Results 121 to 130 of about 39,176 (275)

Implementing a clozapine supply service in Australian community pharmacies: barriers and facilitators

, 2019
Background: Clozapine is the most effective antipsychotic for treatment-resistant schizophrenia, although serious adverse effects such as agranulocytosis and cardiomyopathy limit its use.
Wheeler, Amanda J, Wilson, Bethany, McMillan, Sara S   +2 more
core   +1 more source

Prediabetic cardiomyopathy is attenuated by hypothalamic PVN oxytocin neuron activation

The Journal of Physiology, EarlyView.
Abstract figure legend A long‐term high‐fat, high‐fructose diet induces prediabetes with insulin resistance, hyperinsulinaemia, elevated triglycerides and metabolic‐associated steatotic liver disease (MASLD) in male rats. Animals developed prediabetic cardiomyopathy characterized by diastolic dysfunction, interstitial fibrosis and tachycardia ...
Anna Nilsson, Joan Escobar, Kira Kuraoka, Ian Venter, Cielo A. Carnate, Matthew W. Kay, David Mendelowitz, Kathryn J. Schunke   +7 more
wiley   +1 more source

Electromechanical modelling and simulation of human‐induced pluripotent stem cell‐derived cardiomyocytes predict drug‐induced contractility effects

The Journal of Physiology, EarlyView.
Abstract figure legend A study described in this paper describes a new tool for hiPSC‐CM electromechanical behaviour simulations using mathematical modelling. The model enables in silico assays making drug testing quick, comprehensive and accurate. New hiPSC‐CM models can be used as a platform to integrate in vitro and in silico findings.
Milda Folkmanaite, Xin Zhou, Andreas Koschinski, Wan‐Hua Hong, Marilù Casini, Manuel Koch, Ursula Ravens, Remi Peyronnet, Manuela Zaccolo, Blanca Rodriguez   +9 more
wiley   +1 more source

Clozapine Protects Bone Mineral Density in Female Patients with Schizophrenia

, 2012
Decreased bone mineral density (BMD) is common in patients with schizophrenia; however, the pathogenesis is unclear. Different classes of antipsychotic agents may affect BMD. This study systemically examined the effects of clozapine vs.
Lin, Chieh-hsin; Huang, Kuo-hao; Chang, Yue-cune; Huang, Yi-chen; Hsu, Wan-chih; Lin, Chun-yuan; Chou, Frank Huang-chih; Tsai, Guochuan E.; Lane, Hsien-yuan
core   +1 more source

Anatomical and functional mapping of vagal nociceptive sensory nerve subsets innervating the mouse lower airways by intersectional genetics

The Journal of Physiology, EarlyView.
Abstract figure legend We used an intersectional approach with recombinase‐expressing mice and adeno‐associated virus to map and modulate distinct nociceptive afferents in the vagal ganglia. TRPV1+P2X2+ neurons resided in the nodose ganglion (N), innervated the lungs (many projected into the alveoli) but not the trachea, and projected to the nucleus ...
Mayur J. Patil, Justin Shane Hooper, Seol‐Hee Kim, Parmvir K. Bahia, Nika Pavelkova, Sanjay S. Nair, Teresa S. Darcey, Karina V. Lurye, Meghana Madaram, Jailene Fiallo, Stephen H. Hadley, Thomas E. Taylor‐Clark   +11 more
wiley   +1 more source

A Japanese Pregnant Woman With Treatment‐Resistant Schizophrenia Who Continued Clozapine With Blood Concentration Monitoring During the Perinatal Period and Had a Healthy Baby: A Case Report

Neuropsychopharmacology Reports
Background Clozapine is known to improve the social functioning of patients with treatment‐resistant schizophrenia (TRS). In Japan, there are few reports on pregnancy and childbirth in patients treated with clozapine, and information on its effects on ...
Mariko Tsukiji, Kaori Yamazaki, Yusuke Nakata, Tsuyoshi Sasaki, Keita Idemoto, Kazuki Okada, Shingo Yamazaki, Akiko Omoto, Kaori Koga, Tomihisa Niitsu, Itsuko Ishii   +10 more
doaj   +1 more source

Antipsychotic medication for people with first episode schizophrenia: an exploratory economic analysis of alternative treatment algorithms [PDF]

Available clinical evidence suggests that the newer antipsychotics are similar to conventional antipsychotics for positive symptom control. It has been suggested that they may also be superior for negative symptoms and side effects, but the evidence for ...
Linda Davies, Shon Lewis
core  

Effect of fluvoxamine augmentation and smoking on clozapine serum concentrations

, 2019
Background: Clozapine (CLZ) is metabolized via cytochrome P450 CYP1A2 to N-desmethylclozapine (NCLZ). Smoking induces CYP1A2 thereby increasing clozapine metabolismwhereas fluvoxamine inhibits CYP1A2.
Augustin, Marc, Pfeifer, Philippe, Gründer, Gerhard, Schoretsanitis, Georgios, Liebe, Claus, Paulzen, Michael   +5 more
core   +1 more source

Switching bipolar disorder patients treated with clozapine to another antipsychotic medication: a mirror image study

, 2017
Petru Ifteni,1,2 Andreea Teodorescu,1,2 Marius Alexandru Moga,1 Alina Mihaela Pascu,1 Roxana Steliana Miclaus1,2 1Faculty of Medicine, Transilvania University of Brasov, Brasov, Romania; 2Clinical Hospital of Psychiatry and Neurology Brasov, Brasov ...
Teodorescu A, Pascu AM, Moga MA, Miclaus RS, Ifteni P   +4 more
core  

Beat‐to‐beat variability of ventricular repolarization reveals sex‐specific instability and proarrhythmic risk

The Journal of Physiology, EarlyView.
Abstract figure legend A mechanistic framework linking sex‐dependent dynamical instability to proarrhythmic risk. Sex‐specific human ventricular models show that upstream modulators, including biological sex, hormones, drugs and heart disease, promote steeper APD restitution in female than male and enhance dynamical instability.
Daisuke Sato, Lorenzo Santini, Raffaele Coppini, Eleonora Grandi   +3 more
wiley   +1 more source