Results 41 to 50 of about 165,772 (340)

Lactylated SPTAN1 Accelerates Hepatocellular Carcinoma Progression by Promoting NOTCH1/HES1 Activation and Immunosuppression

Advanced Science, EarlyView.
This study identifies SPTAN1‐kla as a novel oncogenic driver in HBV‐driven HCC, linking metabolic, epigenetic, and immune mechanisms. SPTAN1‐kla promotes HCC progression via NOTCH1/HES1 activation and immunosuppression. Findings highlight that targeting SPTAN1‐kla provides a framework for HCC treatment to improve clinical outcomes in HBV infected ...
Zengbin Wang, Dongjie Ye, Linqing Wu, Jiayu Liu, Banglun Pan, Zhu Zhang, Xiaoxia Zhang, Yuxin Yao, Nanhong Tang   +8 more
wiley   +1 more source

Association of tcdB PCR Cycle Threshold with Toxin Antigen Positivity and Clinical Severity in Clostridioides difficile Infection

Korean Journal of Clinical Laboratory Science
Various methods are used to diagnose and evaluate the severity of a Clostridioides difficile infection (CDI). Among them, the correlation between the tcdB gene PCR cycle threshold (Ct) values and toxin antigen detection is a key area of research.
Chan Kyu KIM, Ho-Keun CHOI
doaj   +1 more source

CLOSTRIDIUM DIFFICILE ASSOCIATED DISEASE IN THE NEUROINTENSIVECARE UNIT.

Frontiers in Neurology, 2013
. BACKGROUND- Critically ill patients are at high risk for acquiring Clostridium difficile infection. The aim of this study was to investigate the prevalence, severity and outcome of Neurointensive Care Unit (NICU) acquired Clostridium difficile ...
Swagata eTripathy, Priya eNair, Michael eRothburn, Michael eRothburn   +3 more
doaj   +1 more source

Gut Bacteria Improve Depressive Symptoms by Degrading Cortisol into Androgen

Advanced Science, EarlyView.
Chronic stress is an important risk factor for stress‐related disorders such as depression. Stress hormone cortisol is essential for the pathogenesis of stress‐related disorders such as depression. Some gut microbiota degraded cortisol, and improve depressive symptoms.
Xiong Wang, Qing Wu, Hao‐Long Zeng, Yin Shen, Hong‐Han Zhang, Jun Gong, Qi Zhang, Jia‐Zhao Xie, Da‐Wei Ye, Zi‐Yong Sun, Zhong‐Chun Liu, Li‐Ming Cheng, Di Li   +12 more
wiley   +1 more source

Lifting the lid: a clinical audit on commode cleaning [PDF]

, 2010
Many healthcare-associated infections (HCAIs) are preventable by infection control procedures designed to interrupt the transmission of organisms from a source. Commodes are in use constantly throughout healthcare facilities.
Ayliffe GAJ, Biotrace., Centres for Disease Control and Prevention, Cresswell J., Department of Health, Department of Health, Department of Health, Department of Health, Helen Bucior, Higgs J., I nfection Control Nurses Association, Inglis TJJ., Joan Cochrane, LoBiondo-Wood G., National Audit Office, National Clostridium difficile Standards Group, National Institute for Clinical Excellence, National Patient Safety Agency, NHS Estates, Pratt R., Wilson J.   +20 more
core   +2 more sources

Application of MALDI-TOF MS to assess clinical characteristics, risk factors, and outcomes associated with anaerobic bloodstream infection: a retrospective observational study

Annals of Clinical Microbiology and Antimicrobials, 2021
Background Correctly identifying anaerobic bloodstream infections (BSIs) is difficult. However, a new technique, matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS), enables more accurate identification and ...
Tsuyoshi Watanabe, Yuki Hara, Yusuke Yoshimi, Waka Yokoyama-kokuryo, Yoshiro Fujita, Masamichi Yokoe, Yoshinori Noguchi   +6 more
doaj   +1 more source

Principles for Rigorous Design and Application of Synthetic Microbial Communities

Advanced Science, EarlyView.
SynComs are artificially designed to enable inter‐species metabolic interactions, metabolic division of labor, and ecological interactions that can elicit phenotypes like colonization stability and environmental adaptation. This systematic review explores the processes used to construct SynComs, the assessment of the mechanisms of metabolic interaction
Yuxiao Zhang, Minyu Jing, Lihui Lyu, Li Nie, Xihui Xu, Ru Sun, Xiyuan Xu, Siyu Chen, Shuobing He, Yumeng Zhang, Ping Huang, Weijie Luo, Jiaojiao Liang, Guifeng Gao, Kunkun Fan, Teng Yang, Liyan Zhang, Xiao Fu, Sarah M. Allard, Jack A. Gilbert, Jiabao Zhang, Haiyan Chu   +21 more
wiley   +1 more source

Effects of co-infection on the clinical outcomes of Clostridium difficile infection [PDF]

, 2020
Background: Clostridium difficile (C. difficile) is a spore-forming, Gram-positive rod that is known to be associated with antibiotic use. It is one of the leading causes of nosocomial diarrhea in the industrialized world and therefore warrants further ...
Alturkmani, Hani, Brewer, Joseph, Lodhi, Hafsa, Mittal, Vishal, Shafiq, Muhammad, Ullah, Waqas, Zafar, Yousaf   +6 more
core   +1 more source

Clostridium difficile colitis in patients after kidney and pancreas-kidney transplantation [PDF]

, 2004
Limited data exist about Clostridium difficile colitis (CDC) in solid organ transplant patients. Between 1/1/99 and 12/31/02, 600 kidney and 102 pancreas–kidney allograft recipients were transplanted.
Basu, A, Fung, JJ, Keven, K, Marcos, A, Re, L, Shapiro, R, Simmons, RL, Starzl, TE, Tan, H   +8 more
core   +1 more source

Exploring the potential of cold plasma therapy in treating bacterial infections in veterinary medicine: opportunities and challenges

Frontiers in Veterinary Science, 2023
Cold plasma therapy is a novel approach that has shown significant promise in treating bacterial infections in veterinary medicine. Cold plasma possesses the potential to eliminate various bacteria, including those that are resistant to antibiotics ...
Parvin Mohseni, Abozar Ghorbani, Niloofar Fariborzi   +2 more
doaj   +1 more source