Results 11 to 20 of about 63,990 (294)
Clozapine prescribing during follow-up of a first-episode psychosis cohort
European Psychiatry, 2021 Introduction Of those with schizophrenia, one third develop treatment-resistant illness. Nearly 60% of these benefit from clozapine- the only antipsychotic medication licensed in this group.
R. Rowntree +7 more
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BMC Psychiatry, 2022 Objective Clozapine may cause serious side effects despite benefits in patients with schizophrenia. Thus, an accurate understanding of the side-effect profile of clozapine is extremely important in the management of its administration to patients with ...
Yuta Kawakita +6 more
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Successful clozapine rechallenge after neutropenia using lithium carbonate : a case report
European Psychiatry, 2022 Introduction Clozapine is widely known as the drug of choice in treating refractory schizophrenia. However, clozapine prescription requires close clinical and biological monitoring to prevent harmful side effects like agranulocytosis, neutropenia and ...
D. Khattech +5 more
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Clozapine is strongly associated with the risk of pneumonia and inflammation
General Psychiatry, 2020 Clinicians need to remember that (1) systemic inflammations can increase clozapine level; (2) clozapine, by itself, can cause inflammation, particularly during titration that is too rapid for that patient; (3) clozapine may increase the risk of infection;
Chuanyue Wang +3 more
doaj +1 more source
BJPsych Open, 2021 Background Clozapine is generally considered as the treatment of choice for patients with treatment-resistant schizophrenia (TRS). However, its superiority has recently been questioned because olanzapine has been suggested as non-inferior to clozapine ...
Young Tak Jo +4 more
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BMC Psychiatry, 2022 Background Clozapine has the greatest efficacy for treatment-resistant schizophrenia (TRS), even though its underutilization is not uncommon across different countries.
Leeba Rezaie +4 more
doaj +1 more source
Sex differences in plasma clozapine and norclozapine concentrations in clinical practice and in relation to body mass index and plasma glucose concentrations: a retrospective survey [PDF]
, 2015 Background Clozapine is widely prescribed and, although effective, can cause weight gain and dysglycemia. The dysmetabolic effects of clozapine are thought to be more prevalent in women with this gender on average attaining 17 % higher plasma clozapine ...
Anderson, Simon G. +7 more
core +2 more sources
A feasibility study to investigate chemogenetic modulation of the locus coeruleus by means of single unit activity [PDF]
, 2020 Aim: Selective chemogenetic modulation of locus coeruleus (LC) neurons would allow dedicated investigation of the role of the LC-NA pathway in brain excitability and disorders such as epilepsy.
Baekelandt, Veerle +10 more
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Journal of Medical Case Reports, 2021 Background Clozapine intoxication can be life-threatening. Outside of the common drug–drug interactions, tobacco smoking, and caffeine consumption, infectious and inflammatory processes are important contributors to clozapine intoxication.
Emmanuel Bebawi +2 more
doaj +1 more source
Clozapine as add-on medication in the maintenance treatment of bipolar and schizoaffective disorders - A case series [PDF]
, 2002 Atypical neuroleptics are increasingly used in the treatment of bipolar and schizoaffective disorders. Currently, numerous controlled short-term studies are available for clozapine, olanzapine, risperidone or quetiapine, but long-term data are still ...
Amann, B. +5 more
core +1 more source