Results 101 to 110 of about 62,277 (245)

A scoping review of service user experiences of potential harm in early intervention in psychosis services in the UK

British Journal of Clinical Psychology, EarlyView.
Abstract Objectives Early intervention in psychosis (EIP) services provide care for individuals experiencing first‐episode psychosis and are considered both clinically and cost‐effective. While many have positive experiences of EIP, there have also been reports of perceived harm.
Georgie Hudson, India Francis‐Crossley, Craig S. Mackie, Rachel Hiller, James B. Kirkbride, Claire Powell   +5 more
wiley   +1 more source

What is the current scope of research assessing patients’ and clinicians’ perspectives on clozapine treatment? A comprehensive scoping review

BMJ Open
Objectives Clozapine is continuously underused. The existing systematic reviews addressing barriers to clozapine prescribing primarily focus on clinical staff’s attitudes and perceived barriers to prescribing.
Jimmi Nielsen, Erik Simonsen, Ole Jakob Storebø, Michelle Iris Jakobsen, Stephen F Austin, Julie Perrine Schaug   +5 more
doaj   +1 more source

Prediction of brain clozapine and norclozapine concentrations in humans from a scaled pharmacokinetic model for rat brain and plasma pharmacokinetics [PDF]

, 2014
BACKGROUND: Clozapine is highly effective in treatment-resistant schizophrenia, although, there remains significant variability in the response to this drug.
Bies, Robert R., Cremers, Thomas I. F. H., Li, Claire H., Mulsant, Benoit H., Pollock, Bruce G., Remington, Gary, Stratford, Robert E., Velez de Mendizabal, Nieves   +7 more
core   +1 more source

Cannabigerol reverses mechanical allodynia through α2A‐adrenergic modulation of thalamocortical signaling in chemotherapy‐induced neuropathy

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Chemotherapy‐induced peripheral neuropathy (CIPN) is a prevalent and treatment‐resistant side effect of platinum‐based chemotherapy, characterised by mechanical allodynia. Cannabigerol (CBG), a non‐psychoactive cannabinoid, has shown antinociceptive potential, but its site and mechanism of action remain unclear.
Quinn W. Wade, Nathan Morris, Diana E. Sepulveda, Alonso Cortez‐Resendiz, Christopher Brandl, Jennifer E. Lausch, Mariya Starostina, Nicholas M. Graziane   +7 more
wiley   +1 more source

Differential efficacy of lithium and carbamazepine in the prophylaxis of bipolar disorder: Results of the MAP study [PDF]

, 2000
In a randomized clinical trial with an observation period of 2.5 years, the differential efficacy of lithium versus carbamazepine was compared in 171 bipolar patients (DSM-IV).
Greil, Waldemar, Kleindienst, Nikolaus
core   +1 more source

Annual Research Review: Psychosis in children and adolescents: key updates from the past 2 decades on psychotic disorders, psychotic experiences, and psychosis risk

Journal of Child Psychology and Psychiatry, Volume 66, Issue 4, Page 460-476, April 2025.
Psychosis in children and adolescents has been studied on a spectrum from (common) psychotic experiences to (rare) early‐onset schizophrenia spectrum disorders. This research review looks at the state‐of‐the‐art for research across the psychosis spectrum, from evidence on psychotic experiences in community and clinical samples of children and ...
Ian Kelleher
wiley   +1 more source

Annual Research Review: Psychosis in children and adolescents – a call to action: a commentary on Kelleher (2025)

Journal of Child Psychology and Psychiatry, Volume 66, Issue 4, Page 588-591, April 2025.
The spectrum of psychosis is highly relevant to child and adolescent mental health. Psychotic symptoms are common in children and adolescents. The onset of psychotic disorders is often preceded by neurodevelopmental problems in early childhood, and some 13% of adolescents attending specialist mental health services will later be diagnosed with a ...
James G. Scott
wiley   +1 more source

Anticholinergic Medication Burden Scales: A Systematic Review

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT Background Anticholinergic burden refers to the cumulative anticholinergic effect of all medications taken by an individual. Anticholinergic burden scales help identify patients at risk of anticholinergic adverse effects and guide prescribing. However, substantial variation exists between scales, with no gold standard identified.
Orla Vennard, Carrie Stewart, Mansi Tolia, Roy L. Soiza, Phyo K. Myint   +4 more
wiley   +1 more source

Association Between Cholinesterase Inhibitor‐Overactive Bladder Antimuscarinic Prescribing Cascade and Risk of Delirium and Falls Among Individuals Living With Dementia

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT Background Prescribing cascades occur when cholinesterase inhibitor (ChEI)‐induced urinary incontinence is misinterpreted as a new condition, leading to overactive bladder (OAB) antimuscarinic initiation. We evaluated whether the ChEI‐OAB antimuscarinic prescribing cascade was associated with delirium or falls compared with mirabegron in older
Sarah Beth Tucker, Bryan L. Love, Chijioke M. Okeke, Erin D. Zwick, Chengwen Teng, Jingkai Wei, Ibraheem M. Karaye, Saud Alsahali, Krithika Rajagopalan, Ismaeel Yunusa   +9 more
wiley   +1 more source

Olanzapine Attenuates Cue-elicited Craving for Tobacco

, 2004
Rationale: Recent biological conceptualizations of craving and addiction have implicated mesolimbic dopamine activity as a central feature of the process of addiction. Imaging, and pharmacological studies have supported a role for dopaminergic structures
Hutchinson, Kent E, Niaura, Raymond, Pickworth, Wallace B, Rutter Goodworth, Marie-Christine, Sobik, Laura, Swift, Robert   +5 more
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