Results 91 to 100 of about 29,714 (222)

What drives prolonged hospital stays in schizophrenia‐spectrum disorders? A Canadian tertiary care review

Psychiatry and Clinical Neurosciences Reports, Volume 5, Issue 3, September 2026.
Abstract Aim Schizophrenia imposes significant economic and social burdens, often resulting in prolonged inpatient length of stay (LOS), particularly for treatment‐resistant cases. This study aimed to identify clinical, demographic, and social factors associated with prolonged LOS in a Canadian tertiary schizophrenia inpatient unit to highlight ...
Naista Zhand, Ali Manghi, Fatima Iftikhar, Yiling Zhu, Rebecca Sunderland, Carrie Robertson   +5 more
wiley   +1 more source

Saliva Based Clozapine Therapeutic Drug Monitoring: A Systematic Review

Pharmacology Research & Perspectives
Clozapine is superior in the treatment of treatment‐refractory schizophrenia but requires therapeutic drug monitoring (TDM) due to its unpredictable pharmacokinetics and dose‐dependent side effects.
Tessa Rademaker, Rachel Chu, Suhaila Hasan, Anthony Harris, Jan‐Willem Alffenaar   +4 more
doaj   +1 more source

Heartfelt intervention: A role for PVN oxytocin neurons in the prediabetic heart

The Journal of Physiology, EarlyView.
Grace K. Nielsen, Reesa M. Wilcox, Han‐Jun Wang   +2 more
wiley   +1 more source

Nocturnal awakening secondary to pain in sleep‐related painful erection: A case report and literature review

Sleep Research, Volume 3, Issue 3, Page 286-291, September 2026.
Abstract A 41‐year‐old male patient presented with a 13‐year history of recurrent nocturnal penile pain associated with erections during sleep. Over the course of his illness, the patient attended outpatient clinics on 298 occasions and was hospitalized three times. The primary symptom reported was erectile pain occurring during sleep.
Liping Zhang, Jinxiang Cheng, Jiaxiu He, Rui Guo, Changjun Su, Xianchao Zhao   +5 more
wiley   +1 more source

Understanding excessive sleep in people with psychotic disorders

British Journal of Clinical Psychology, Volume 65, Issue 3, Page 762-776, September 2026.
Abstract Background There has been increasing attention to sleep disturbances such as insomnia in psychosis, due to its impact on symptoms, well‐being, and recovery. However, excessive sleep and extended sleep duration are common in psychosis (partly linked to sedating antipsychotic medication) and have been relatively neglected, despite plausible ...
Kate Robbins, Joanne Hodgekins, Sarah Reeve   +2 more
wiley   +1 more source

Psychotropic medication use among community dwellers with and without Parkinson's disease – A nationwide cohort study

British Journal of Clinical Pharmacology, Volume 92, Issue 8, Page 2701-2710, August 2026.
Abstract Aims We studied the prevalence of psychotropic use and psychotropic polypharmacy in persons with Parkinson's disease (PD) during a 10‐year follow‐up, because longitudinal studies on this topic are scarce although non‐motor symptoms of PD are often treated with psychotropics.
Noora Nieminen, Anna‐Maija Tolppanen, Valtteri Kaasinen, Marjaana Koponen, Sirpa Hartikainen   +4 more
wiley   +1 more source

Endogenous melatonin partial metabolic clearance as a potential endogenous marker of CYP1A2 activity

British Journal of Clinical Pharmacology, Volume 92, Issue 8, Page 2899-2908, August 2026.
Aims Cytochrome P450 1A2 (CYP1A2) exhibits substantial interindividual variability, necessitating appropriate phenotyping strategies for personalized pharmacotherapy. This study evaluated endogenous melatonin partial metabolic clearance (CLm(MEL)), calculated from urinary 6‐hydroxymelatonin (6‐O‐MEL) excretion and plasma melatonin (MEL) exposure, as a ...
Akitomo Yokokawa, Hayato Shimazaki, Shunji Igarashi, Yoshiki Tagawa, Naoki Hisada, Hiromi Shibasaki   +5 more
wiley   +1 more source

An Olfactory Piriform Cortex‐Lateral Hypothalamus Neural Circuit Contributes to Linalool‐Induced Analgesia

CNS Neuroscience &Therapeutics, Volume 32, Issue 8, August 2026.
Linalool odor exposure activates a glutamatergic projection from the piriform cortex to the lateral hypothalamus (PiriGlu‐LH), mediating descending inhibitory pain pathways. This demonstrates a novel neural mechanism for olfactory‐induced pain modulation and suggests potential therapeutic implications for pain management.
Yunhe Zhu, Jingping Sun, Shan Wang, Qidong Zhang, Jian Mao, Guobi Chai, Qingzhao Shi, Wu Fan, Jianping Xie   +8 more
wiley   +1 more source

A psychiatric medication, clozapine, induces autophagy and apoptosis in breast cancer cells through reactive oxygen species.

PLoS ONE
Cancer patients with psychotic disorders have occasionally exhibited reduced tumor sizes following long-term antipsychotic treatment. Previous studies have shown that antipsychotic drugs, such as clozapine, could inhibit cancer cell proliferation, but ...
Ya-Chun Fan, Shih-Chao Lin, Po-Jung Lai, Pei-Chun Lai, Germain Maurus, Shiow-Yi Chen   +5 more
doaj   +1 more source

PharmVar GeneFocus: CYP1A2—Clinical Impact, Genetic Variation, and Updated Nomenclature

Clinical Pharmacology &Therapeutics, Volume 120, Issue 2, Page 313-323, August 2026.
The Pharmacogene Variation Consortium (PharmVar) provides nomenclature for the highly polymorphic human CYP1A2 gene. CYP1A2 plays a crucial role in the biotransformation of several commonly used drugs, including antipsychotics, antidepressants, anxiolytics, and methylxanthines.
Katalin Monostory, Gonzalo Villapalos Garcia, Dora Koller, Solomon Adams, Chad A. Bousman, Evangelia Eirini Tsermpini, Michelle Whirl‐Carrillo, Amy J. Turner, Volker M. Lauschke, Mohamed Nagy, Erin C. Boone, Teri E. Klein, Pablo Zubiaur, Andrea Gaedigk   +13 more
wiley   +1 more source