Results 11 to 20 of about 42,559 (244)
BJPsych Open, 2021 Background Clozapine is generally considered as the treatment of choice for patients with treatment-resistant schizophrenia (TRS). However, its superiority has recently been questioned because olanzapine has been suggested as non-inferior to clozapine ...
Young Tak Jo +4 more
doaj +1 more source
Clozapine use at a specialised psychiatric hospital in Johannesburg
South African Journal of Psychiatry, 2023 Background: Clozapine is the gold standard medication for treatment-resistant psychosis, with robust evidence supporting its efficacy in multiple symptom domains.
Katherine L. Ord, Belinda Marais
doaj +1 more source
Clozapine generates obsessive compulsive disorder-like behavior in mice
Molecular Brain, 2020 Clozapine is thought to induce obsessive compulsive symptoms (OCS) in schizophrenic patients. However, because OCS are often comorbid with schizophrenia regardless of clozapine treatment, it remains unclear whether clozapine can generate OCS de novo ...
Shinwon Kang +9 more
doaj +1 more source
BMC Psychiatry, 2022 Background Clozapine has the greatest efficacy for treatment-resistant schizophrenia (TRS), even though its underutilization is not uncommon across different countries.
Leeba Rezaie +4 more
doaj +1 more source
Journal of Medical Case Reports, 2021 Background Clozapine intoxication can be life-threatening. Outside of the common drug–drug interactions, tobacco smoking, and caffeine consumption, infectious and inflammatory processes are important contributors to clozapine intoxication.
Emmanuel Bebawi +2 more
doaj +1 more source
Tubulin/microtubules as novel clozapine targets
Neuropsychopharmacology Reports, 2022 Aim Clozapine is currently the only effective drug for treatment‐resistant schizophrenia; nonetheless, its pharmacological mechanism remains unclear, and its administration is limited because of severe adverse effects.
Mizuki Hino +7 more
doaj +1 more source
Infections associated with clozapine: a pharmacovigilance study using VigiBase®
Frontiers in Pharmacology, 2023 Introduction: Clozapine is primarily reserved for treatment-resistant schizophrenia due to safety concerns associated with its use. Infections have been reported with clozapine, which may lead to elevated serum levels of the drug.
Basile Chrétien +11 more
doaj +1 more source
Factors predicting serum clozapine levels in Middle Eastern patients: an observational study
BMC Psychiatry, 2022 Background Despite its superiority over other drugs for psychosis, clozapine remains underused and is associated with many clinical challenges, including difficulties in predicting therapeutic serum levels (350-600 ng/mL).
Ahmed Hassab Errasoul +1 more
doaj +1 more source
Patterns of clozapine use, misuse and disuse in a mental health area in southern Spain
European Psychiatry, 2022 Introduction Evidence supports clozapine as the best treatment in terms of efficacy, effectiveness and well-being, and as the gold standard in treatment-resistant psychotic disorders. Clozapine remains still underused, suffering initiation delays from 1.
L.I. Muñoz-Manchado +7 more
doaj +1 more source
Clozapine treatment during the COVID-19 pandemic
European Psychiatry, 2021 Introduction Clozapine is an effective antipsychotic used in treatment-resistant schizophrenia. One of the serious complications of clozapine therapy is agranulocytosis, therefore regular monitoring of the level of white blood cells (WBC) in plasma is ...
E. Dąbrowska +3 more
doaj +1 more source