Results 91 to 100 of about 45,210 (266)

Clozapine in the community [PDF]

British Journal of Psychiatry, 1992
M, Phelan, G, Strathdee, K, Jones
openaire   +2 more sources

Energetic dysregulations in psychotic disorders: Targets for new therapeutics

The FEBS Journal, EarlyView.
The present review synthesizes literature documenting aberrant energy production and use, specifically related to mitochondrial and redox dysregulation, in psychotic disorders. Findings from different levels of investigation—genetic, cellular, and in vivo imaging—converge on aberrant energy metabolism as a hallmark of psychotic disorders.
Jacey Anderson, Kai‐Christian Sonntag, Thao Do Vy Le, Kaitlin Shannon, Chao Wang, Fei Du, Xi Chen, Donna McPhie, Dost Ongur, Bruce Cohen, Virginie‐Anne Chouinard   +10 more
wiley   +1 more source

Blood Cell Counts and the Duffy Null Phenotype: Beyond Neutropenia

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT The absence of Duffy antigen expression on red blood cells, caused by a single nucleotide polymorphism in the DARC/ACKR1 gene, confers protection against malaria and is associated with lower absolute neutrophil counts (ANC) in some studied populations.
Elvira Deolinda R. P. Velloso, Andreza Oliveira dos Santos, Carla Luana Dinardo, Carolina Bonet Bub, Leandro Dinalli Santos, Mauren Fernanda Moller dos Santos, João Carlos de Campos Guerra, Denise dos Anjos Laurentis de Sousa Campos, Monica Juliana Vieira, Fábio Julio da Luz, Alfredo Mendrone‐Junior, Rosana M. Cosentino Penteado   +11 more
wiley   +1 more source

Annual Research Review: Psychosis in children and adolescents: key updates from the past 2 decades on psychotic disorders, psychotic experiences, and psychosis risk

Journal of Child Psychology and Psychiatry, Volume 66, Issue 4, Page 460-476, April 2025.
Psychosis in children and adolescents has been studied on a spectrum from (common) psychotic experiences to (rare) early‐onset schizophrenia spectrum disorders. This research review looks at the state‐of‐the‐art for research across the psychosis spectrum, from evidence on psychotic experiences in community and clinical samples of children and ...
Ian Kelleher
wiley   +1 more source

Clozapine-Associated Agranulocytosis Treatment With Granulocyte Colony-Stimulating Factor/Granulocyte-Macrophage Colony-Stimulating Factor: A Systematic Review.

, 2017
PURPOSE/BACKGROUND: Clozapine is associated with hematological abnormalities, notably neutropenia, which may progress to agranulocytosis. Granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) have ...
John Lally (7896821), Steffi Malik (7955525), James H. MacCabe (7955552), Eromona Whiskey (7955540), Amir Krivoy (6667283), Robert J. Flanagan (7955546), David M. Taylor (4342150), Fiona P. Gaughran (7955543), Aleksandar Mijovic (7955549)   +8 more
core   +1 more source

Clozapine in primary care [PDF]

, 2017
Clozapine is the most effective antipsychotic, but is reserved for people with schizophrenia who have not adequately responded to two other antipsychotics. It has a high adverse event burden and requires close monitoring.
Winckel, Karl, Karl Winckel, Siskind, Dan, Dan Siskind   +3 more
core   +1 more source

Annual Research Review: Psychosis in children and adolescents – a call to action: a commentary on Kelleher (2025)

Journal of Child Psychology and Psychiatry, Volume 66, Issue 4, Page 588-591, April 2025.
The spectrum of psychosis is highly relevant to child and adolescent mental health. Psychotic symptoms are common in children and adolescents. The onset of psychotic disorders is often preceded by neurodevelopmental problems in early childhood, and some 13% of adolescents attending specialist mental health services will later be diagnosed with a ...
James G. Scott
wiley   +1 more source

Clozapine-induced pneumonitis mimicking an atypical pneumonia

Clozapine is an antipsychotic used for treatment-resistant schizophrenia with a significant side effect profile, including agranulocytosis, myocarditis and fever.
Jasenthu Kankanamage, Nuwan, Vaselli, Natasha Marcella, Du Preez, Stanley   +2 more
core   +1 more source

An Electronic Health Record “Nudge” to Reduce Antipsychotic Medication Prescribing for Primary Care Patients With Dementia: A Pragmatic RCT

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT Background We hypothesized that an electronic health record (EHR) alert grounded in behavioral science could reduce new antipsychotic medication prescriptions for older adults with dementia. Methods We conducted a pragmatic clinical trial at a large academic health system, randomizing providers to receive the alert (intervention) or not ...
Catherine A. Sarkisian, Chad Wes Villaflores, Anne M. Walling, Sitaram S. Vangala, Eric M. Cheng, Suzanne Bliven Shu, Ajaya Pillai, Grace Y. Cheng, Noah Goldstein, John Mafi   +9 more
wiley   +1 more source

What is the current scope of research assessing patients’ and clinicians’ perspectives on clozapine treatment? A comprehensive scoping review

BMJ Open
Objectives Clozapine is continuously underused. The existing systematic reviews addressing barriers to clozapine prescribing primarily focus on clinical staff’s attitudes and perceived barriers to prescribing.
Jimmi Nielsen, Erik Simonsen, Ole Jakob Storebø, Michelle Iris Jakobsen, Stephen F Austin, Julie Perrine Schaug   +5 more
doaj   +1 more source