Results 111 to 120 of about 45,210 (266)

Electrophysiological properties of the dorsal motor nucleus of the vagus motoneurones controlling airway mucus secretion in rats

The Journal of Physiology, EarlyView.
Abstract figure legend Acidosis depolarises parasympathetic respiratory motoneurones in the dorsal motor nucleus of the vagus (DMV) and increases their firing frequency by reducing TWIK‐2 channel conductance. Acidosis also activates astrocytes, which further enhance neuronal excitability through NMDA receptor‐dependent glutamatergic signalling.
Daniel P. de Souza, Renato W. Martins Sá, Luiza Henrique de Souza, Fernando S. Ramalho, Davi J. A. Moraes   +4 more
wiley   +1 more source

A Japanese Pregnant Woman With Treatment‐Resistant Schizophrenia Who Continued Clozapine With Blood Concentration Monitoring During the Perinatal Period and Had a Healthy Baby: A Case Report

Neuropsychopharmacology Reports
Background Clozapine is known to improve the social functioning of patients with treatment‐resistant schizophrenia (TRS). In Japan, there are few reports on pregnancy and childbirth in patients treated with clozapine, and information on its effects on ...
Mariko Tsukiji, Kaori Yamazaki, Yusuke Nakata, Tsuyoshi Sasaki, Keita Idemoto, Kazuki Okada, Shingo Yamazaki, Akiko Omoto, Kaori Koga, Tomihisa Niitsu, Itsuko Ishii   +10 more
doaj   +1 more source

Clozapine and Pneumonia: Synthesizing the Link by Reviewing Existing Reports—A Systematic Review and Meta-Analysis

Medicina
Background and Objectives: Clozapine is a highly effective antipsychotic used for treating treatment-refractory psychotic and mood disorders. However, clozapine also has a serious risk of side effects leading to mortality, particularly its potentiated ...
Victor Zhao, Yiting Gong, Naveen Thomas, Soumitra Das   +3 more
doaj   +1 more source

Artesunate prevents rats from the clozapine-induced hepatic steatosis and elevation in plasma triglycerides

, 2017
Yanmei Li,1,2 Ruibing Su,3 Shuqin Xu,2 Qingjun Huang,1 Haiyun Xu1,2 1The Mental Health Center, Shantou University Medical College, Shantou, Guangdong Province, People’s Republic of China; 2Department of Anatomy, Shantou University Medical College,
Li Y, Su R, Xu S, Huang Q, Xu H
core  

The Effect of Clozapine on Tremor in Patients with Parkinson’s Disease who were Initiated Clozapine For Psychotic Symptoms

, 2013
Aim: Tremor is one of the initial symptoms of Parkinson’s disease and most of the patients suffer from it along the course of the disease. Levodopa and dopamine agonists are used as first-line therapy.
Aytül Mutlu, Hasan Meral, Belgin Petek Balcı, Feriha Özer, Özlem Çokar, Emel Oğuz Akarsu, Mithat Bedir   +6 more
core   +1 more source

Psychometric Properties of the Choosing Wisely Questions in a Large Psychiatric Sample

International Journal of Methods in Psychiatric Research, Volume 35, Issue 4, December 2026.
ABSTRACT Objectives The Choosing Wisely Questions (CWQ) support shared decision‐making and aim to reduce low‐value care, but their psychometric properties remain unclear. This study evaluated the structural validity, reliability, and item characteristics of the Swedish CWQ in a psychiatric sample.
Johan Bengtsson, Alma Andersson, Natalie Forss Lilja, Isabella Hultgren Farsani, Ellen Lissbrant, Björn Wettermark, Ida Blomqvist   +6 more
wiley   +1 more source

Antipsychotic Prescriptions for Prenatal and Postpartum Women in Japan: A Large Claims Database Study

Pharmacology Research &Perspectives, Volume 14, Issue 6, December 2026.
ABSTRACT This study aimed to evaluate the prevalence of antipsychotic prescriptions before, during, and after pregnancy in Japan, with a focus on new prescriptions and continuation after pregnancy confirmation. We conducted a claims‐based analysis using a Japanese claims database (analytic period: 2010–2022).
Ryo Obara, Takamasa Sakai, Tomofumi Ishikawa, Kei Morishita, Motohiko Adomi, Azusa Hara, Saya Kikuchi, Natsuko Kobayashi, Noriyuki Iwama, Genki Shinoda, Aoi Noda, Masatsugu Orui, Mami Ishikuro, Hiroaki Tomita, Nariyasu Mano, Shinichi Kuriyama, Taku Obara   +16 more
wiley   +1 more source

Monitoring pharmacodynamic and molecular drug targets in liquid biopsy: Exploratory study in liver cancer with modelling of EGFR Receptor engagement

British Journal of Clinical Pharmacology, Volume 92, Issue 11, Page 3902-3913, November 2026.
Abstract Aim Liquid biopsy is minimally invasive (compared with tissue biopsy) and has previously been used to generate systems data regarding drug elimination via hepatic enzymes and transporters. This study extends quantitative assessment of systems parameters in liquid biopsy to pharmacodynamic (PD) and disease markers relevant to cancer development
Zubida M. Al‐Majdoub, Armin Sepp, Amin Rostami‐Hodjegan, Brahim Achour   +3 more
wiley   +1 more source

Monitoring of Blood Clozapine Levels After a Change in Smoking Status for Patients Treated With Clozapine: A Clinical Audit From Hull Community Mental Health Team

BJPsych Open
Aims According to The Medicines and Healthcare products Regulatory Agency (MHRA) Drug safety update in August 2020 regarding clozapine, monitoring blood clozapine levels for toxicity is now advised in certain clinical situations such as when a patient ...
Kamran Mahmood, Odira Anakebe, Keshia Theobalds-Ward, Madhu Gulati   +3 more
doaj   +1 more source

Clozapine toxicity in a CYP2D6 poor metaboliser: Additive effects of haloperidol and valproate on clozapine metabolism

, 2018
Objective: To illustrate the complexities of clozapine metabolism with the use of therapeutic drug monitoring. Methods: We describe a case of clozapine toxicity in a patient with schizophrenia treated with the combination of clozapine, valproate and ...
Rena Yuan Yuan Chen, Robert Reznik, Phoebe Stanford   +2 more
core   +1 more source