Results 101 to 110 of about 29,714 (222)

A Review of Virtual Twins in Physiologically‐Based Pharmacokinetic Modeling and Simulation

Clinical Pharmacology &Therapeutics, Volume 120, Issue 2, Page 324-333, August 2026.
The novel application of Virtual Twins (VT) in PBPK (VT‐PBPK) presents the opportunity to advance precision dosing and accelerate the shift from one‐size‐fits‐all to targeted, individualized treatments. This review aims to: (1) critically evaluate existing research on the use of VTs in PBPK, (2) develop a conceptual definition of VT‐PBPK, (3) describe ...
Emily Mannix, Sam Mostafa, Amin Rostami‐Hodjegan, Thomas M. Polasek, Carl M. J. Kirkpatrick   +4 more
wiley   +1 more source

Exploring Cerumen as an Alternative Matrix for Drug Detection and Quantification: Method Development and Application in Clinical Samples

Drug Testing and Analysis, Volume 18, Issue 8, Page 1065-1075, August 2026.
An LC–MS/MS method was developed for the detection of 33 psychoactive medications in cerumen (earwax) and applied to the samples of 60 psychiatric inpatient volunteers. The findings highlighted the utility of cerumen as an innovative biospecimen in clinical toxicological analysis.
Dimitrios Phaedon Kevrekidis, Helen G. Gika, Georgios Panagiotoglou, Eleni Parlapani, Pavlos Pavlidis, Nikolaos Raikos   +5 more
wiley   +1 more source

Interaction Among Microbiota, Chemical Composition, and Quality Variations in Coffea arabica Across Altitudinal Gradients During Wet Processing

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
Fermentation significantly altered the dominant bacterial genera from Sphingomonas and Pleomorphomonas (before fermentation) to Weissella and Lactobacillus (after fermentation), while Cladosporium and Fusarium remained the dominant fungal genera. Notably, non‐volatile compounds in de‐pulping coffee beans and volatile compounds of roasted coffee beans ...
Xiaojing Shen, Yamei Wu, Qi Wang, Wenhua Chen, Bintao Peng, Surui Lu, Ying Yang, Kunyi Liu, Jilai Zhang   +8 more
wiley   +1 more source

Early Developmental Neuronal Activity Impacts Oligodendrocyte Differentiation Through AMPA Receptors

Glia, Volume 74, Issue 8, August 2026.
In early brain development, neuronal activity reduces OPC differentiation. Decreased neuronal activity changes oligodendrocyte gene expression, including upregulating glutamate receptor genes. AMPA signaling regulates the final stages of OPC differentiation.
Tessa E. Allen, Graham Peet, Luis E. Gomez Wulschner, Won Chan Oh, Wendy B. Macklin   +4 more
wiley   +1 more source

Chemogenetic Activation of G12 Signaling Thickens the Epidermis With Enhanced Barrier Function

FASEB BioAdvances, Volume 8, Issue 8, August 2026.
In this study, we investigated the role of G12 signaling in the epidermis using a keratinocyte‐specific chemogenetic approach. Activation of G12 signaling promoted keratinocyte differentiation and enhanced epidermal barrier function by upregulating filaggrin, claudin‐1, and ceramide.
Nozomi Kamakura, Natsumi Hirai, Kaito Arai, Yaxin Du, Toshiaki Kogame, Yusuke Ohno, Akio Kihara, Kenji Kabashima, Asuka Inoue   +8 more
wiley   +1 more source

Comparative Clinical Trajectories Across Cannabis‐Related and Nonsubstance‐Related Psychoses

Acta Psychiatrica Scandinavica, Volume 154, Issue 2, Page 142-152, August 2026.
ABSTRACT Background Research indicates that first‐episode psychosis (FEP) with cannabis use disorder (CUD) carries a substantial disease burden, but more granular clinical trajectories of cannabis‐related psychoses remain unclear. This study examines the clinical trajectories of first clinically diagnosed FEP&CUD and cannabis‐induced psychosis (CIP) in
Antti Mustonen, Solja Niemelä, Alexander Denissoff, Antti Tanskanen, Ellenor Mittendorfer‐Rutz, Markku Lähteenvuo, Jari Tiihonen, Heidi Taipale   +7 more
wiley   +1 more source

Antipsychotic treatment in schizophrenia: balancing relapse prevention and functional recovery

Schizophrenia
Jan P. A. M. Bogers
doaj   +1 more source

Relaxation of Japan's clozapine monitoring system is urgently needed: Adding 10,000 future prescriptions may prevent up to 400 schizophrenia-related suicides and cost 1 death by agranulocytosis. [PDF]

PCN Rep
de Leon J, Kikuchi Y, Yasui-Furukori N.
europepmc   +1 more source

Clozapine-induced diarrhea: A case report and mechanistic overview. [PDF]

PCN Rep
Dastmardi S, Namazi S.
europepmc   +1 more source

Identification, reliability, and validity of drug–drug interaction checkers in chronic diseases: A systematic review

British Journal of Pharmacology, Volume 183, Issue 16, Page 4532-4561, August 2026.
Abstract Drug–drug interactions (DDIs) pose major risks in chronic disease management where polypharmacy is common. Although digital DDI tools are used widely to aid healthcare professionals, tools rely on theoretical interactions. This limitation questions their reliability and validity for clinical relevancy.
Brayden Ng Gibson, Sri Chodapuneedi, Huan Yee Koh, Sugandha Gupta, Danijela Gasevic, Anna Yuanyuan Wang, Catia Marzolini, Saye Khoo, Lorena Romero, Lachlan Dalli, Jack Janetzki, Harvey Jia Wei Koh, Stella Talic   +12 more
wiley   +1 more source