Results 111 to 120 of about 62,277 (245)

Parasomnias and sleep‐related movement disorders induced by drugs in the adult population: a review about iatrogenic medication effects

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Parasomnias and sleep‐related movement disorders (SRMD) are major causes of sleep disorders and may be drug induced. The objective of this study was to conduct a systematic review of the literature to examine the association between drug use and the occurrence of parasomnias and SRMD.
Sylvain Dumont, Vanessa Bloch, Agnès Lillo‐Lelouet, Christine Le Beller, Pierre A. Geoffroy, Marc Veyrier   +5 more
wiley   +1 more source

Prediabetic cardiomyopathy is attenuated by hypothalamic PVN oxytocin neuron activation

The Journal of Physiology, EarlyView.
Abstract figure legend A long‐term high‐fat, high‐fructose diet induces prediabetes with insulin resistance, hyperinsulinaemia, elevated triglycerides and metabolic‐associated steatotic liver disease (MASLD) in male rats. Animals developed prediabetic cardiomyopathy characterized by diastolic dysfunction, interstitial fibrosis and tachycardia ...
Anna Nilsson, Joan Escobar, Kira Kuraoka, Ian Venter, Cielo A. Carnate, Matthew W. Kay, David Mendelowitz, Kathryn J. Schunke   +7 more
wiley   +1 more source

Electromechanical modelling and simulation of human‐induced pluripotent stem cell‐derived cardiomyocytes predict drug‐induced contractility effects

The Journal of Physiology, EarlyView.
Abstract figure legend A study described in this paper describes a new tool for hiPSC‐CM electromechanical behaviour simulations using mathematical modelling. The model enables in silico assays making drug testing quick, comprehensive and accurate. New hiPSC‐CM models can be used as a platform to integrate in vitro and in silico findings.
Milda Folkmanaite, Xin Zhou, Andreas Koschinski, Wan‐Hua Hong, Marilù Casini, Manuel Koch, Ursula Ravens, Remi Peyronnet, Manuela Zaccolo, Blanca Rodriguez   +9 more
wiley   +1 more source

COVID-19 disease outcomes in patients receiving clozapine versus other antipsychotics: a national study in Qatar

Frontiers in Psychiatry
BackgroundClozapine has immunomodulatory effects that raised concerns about its potential to exacerbate severe COVID-19. This study examines whether clozapine use is associated with worse COVID-19 outcomes in patients with schizophrenia.MethodsThis ...
Dalia Albahari, Oraib Abdalla, Shatha Mahmud Ismail Alqam, Mohammed Faisal Hamad Mohammed, Mohamed Ali Siddig Ahmed, Ovais Wadoo, Ovais Wadoo   +6 more
doaj   +1 more source

Anatomical and functional mapping of vagal nociceptive sensory nerve subsets innervating the mouse lower airways by intersectional genetics

The Journal of Physiology, EarlyView.
Abstract figure legend We used an intersectional approach with recombinase‐expressing mice and adeno‐associated virus to map and modulate distinct nociceptive afferents in the vagal ganglia. TRPV1+P2X2+ neurons resided in the nodose ganglion (N), innervated the lungs (many projected into the alveoli) but not the trachea, and projected to the nucleus ...
Mayur J. Patil, Justin Shane Hooper, Seol‐Hee Kim, Parmvir K. Bahia, Nika Pavelkova, Sanjay S. Nair, Teresa S. Darcey, Karina V. Lurye, Meghana Madaram, Jailene Fiallo, Stephen H. Hadley, Thomas E. Taylor‐Clark   +11 more
wiley   +1 more source

Case report: Time response of plasma clozapine concentrations on cessation of heavy smoking

Frontiers in Pharmacology
Smoking cessation in patients treated with clozapine might lead to elevated plasma concentrations and severe side effects. This case report investigated the trajectory of clozapine plasma concentrations over time after smoking cessation in a Chinese ...
Lingyan Qi, Botao Ma, Hongzhen Fan, Siyuan Qi, Fude Yang, Huimei An   +5 more
doaj   +1 more source

Metabool syndroom bij de behandeling met clozapine [PDF]

, 2009
Metabolic syndrome during clozapine treatment Objective: To assess the prevalence of metabolic syndrome in inpatients with psychotic disorders treated with clozapine for at least one year.
Heijden, F.M.M.A. (Frank) van der, Kok, J.D.H., Soest, M. van, Steylen, P.M.J. (Pauline), Tuinier, S. (Siegfried), Verhoeven, W.M.A. (Wim)   +5 more
core   +1 more source

Beat‐to‐beat variability of ventricular repolarization reveals sex‐specific instability and proarrhythmic risk

The Journal of Physiology, EarlyView.
Abstract figure legend A mechanistic framework linking sex‐dependent dynamical instability to proarrhythmic risk. Sex‐specific human ventricular models show that upstream modulators, including biological sex, hormones, drugs and heart disease, promote steeper APD restitution in female than male and enhance dynamical instability.
Daisuke Sato, Lorenzo Santini, Raffaele Coppini, Eleonora Grandi   +3 more
wiley   +1 more source

Pilot Study of Behavioral Activation Treatment for Negative Symptoms in Older Adults With Schizophrenia Spectrum Disorder

Psychiatric Research and Clinical Practice, EarlyView.
Objective Behavioral activation (BA) is an established treatment for depression in older adults, yet BA has been relatively less examined as a treatment for the negative symptoms (NS) of schizophrenia spectrum disorder (SSD). We here aimed to demonstrate the feasibility and proof‐of‐concept that BA can improve NS and function in older adults with SSD ...
Stephen F. Smagula, Jessica M. Gannon, Fabio Ferrarelli   +2 more
wiley   +1 more source

A Japanese Pregnant Woman With Treatment‐Resistant Schizophrenia Who Continued Clozapine With Blood Concentration Monitoring During the Perinatal Period and Had a Healthy Baby: A Case Report

Neuropsychopharmacology Reports
Background Clozapine is known to improve the social functioning of patients with treatment‐resistant schizophrenia (TRS). In Japan, there are few reports on pregnancy and childbirth in patients treated with clozapine, and information on its effects on ...
Mariko Tsukiji, Kaori Yamazaki, Yusuke Nakata, Tsuyoshi Sasaki, Keita Idemoto, Kazuki Okada, Shingo Yamazaki, Akiko Omoto, Kaori Koga, Tomihisa Niitsu, Itsuko Ishii   +10 more
doaj   +1 more source