Development and validation of a targeted LC-MS/MS quantitation method to monitor cell culture expression of tetanus neurotoxin during vaccine production [PDF]
The tetanus neurotoxin (TeNT) is one of the most toxic proteins known to man, which prior to the use of the vaccine against the TeNT producing bacteria Clostridium tetani, resulted in a 20 % mortality rate upon infection. The clinical detrimental effects of tetanus have decreased immensely since the introduction of global vaccination programs, which ...
arxiv +1 more source
Diarrhoea caused by Clostridium difficile in patients with postoperative subhepatic abscess [PDF]
Background. Toxigenic strains of Clostridium difficile in the majority of cases cause disease of the intestinal tract of hospitalized patients. For a long time, Clostridium difficile was considered to produce both types of toxins (A+/B+ strain), however,
Stojanović Predrag, Kocić Branislava
doaj +1 more source
Introduction Clostridioides difficile infection (CDI) is a recognized global threat especially for vulnerable populations. It is of particular concern to healthcare providers as it is found in both hospital and community settings, with severe courses ...
Gordon Brestrich+15 more
doaj +1 more source
Clinical Utility and Alterations in Bacterial Flora in Fecal Microbiome Transplantation
Dysbiotic states of gut ecology can be altered directly by transplantation of fecal preparation from healthy donors to patients with therapeutic intent.
Atman A. Dave, Rachel Robson
doaj +1 more source
Clostridium difficile infection
Clostridium difficile infection (CDI) is a significant and increasing medical problem, surpassing methicillin-resistant Staphylococcus aureus as the most common hospital-onset or facility-associated infection, and a key element in the challenging battle against hospital-acquired infections.
Fernando Peixoto Ferraz de Campos+1 more
openaire +4 more sources
Gram-positive Rod Surveillance for Early Anthrax Detection
Connecticut established telephone-based gram-positive rod (GPR) reporting primarily to detect inhalational anthrax cases more quickly. From March to December 2003, annualized incidence of blood isolates was 21.3/100,000 persons; reports included 293 ...
Elizabeth M. Begier+4 more
doaj +1 more source
Health outcomes of statin users compared to non-users with Clostridium difficile infection [PDF]
Background: Clostridium difficile infection (CDI) is the most common cause of nosocomial diarrhea, and the primary cause of healthcare-associated infections in the United States. Statins have beneficial effects independent of their lipid-lowering effects;
Argamany, Jacqueline Rose
core +1 more source
Rethinking the role of alpha toxin in Clostridium perfringens-associated enteric diseases : a review on bovine necro-haemorrhagic enteritis [PDF]
Bovine necro-haemorrhagic enteritis is an economically important disease caused by Clostridium perfringens type A strains. The disease mainly affects calves under intensive rearing conditions and is characterized by sudden death associated with small ...
Deprez, Piet+6 more
core +3 more sources
Clostridium difficile infection: review [PDF]
Clostridium difficile (C. difficile) is a Gram-positive, spore-forming, anaerobic bacillus, which is widely distributed in the intestinal tract of humans and animals and in the environment. In the last decade, the frequency and severity of C. difficile infection has been increasing worldwide to become one of the most common hospital-acquired infections.
Jacek Czepiel+9 more
openaire +5 more sources
Laboratory data as a quality indicator of health-care-associated infections in England. [PDF]
Routine diagnostic laboratory results, e.g. numbers of meticillin-resistant Staphylococcus aureus (MRSA) bacteraemias, have been used as health-care-associated infection quality indicators for decades. The English health-care-associated infection quality
Jeyaratnam, D, Planche, T
core +1 more source