering of Thermococcus sp. AM4) gates the arrival of both CO and O2 to the active site of the nickel‐iron CO dehydrogenases. Mutations at this position increase the resistance to O2 at the cost of a slower reaction with CO.
Laura Opdam, Marta Meneghello, Chloé Guendon, Jade Chargelègue, Andrea Fasano, Aurore Jacq‐Bailly, Christophe Léger, Vincent Fourmond   +7 more
wiley   +2 more sources

Recent Developments of the Synthetic Biology Toolkit for Clostridium

Frontiers in Microbiology, 2018
The Clostridium genus is a large, diverse group consisting of Gram-positive, spore-forming, obligate anaerobic firmicutes. Among this group are historically notorious pathogens as well as several industrially relevant species with the ability to produce ...
Rochelle C. Joseph, Nancy M. Kim, Nicholas R. Sandoval   +2 more
doaj   +1 more source