Results 131 to 140 of about 45,210 (266)

Loss of SHP1 in Spinal Astrocytes Triggers T‐Lymphocyte Infiltration and Nociceptive Hypersensitivity

Advanced Science, Volume 13, Issue 60, 28 October 2026.
Astrocyte‐specific SHP1 deletion disrupts astrocyte–vascular interactions and compromises BBB integrity while enhancing STAT1‐dependent CXCL10 expression. These changes synergistically promote peripheral CD4+ and CD8+ T‐cell infiltration into the SDH. The infiltrating T cells secrete IFN‐γ, which in turn activates microglia.
Lan‐Xing Yi, Lin Yang, Kang‐Li Wang, Hui‐Zhu Liu, Rui‐Ying Chen, Min Su, Xiao Xiao, Yu‐Qiu Zhang   +7 more
wiley   +1 more source

Unrecognized clozapine-related constipation leading to fatal intra-abdominal sepsis – a case report

, 2015
Vikram Oke, Frances Schmidt, Bikash Bhattarai, Md Basunia, Chidozie Agu, Amrit Kaur, Danilo Enriquez, Joseph Quist, Divya Salhan, Vijay Gayam, Prajakta Mungikar Department of Pulmonary Medicine, Interfaith Medical Center, NY, USA Abstract: Clozapine is ...
Oke V, Agu C, Enriquez D, Gayam V, Schmidt F, Bhattarai B, Basunia M, Salhan D, Mungikar P, Kaur A, Quist J   +10 more
core  

Melatonin Levels in 89 Individuals With Smith Magenis Syndrome

American Journal of Medical Genetics Part A, Volume 200, Issue 10, Page 2260-2272, October 2026.
ABSTRACT In patients with Smith–Magenis syndrome (SMS), an inverted circadian rhythm of melatonin (MT) contributes to the sleep disturbance. Standard treatment of sleep disturbance with MT often leads to extremely high daytime MT levels, resulting in even more sleep disorders. We therefore retrospectively evaluated the MT data of 89 SMS patients.
Wiebe Braam, Ann C. M. Smith
wiley   +1 more source

Dexmedetomidine Inhibition of GABA Neurons in the Ventral Tegmental Area Attenuates the Depth of Sedation in Mice

Brain and Behavior, Volume 16, Issue 10, October 2026.
Graphical Abstract ABSTRACT Introduction Dexmedetomidine is a sedative anesthetic with a unique ability to produce an arousable state of sedation. However, the neural mechanisms underlying this arousable sedation remain incompletely understood. Previous studies have implicated dopaminergic neurons in the ventral tegmental area (VTA) in mediating this ...
Jin Rao, Gaolin Qiu, Jiansheng Wang, Yuanhai Li   +3 more
wiley   +1 more source

Perspectives of non-clozapine outpatients with schizophrenia on clozapine commencement

Clozapine is continuously underutilized. Adverse side effects and the mandatory blood sampling regimen are the most frequently highlighted barriers to clozapine treatment.
Michelle Iris Jakobsen, Ole Jakob Storebø, Jimmi Nielsen, Stephen Fitzgerald Austin, Erik Simonsen   +4 more
core   +2 more sources

The Role of Anterior Insular Parvalbumin GABAergic Interneurons in Impulsivity‐Related and Alcohol‐Seeking Behaviors

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
Adolescent impulsivity is linked to increased alcohol seeking and altered activation of anterior insular PV interneurons. Chemogenetic modulation of these neurons regulates inhibitory control and alcohol‐related behaviors, highlighting their role in vulnerability to alcohol use disorder.
F. Bezerra, G. J. D. Fernandes, A. Anjos‐Santos, C. A. Favoretto, B. T. Rodolpho, P. Palombo, V. Vialou, K. P. Abrahao, F. C. Cruz   +8 more
wiley   +1 more source

Compound Ciwujia Granules Attenuate Stress‐Induced Anxiety‐ and Depression‐Like Behaviors via Inhibition of TNF‐α‐Associated Neuroinflammation in the dmPFC

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
By restoring glutamatergic neuronal activity, suppressing TNF‐related inflammatory signaling pathway, and reducing microglial overactivation in the dmPFC, CWJ ameliorated stress‐induced behavioral abnormalities. ABSTRACT Aims Compound Ciwujia Granules (CWJ) have shown antidepressant‐like effects, but the neural and molecular mechanisms underlying these
Fei Tian, Yi Li, Mengyu Dai, Yihan Guo, Bingbing Liao, Yingdan Zhang, Xin Gong, Lanying Liu, Dongdong Shi, Zhen Wang   +9 more
wiley   +1 more source

Inhibition of Cerebellar Dentate Nucleus‐Zona Incerta Glutamatergic Circuit Improves Sleep Disturbances in Chronic Temporal Lobe Epilepsy Model

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
Mice with TLE exhibit significant sleep fragmentation and reduced sleep duration, particularly during non‐rapid eye movement sleep. By employing optogenetic and chemogenetic methods to target CDN glutamatergic neurons, we observed a decrease in sleep fragmentation, an increase in overall sleep duration, and an enhancement in sleep quality among TLE ...
Liang Xia, Xuan Wang, Yingchi Zhang, Jianmin Hao, Dan Mi, Changgeng Song, Wen Jiang   +6 more
wiley   +1 more source

Antipsychotic treatment in schizophrenia: balancing relapse prevention and functional recovery

Schizophrenia
Jan P. A. M. Bogers
doaj   +1 more source

Anterior cingulate cortex neuron subtypes differentially regulate seizures

Epilepsia, Volume 67, Issue 10, Page 5531-5546, October 2026.
Abstract Objective This study aimed to investigate the regulatory roles of distinct neuronal subtypes within the anterior cingulate cortex (ACC) in acute seizures and to identify cell type‐specific mechanisms underlying seizure modulation in this region. Methods Acute seizure models were established in mice via pentylenetetrazol injection.
Ziqian Yan, Ting Tang, Kaishan Wang, Bin Fu, Zesheng Li, Mingshan Liu, Hongyi Huang, Yanfeng Yang, Qiang Zheng, Yangmin Zheng, Yongzhi Shan, Yumin Luo, Guoguang Zhao   +12 more
wiley   +1 more source