Results 21 to 30 of about 48,590 (264)
Emerging Infectious Diseases, 2002 The potential threat of biological warfare with a specific agent is proportional to the susceptibility of the population to that agent. Preventing disease after exposure to a biological agent is partially a function of the immunity of the exposed ...
Arturo Casadevall
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Toxins, 2023 Botulinum neurotoxins (BoNTs) are important therapeutic agents. The in vivo median lethal dose (LD50) assay has been commonly used to measure the potency of BoNT commercial preparations.
Elena Fonfria +6 more
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On Botulinum Neurotoxin Variability [PDF]
mBio, 2015 ABSTRACT The rapidly growing number of botulinum neurotoxin sequences poses the problem of the possible evolutionary significance of the variability of these superpotent neurotoxins for toxin-producing Clostridium species. To progress in the understanding of this remarkable phenomenon, we suggest that researchers should (i) abandon an anthropocentric ...
MONTECUCCO, CESARE +1 more
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Therapeutic Approach to Botulinum Injections for Hemifacial Spasm, Synkinesis and Blepharospasm
Toxins, 2022 The aim of this study was to show our therapeutic outcome of botulinum injection to the facial muscles and thereby to find the best therapeutic concept which should be embraced.
Gilad Yahalom +3 more
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The Use of Botulinum Toxin in Medicine: Safety and Efficacy Based on the Latest Research
Journal of Education, Health and Sport, 2023 Introduction and aim of the study: Botulinum toxin, produced by anaerobic bacteria of the Clostridium botulinum family, is one of the most potent organic compounds known to man. Despite its toxicity, it has found widespread use in medicine.
Anna Jaremek +8 more
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Major pathogenic Clostridia in human and progress toward the clostridial vaccines [PDF]
Iranian Journal of Basic Medical Sciences, 2022 The Clostridium genus is composed of a large spectrum of heterogeneous bacteria. They are Gram-positive, mostly mesophilic, and anaerobic spore-forming strains. Clostridia are widely distributed in oxygen-free habitats.
Lida Abdolmohammadi Khiav +1 more
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Menopause Review, 2023 This review looks at the use of botulinum toxin in the gynaecological field with the aim of determining what needs to be further investigated to achieve a standardized application.
Andrea Etrusco +5 more
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Biosecurity Threat Posed by Botulinum Toxin
Toxins, 2019 The deliberate release of biological agents with terrorist or criminal intent continues to pose concerns in the current geopolitical situation. Therefore, attention is still needed to ensure preparedness against the potential use of pathogens as ...
Orlando Cenciarelli +2 more
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Неврология, нейропсихиатрия, психосоматика, 2022 Parkinson’s disease (PD) is a multifactorial neurodegenerative disease. Consequently, there has been growing interest in identifying early preclinical disease symptoms and searching for their laboratory markers in recent decades.Objective: to studythe ...
D. A. Novotnyy +8 more
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Botulinum and Tetanus Neurotoxins
Annual Review of Biochemistry, 2019 Botulinum neurotoxins (BoNTs) and tetanus neurotoxin (TeNT) are the most potent toxins known and cause botulism and tetanus, respectively. BoNTs are also widely utilized as therapeutic toxins. They contain three functional domains responsible for receptor-binding, membrane translocation, and proteolytic cleavage of host proteins required for synaptic ...
Dong, Min +2 more
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