Clozapine prescribing during follow-up of a first-episode psychosis cohort
European Psychiatry, 2021 Introduction Of those with schizophrenia, one third develop treatment-resistant illness. Nearly 60% of these benefit from clozapine- the only antipsychotic medication licensed in this group.
R. Rowntree +7 more
doaj +1 more source
Successful clozapine rechallenge after neutropenia using lithium carbonate : a case report
European Psychiatry, 2022 Introduction Clozapine is widely known as the drug of choice in treating refractory schizophrenia. However, clozapine prescription requires close clinical and biological monitoring to prevent harmful side effects like agranulocytosis, neutropenia and ...
D. Khattech +5 more
doaj +1 more source
Journal of Medical Case Reports, 2021 Background Clozapine intoxication can be life-threatening. Outside of the common drug–drug interactions, tobacco smoking, and caffeine consumption, infectious and inflammatory processes are important contributors to clozapine intoxication.
Emmanuel Bebawi +2 more
doaj +1 more source
Antipsychotic medication for childhood-onset schizophrenia [PDF]
, 2007 We review the development of several new approaches for extending the performance of Brillouin based slow light systems. In particular we describe the use of cavity effects to enhance the achievable delays, gain saturation to decouple the delay and ...
Datta, Soumitra +2 more
core +3 more sources
Clozapine generates obsessive compulsive disorder-like behavior in mice
Molecular Brain, 2020 Clozapine is thought to induce obsessive compulsive symptoms (OCS) in schizophrenic patients. However, because OCS are often comorbid with schizophrenia regardless of clozapine treatment, it remains unclear whether clozapine can generate OCS de novo ...
Shinwon Kang +9 more
doaj +1 more source
Tubulin/microtubules as novel clozapine targets
Neuropsychopharmacology Reports, 2022 Aim Clozapine is currently the only effective drug for treatment‐resistant schizophrenia; nonetheless, its pharmacological mechanism remains unclear, and its administration is limited because of severe adverse effects.
Mizuki Hino +7 more
doaj +1 more source
Clozapine use at a specialised psychiatric hospital in Johannesburg
South African Journal of Psychiatry, 2023 Background: Clozapine is the gold standard medication for treatment-resistant psychosis, with robust evidence supporting its efficacy in multiple symptom domains.
Katherine L. Ord, Belinda Marais
doaj +1 more source
Association of Atypical Antipsychotics With Lipid Abnormalities in Adult Patients With Schizophrenia: A Scoping Review. [PDF]
Neuropsychopharmacol RepThis scoping review highlights the link between atypical antipsychotics and dyslipidaemia in adults with schizophrenia, identifying clozapine and olanzapine as high‐risk agents. Biomarkers and genetic polymorphisms offer promise for personalized treatment. Further research is needed on lesser‐studied drugs and predictive tools.
Abavana V, Sadiq S.
europepmc +2 more sources
Sex differences in plasma clozapine and norclozapine concentrations in clinical practice and in relation to body mass index and plasma glucose concentrations: a retrospective survey [PDF]
, 2015 Background Clozapine is widely prescribed and, although effective, can cause weight gain and dysglycemia. The dysmetabolic effects of clozapine are thought to be more prevalent in women with this gender on average attaining 17 % higher plasma clozapine ...
Anderson, Simon G. +7 more
core +2 more sources
A molecular basis for selective antagonist destabilization of dopamine D3 receptor quaternary organization [PDF]
, 2017 The dopamine D3 receptor (D3R) is a molecular target for both first-generation and several recently-developed antipsychotic agents. Following stable expression of this mEGFP-tagged receptor, Spatial Intensity Distribution Analysis indicated that a ...
Caltabiano, Gianluigi +6 more
core +2 more sources