Results 101 to 110 of about 39,176 (275)

Clozapine-Associated Agranulocytosis Treatment With Granulocyte Colony-Stimulating Factor/Granulocyte-Macrophage Colony-Stimulating Factor [PDF]

, 2017
PURPOSE/BACKGROUND: Clozapine is associated with hematological abnormalities, notably neutropenia, which may progress to agranulocytosis. Granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) have ...
Eromona Whiskey, Amir Krivoy, Flanagan, Robert J., Lally, John, John Lally, David M. Taylor (4342150), Robert J. Flanagan, James H. MacCabe (7955552), Fiona P. Gaughran (7955543), MacCabe, James H.; id_orcid, Aleksandar Mijovic (7955549), Aleksandar Mijovic, Mijovic, Aleksandar, David M. Taylor, Eromona Whiskey (7955540), Malik, Steffi, Gaughran, Fiona P.; id_orcid, John Lally (7896821), James H. MacCabe, Taylor, David M.; id_orcid, Steffi Malik (7955525), Whiskey, Eromona, Amir Krivoy (6667283), Steffi Malik, Robert J. Flanagan (7955546), Krivoy, Amir, Fiona P. Gaughran   +26 more
core   +1 more source

Systemic medications associate with surgically treated cataract among adults over 50 years in Finland

Acta Ophthalmologica, EarlyView.
Abstract Purpose To identify associations between systemic drugs and cataract surgery in Finland. Methods A historic cohort study based on administrative data. Endpoint event was cataract surgery. Use of drugs in question was based on redeemed prescriptions and consisted of 156 drugs.
Antti Riikonen, Jari Haukka, Tuomas Lilius, Sirpa Loukovaara   +3 more
wiley   +1 more source

CLOZAPINE AND HALOPERIDOL INCREASE THE EXPRESSION OF PED/PEA-15: A PUTATIVE NOVEL MECHANISM FOR ANTIPSYCHOTIC-RELATED DIABETES

, 2008
Schizophrenia is a serious disorder that affects 1% of the population in the United States and Europe, and is associated with a significant reduction in life expectancy that approaches 20% compared with that of the general population.
Panariello, Fabio
core  

A retrospective study of intramuscular clozapine prescription for treatment initiation and maintenance in treatment-resistant psychosis

, 2020
Background Clozapine is uniquely effective in treatment-resistant psychosis but remains underutilised, partly owing to psychotic symptoms leading to non-adherence to oral medication. An intramuscular formulation is available in the UK but outcomes remain
Whiskey, E., Dzahini, O., Shergill, S.
core  

Understanding excessive sleep in people with psychotic disorders

British Journal of Clinical Psychology, EarlyView.
Abstract Background There has been increasing attention to sleep disturbances such as insomnia in psychosis, due to its impact on symptoms, well‐being, and recovery. However, excessive sleep and extended sleep duration are common in psychosis (partly linked to sedating antipsychotic medication) and have been relatively neglected, despite plausible ...
Kate Robbins, Joanne Hodgekins, Sarah Reeve   +2 more
wiley   +1 more source

A scoping review of service user experiences of potential harm in early intervention in psychosis services in the UK

British Journal of Clinical Psychology, EarlyView.
Abstract Objectives Early intervention in psychosis (EIP) services provide care for individuals experiencing first‐episode psychosis and are considered both clinically and cost‐effective. While many have positive experiences of EIP, there have also been reports of perceived harm.
Georgie Hudson, India Francis‐Crossley, Craig S. Mackie, Rachel Hiller, James B. Kirkbride, Claire Powell   +5 more
wiley   +1 more source

Cannabigerol reverses mechanical allodynia through α2A‐adrenergic modulation of thalamocortical signaling in chemotherapy‐induced neuropathy

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Chemotherapy‐induced peripheral neuropathy (CIPN) is a prevalent and treatment‐resistant side effect of platinum‐based chemotherapy, characterised by mechanical allodynia. Cannabigerol (CBG), a non‐psychoactive cannabinoid, has shown antinociceptive potential, but its site and mechanism of action remain unclear.
Quinn W. Wade, Nathan Morris, Diana E. Sepulveda, Alonso Cortez‐Resendiz, Christopher Brandl, Jennifer E. Lausch, Mariya Starostina, Nicholas M. Graziane   +7 more
wiley   +1 more source

Drugs that act on both G protein‐coupled receptors (GPCRs) and kinases: potentiation of effects, side effects and general aspects of drug pleiotropy

British Journal of Pharmacology, EarlyView.
Abstract Background A drug designed for a specific target often interacts with multiple targets, either unintentionally or as part of its intended mechanism of action. This has been called pharmacological pleiotropy or polypharmacology. There are key endogenous ligands such as ATP, GABA and glutamate that act on various proteins in humans. Furthermore,
Hampus Ljunggren, Aleksandr Sokolov, Flavio Ballante, Robert Fredriksson, Francisco Lagunas‐Rangel, Alexander S. Hauser, Stefan Knapp, Jörgen Jonsson, Helgi B. Schiöth   +8 more
wiley   +1 more source

Clozapine for treatment-resistant schizophrenia with epilepsy: A case report. [PDF]

PCN Rep
Clozapine (CLOZ) is often avoided in treatment‐resistant schizophrenia with comorbid epilepsy due to seizure risks. We report a successful case managed through a cautious CLOZ titration guided by multimodal monitoring, including clinical scales and blood tests such as C‐reactive protein (CRP), CLOZ levels, and anti‐seizure medication (ASM) levels ...
Horinouchi T, Mito M, Ishikawa T, Nakamura Y, Ishikawa S, Hashimoto N.   +5 more
europepmc   +2 more sources

Effective and safe use of intramuscular clozapine in a patient presenting with catatonia and thrombocytopenia. [PDF]

Clozapine is the most effective medication for the management of treatment-resistant schizophrenia and schizoaffective disorder, and its discontinuation can pose significant challenges in treatment.
Thapaliya, Suresh, Whiskey, Eromona, Firdosi, Mudasir   +2 more
core   +1 more source