Results 1 to 10 of about 76,424 (294)

A Japanese Pregnant Woman With Treatment‐Resistant Schizophrenia Who Continued Clozapine With Blood Concentration Monitoring During the Perinatal Period and Had a Healthy Baby: A Case Report [PDF]

Neuropsychopharmacology Reports
Background Clozapine is known to improve the social functioning of patients with treatment‐resistant schizophrenia (TRS). In Japan, there are few reports on pregnancy and childbirth in patients treated with clozapine, and information on its effects on ...
Mariko Tsukiji, Kaori Yamazaki, Yusuke Nakata, Tsuyoshi Sasaki, Keita Idemoto, Kazuki Okada, Shingo Yamazaki, Akiko Omoto, Kaori Koga, Tomihisa Niitsu, Itsuko Ishii   +10 more
doaj   +2 more sources

Saliva Based Clozapine Therapeutic Drug Monitoring: A Systematic Review [PDF]

Pharmacology Research & Perspectives
Clozapine is superior in the treatment of treatment‐refractory schizophrenia but requires therapeutic drug monitoring (TDM) due to its unpredictable pharmacokinetics and dose‐dependent side effects.
Tessa Rademaker, Rachel Chu, Suhaila Hasan, Anthony Harris, Jan‐Willem Alffenaar   +4 more
doaj   +2 more sources

Rapid On-Demand Point-of-Care Monitoring of Clozapine and Its Metabolite Norclozapine Using Miniature Mass Spectrometry. [PDF]

Pharmaceuticals (Basel)
Wang X, Lew WY, Yang Y, Zhang N, Bu J, Li Z, Fitzpatrick M, Bonnitcha P, Sullivan D, Zhang W, Zheng Y, O'Sullivan JF.   +11 more
europepmc   +3 more sources

Underuse of recommended treatments among people living with treatment-resistant psychosis

Frontiers in Psychiatry, 2022
BackgroundInternational guidelines recommend that individuals with treatment-resistant psychosis must be treated with clozapine. ECT has also been reported to improve symptom profiles.
Julia M. Lappin, Julia M. Lappin, Kimberley Davies, Kimberley Davies, Maryanne O'Donnell, Maryanne O'Donnell, Ishan C. Walpola, Ishan C. Walpola   +7 more
doaj   +1 more source

Point-of-care haematological monitoring during treatment with clozapine

Journal of Laboratory Medicine, 2022
Patients treated with clozapine are required to have regular venous blood samples taken to measure white blood cell (WBC) and neutrophil counts to reduce the risk of agranulocytosis.
Atkins Matthew, McGuire Philip, Balgobin Bhirundra, Williams Sophie, Ceesay Fatou, Desouza Neville, Patel Pravinkumar, Taylor David   +7 more
doaj   +1 more source

Elevated clozapine levels in patients with COVID-19 infection

European Psychiatry, 2021
Introduction Clozapine is the most effective antipsychotic for treatment resistant schizophrenia. In patients treated with clozapine, COVID-19 infection may result in complications including an increased risk of pneumonia, clozapine toxicity, and ...
J. Marti Bonany, E. Pérez Sánchez, M. Pérez Carre, M.I. Martínez Casamitjana, J.R. Fortuny Olive, C. Macias Castellví, E. Carrió Diez, F. Lana Moliner, R. Sánchez González   +8 more
doaj   +1 more source

Clozapine prescription rates in Southeast Europe: A cross-sectional study

Frontiers in Psychiatry, 2023
IntroductionInternational reports indicate that clozapine is under prescribed. Yet, this has not been explored in Southeast European (SEE) countries. This cross-sectional study investigates clozapine prescription rates in a sample of 401 outpatients with
Manuela Russo, Manuela Russo, Dragana Ignjatovic-Ristic, Dan Cohen, Aliriza Arenliu, Stojan Bajraktarov, Alma Dzubur Kulenovic, Lidija Injac Stevovic, Nadja Maric, Antoni Novotni, Nikolina Jovanovic   +10 more
doaj   +1 more source

Clozapine-associated neutropenia following augmentation with sodium valproate

SAGE Open Medical Case Reports, 2021
Clozapine is gold standard for the management of treatment-resistant schizophrenia. It can offer life-changing symptom reduction where other antipsychotics have failed, and for these patients, treatment with clozapine should be maintained, if in any ...
Michelle Iris Jakobsen, H Grønborg, H V Hansen, A Fink-Jensen   +3 more
doaj   +1 more source

Clozapine is strongly associated with the risk of pneumonia and inflammation

General Psychiatry, 2020
Clinicians need to remember that (1) systemic inflammations can increase clozapine level; (2) clozapine, by itself, can cause inflammation, particularly during titration that is too rapid for that patient; (3) clozapine may increase the risk of infection;
Chuanyue Wang, Jose de Leon, Can-Jun Ruan, Hélène Verdoux   +3 more
doaj   +1 more source

Use of olanzapine compared with clozapine for treatment-resistant schizophrenia in a real-world setting: nationwide register-based study

BJPsych Open, 2021
Background Clozapine is generally considered as the treatment of choice for patients with treatment-resistant schizophrenia (TRS). However, its superiority has recently been questioned because olanzapine has been suggested as non-inferior to clozapine ...
Young Tak Jo, Sung Woo Joo, Soojin Ahn, Youngjae Choi, Jungsun Lee   +4 more
doaj   +1 more source