Results 1 to 10 of about 74,841 (314)

Evolutionary Features in the Structure and Function of Bacterial Toxins

Toxins, 2019
Toxins can function both as a harmful and therapeutic molecule, depending on their concentrations. The diversity in their function allows us to ask some very pertinent questions related to their origin and roles: (a) What makes them such effective ...
Raj Kumar, Thomas M. Feltrup, Roshan V. Kukreja, Kruti B. Patel, Shuowei Cai, Bal Ram Singh   +5 more
doaj   +1 more source

Effect of treating elbow flexor spasticity with botulinum toxin injection and adjunctive casting on hemiparetic gait parameters: A prospective case series

Journal of Rehabilitation Medicine, 2020
Objective: To investigate changes in hemiparetic gait parameters after treatment of elbow flexor spasticity with botulinum neurotoxin (BoNT) injection and adjunctive casting. Design: Prospective case series.
Supun Kotteduwa Jayawarden, Ryan Sandarage, Jordan Farag, Carl Ganzert, Paul Winston, Patricia Mills, Rajiv Reebye   +6 more
doaj   +1 more source

Vitamin D (steroid hormone) and the nervous system diseases (literature review)

Сибирский научный медицинский журнал, 2020
The present review aims to summarize the activities of vitamin D effects on the nervous system and to clarify a vitamin D role in brain diseases, in the pathogenesis or as a serum biomarker for the disease development and severity. Objective: correlation
D. A. Novotnyy, N. G. Zhukova, L. Р. Shperling, V. A. Stolyarova, I. A. Zhukova, A. E. Agasheva, S. V. Shtaimets, O. A. Druzhinina   +7 more
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Rapid eye movement sleep behavior disorder: modern concept and Parkinson’s disease correlation [PDF]

Анналы клинической и экспериментальной неврологии
This review describes the association between rapid eye movement (REM) sleep behavior disorder (RBD) and synucleinopathies, primarily Parkinson's disease.
Diana M. Khasanova, Zuleykha A. Zalyalova, Guzal R. Ilina, Nailya I. Bagdanova   +3 more
doaj   +1 more source

Quality of life at cervical distonia

Бюллетень сибирской медицины, 2020
The aim of the study was to study the physical and psychological components regarding the quality of life of patients with cervical dystonia.Material and methods. 170 respondents were examined. The main group included 120 patients with cervical dystonia,
O. A. Druzhinina, N. G. Zhukova, L. P. Shperling   +2 more
doaj   +1 more source

Effect of vitamin D and other indicators of phosphorus-calcium metabolism on cognitive functions and quality of life in patients with Parkinson's disease

Неврология, нейропсихиатрия, психосоматика, 2022
Parkinson’s disease (PD) is a multifactorial neurodegenerative disease. Consequently, there has been growing interest in identifying early preclinical disease symptoms and searching for their laboratory markers in recent decades.Objective: to studythe ...
D. A. Novotnyy, N. G. Zhukova, L. P. Shperling, V. A. Stolyarova, I. A. Zhukova, A. E. Agasheva, S. V. Shtaimets, O. A. Druzhinina, I. V. Shirokikh   +8 more
doaj   +1 more source

Recombinant botulinum neurotoxin serotype A1 in vivo characterization

Pharmacology Research & Perspectives, 2021
Clinically used botulinum neurotoxins (BoNTs) are natural products of Clostridium botulinum. A novel, recombinant BoNT type A1 (rBoNT/A1; IPN10260) has been synthesized using the native amino acid sequence expressed in Escherichia coli and has previously
Cindy Périer, Vincent Martin, Sylvie Cornet, Christine Favre‐Guilmard, Marie‐Noelle Rocher, Julien Bindler, Stéphanie Wagner, Emile Andriambeloson, Brian B. Rudkin, Rudy Marty, Alban Vignaud, Matthew Beard, Stephane Lezmi, Mikhail Kalinichev   +13 more
doaj   +1 more source

Centaur antibodies: Engineered chimeric equine-human recombinant antibodies

Frontiers in Immunology, 2022
Hyper-immune antisera from large mammals, in particular horses, are routinely used for life-saving anti-intoxication intervention. While highly efficient, the use of these immunotherapeutics is complicated by possible recipient reactogenicity and limited
Ronit Rosenfeld, Ron Alcalay, Anat Zvi, Alon Ben-David, Tal Noy-Porat, Theodor Chitlaru, Eyal Epstein, Ofir Israeli, Shirley Lazar, Noa Caspi, Ada Barnea, Eyal Dor, Inbar Chomsky, Shani Pitel, Efi Makdasi, Ran Zichel, Ohad Mazor   +16 more
doaj   +1 more source

Passive Antibody Administration (Immediate Immunity) as a Specific Defense Against Biological Weapons

Emerging Infectious Diseases, 2002
The potential threat of biological warfare with a specific agent is proportional to the susceptibility of the population to that agent. Preventing disease after exposure to a biological agent is partially a function of the immunity of the exposed ...
Arturo Casadevall
doaj   +1 more source

Replacement of the Mouse LD₅₀ Assay for Determination of the Potency of AbobotulinumtoxinA with a Cell-Based Method in Both Powder and Liquid Formulations

Toxins, 2023
Botulinum neurotoxins (BoNTs) are important therapeutic agents. The in vivo median lethal dose (LD50) assay has been commonly used to measure the potency of BoNT commercial preparations.
Elena Fonfria, Elizabeth Marks, Lisa-Marie Foulkes, Rebecca Schofield, Daniel Higazi, Sam Coward, Alistair Kippen   +6 more
doaj   +1 more source