Results 141 to 150 of about 39,176 (275)

Electroacupuncture Ameliorates Learning and Memory Deficits in Vascular Cognitive Impairment Rats Through Activation of the Supramammillary Nucleus–Dentate Gyrus Circuit

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
Electroacupuncture at ST36 alleviates cognitive deficits and restores hippocampal synaptic plasticity in VCI rats by activating the SuMGlu‐DG circuit. This study identifies the SuMGlu‐DG circuit as an essential mediator for the therapeutic and neuroprotective effects of acupuncture in vascular‐induced cognitive decline.
Fang Wan, Lu Wang, Qing‐Yong Wang, Jing‐Wen Yang, Cun‐Zhi Liu   +4 more
wiley   +1 more source

Restoration of Excitation‐Inhibition Balance and Improvement of Schizophrenia‐like Behavioral Deficits via Electroacupuncture

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
Ablation of nNos from Erbb4‐positive neurons induces impaired GABAergic transmission and disruption of excitatory and inhibitory balance, which further cause hyperactivity of pyramidal neurons, resulting in schizophrenia‐relevant behavioral deficits. EA treatment rescues decreased GABAergic transmission and restores excitatory and inhibitory balance by
Chaofan Wan, Yucen Xia, Jinglan Yan, Weipeng Lin, Yuanjia Zheng, Yiqiu Lin, Lin Yao, Yongjun Chen   +7 more
wiley   +1 more source

Predictors of clozapine concentration and psychiatric symptoms in patients with schizophrenia.

PLoS ONE
Clozapine has superior efficacy to other antipsychotics, especially in patients with treatment-resistant schizophrenia. However, its pharmacokinetics and pharmacodynamics vary largely among patients.
Sang-In Park, Seoyoung Kim, Kwanwoo Park, Uijeong Yu, Yunjeong Jang, Bo-Hyung Kim, Ji Hyun Lee, Euitae Kim   +7 more
doaj   +1 more source

Unrecognized clozapine-related constipation leading to fatal intra-abdominal sepsis – a case report

, 2015
Vikram Oke, Frances Schmidt, Bikash Bhattarai, Md Basunia, Chidozie Agu, Amrit Kaur, Danilo Enriquez, Joseph Quist, Divya Salhan, Vijay Gayam, Prajakta Mungikar Department of Pulmonary Medicine, Interfaith Medical Center, NY, USA Abstract: Clozapine is ...
Oke V, Agu C, Enriquez D, Gayam V, Schmidt F, Bhattarai B, Basunia M, Salhan D, Mungikar P, Kaur A, Quist J   +10 more
core  

Differential Responsiveness to Exercise and Cognitive Remediation in Physical Health in People With Schizophrenia: Results From the CORTEX‐SP Study

European Journal of Sport Science, Volume 26, Issue 6, June 2026.
ABSTRACT Non‐pharmacological interventions, such as exercise and cognitive remediation, have been widely investigated in people with schizophrenia (SZ), showing beneficial effects and supporting their role as complementary approaches to pharmacological treatment.
Mikel Tous‐Espelosin, Nagore Iriarte‐Yoller, Agurne Sampedro, Iker Lasa‐Sagaseta, Cristóbal Pavon, Natalia Ojeda, Pedro Sanchez, Javier Peña, Sara Maldonado‐Martín   +8 more
wiley   +1 more source

Heartfelt intervention: A role for PVN oxytocin neurons in the prediabetic heart

The Journal of Physiology, EarlyView.
Grace K. Nielsen, Reesa M. Wilcox, Han‐Jun Wang   +2 more
wiley   +1 more source

Clinical outcomes of mitochondrial‐enhancing nutraceutical supplementation in psychiatric disorders: A systematic review

General Psychiatry, Volume 39, Issue 3, June 2026.
ABSTRACT Background Nutraceutical supplementation targeting mitochondrial function has been proposed as a beneficial therapeutic strategy to improve physical and mental health in psychiatric patients. Aims To summarise the results of studies evaluating nutraceutical supplementation targeting mitochondrial function in patients with psychiatric disorders.
Juan Tortajada, Bengisu Kevser Bulduk, Belén Alfonso‐Landete, Paula Alcaide‐Barriga, Bernat Ballvé‐Gelonch, Glòria Garrabou, Elisabet Vilella, Yolanda Alonso, Alba Valiente‐Pallejà, Lourdes Martorell   +9 more
wiley   +1 more source

Hepatotoxicity induced by clozapine: a case report and review of literature

, 2014
Ana Isabel Wu Chou,1 Mong-Liang Lu,1,2 Winston W Shen1,2 1Department of Psychiatry, Wan-Fang Hospital, Taipei Medical University, 2Department of Psychiatry, School of Medicine, Taipei Medical University, Taipei, Taiwan Abstract: Clozapine is an ...
Lu ML, Wu Chou AI, Shen WW
core  

Evaluation of Hemoadsorption Capacity of the CytoSorb Adsorber for Toxic Doses of Diclofenac and Meloxicam in Porcine Plasma

Journal of Clinical Apheresis, Volume 41, Issue 3, June 2026.
ABSTRACT The objective of this in vitro experimental was to determine the utility of hemoadsorption (HA) using the CytoSorb adsorber to remove meloxicam and diclofenac from porcine plasma. For this purpose 12 1‐L aliquots of porcine plasma, 6 units were spiked with 293 μg/mL (262–320 μg/mL) diclofenac and 6 with 42.8 μg/mL (41.4–44.7 μg/mL) meloxicam ...
Bettina Giani, René Dörfelt, Katrin Hartmann, Florian Sänger   +3 more
wiley   +1 more source

Differential Neuronal Development in iPSC‐Derived Neural Stem Cells From Monozygotic Twin Cases With Treatment‐Resistant Schizophrenia and Discordant Responses to Clozapine

Neuropsychopharmacology Reports, Volume 46, Issue 2, June 2026.
We investigated early neuronal development using iPSCs from twins with treatment‐resistant schizophrenia discordant for clozapine response. The non‐responder exhibited more pronounced impairment in differentiation than the responder. Transcriptomic analysis revealed distinct developmental gene expression profiles, suggesting that early ...
Shotaro Kawano, Sayaka Katayama, Masaya Ogawa, Rei Endo, Naoto Ikeda, Yuuri Ikeuchi, Tomoki Mita, Hikari Takei, Nanaka Gotoda‐Nishimura, Daiki Miura, Hotaka Fukushima, Hitoshi Hashimoto, Ryota Hashimoto, Takanobu Nakazawa   +13 more
wiley   +1 more source