Results 21 to 30 of about 63,990 (294)

Tubulin/microtubules as novel clozapine targets

Neuropsychopharmacology Reports, 2022
Aim Clozapine is currently the only effective drug for treatment‐resistant schizophrenia; nonetheless, its pharmacological mechanism remains unclear, and its administration is limited because of severe adverse effects.
Mizuki Hino, Takeshi Kondo, Yasuto Kunii, Junya Matsumoto, Akira Wada, Shin‐ichi Niwa, Mitsutoshi Setou, Hirooki Yabe   +7 more
doaj   +1 more source

Clozapine use at a specialised psychiatric hospital in Johannesburg

South African Journal of Psychiatry, 2023
Background: Clozapine is the gold standard medication for treatment-resistant psychosis, with robust evidence supporting its efficacy in multiple symptom domains.
Katherine L. Ord, Belinda Marais
doaj   +1 more source

An evaluation of subjective experiences, effects and overall satisfaction with clozapine treatment in a UK forensic service [PDF]

, 2015
Objectives: Patients prescribed clozapine were surveyed to assess (a) the effects, both positive and adverse, and overall satisfaction with clozapine in comparison to previously prescribed antipsychotics and (b) the relative significance of effects ...
Chaudhry, I., Chu, S., Duffy, C., Husain, N., Qurashi, I., Stephenson, P.   +5 more
core   +1 more source

Recent findings on subjective well‐being and physical, psychiatric, and social comorbidities in individuals with schizophrenia: A literature review

Neuropsychopharmacology Reports, Volume 42, Issue 4, Page 430-436, December 2022., 2022
Abstract Aim Care for people with schizophrenia is shifting the locus from long‐stay mental hospitals to nonspecialized community‐based settings. Knowledge on the care is not a sole property of psychiatric specialists. Community healthcare workers who do not specialize in psychiatry are recommended to learn more about schizophrenia.
Yupeng He, Ayako Tanaka, Taro Kishi, Yuanying Li, Masaaki Matsunaga, Shinichi Tanihara, Nakao Iwata, Atsuhiko Ota   +7 more
wiley   +1 more source

Factors predicting serum clozapine levels in Middle Eastern patients: an observational study

BMC Psychiatry, 2022
Background Despite its superiority over other drugs for psychosis, clozapine remains underused and is associated with many clinical challenges, including difficulties in predicting therapeutic serum levels (350-600 ng/mL).
Ahmed Hassab Errasoul, Mohammed A. Alarabi   +1 more
doaj   +1 more source

Patients' and relatives' assessment of clozapine treatment [PDF]

, 2001
Published version: http://journals.cambridge.org/action/displayJournal?jid ...
Angermeyer, MC, Loffler, W, Muller, P, Schulze, B, Priebe, S   +4 more
core   +1 more source

Development of individual fitness score for conformity of prescriptions to the “Guidelines For Pharmacological Therapy of Schizophrenia”

Neuropsychopharmacology Reports, Volume 42, Issue 4, Page 502-509, December 2022., 2022
Abstract Aims The Guidelines for the Pharmacotherapy of Schizophrenia were established to improve the quality of medical care, and the EGUIDE project was conducted to train clinicians on guideline usage. A quality indicator (QI) was established to measure the prevalence of the guidelines, and a survey was conducted, which revealed a gap between the ...
Ken Inada, Kentaro Fukumoto, Naomi Hasegawa, Yuka Yasuda, Hisashi Yamada, Hikaru Hori, Kayo Ichihashi, Hitoshi Iida, Kazutaka Ohi, Hiroyuki Muraoka, Fumitoshi Kodaka, Kenta Ide, Naoki Hashimoto, Jun‐ichi Iga, Kazuyoshi Ogasawara, Kiyokazu Atake, Yoshikazu Takaesu, Tatsuya Nagasawa, Hiroshi Komatsu, Tsuyoshi Okada, Ryuji Furihata, Mikio Kido, Saya Kikuchi, Chika Kubota, Manabu Makinodan, Shinichiro Ochi, Masahiro Takeshima, Hirotaka Yamagata, Junya Matsumoto, Kenichiro Miura, Masahide Usami, Taishiro Kishimoto, Toshiaki Onitsuka, Eiichi Katsumoto, Akitoyo Hishimoto, Shusuke Numata, Norio Yasui‐Furukori, Koichiro Watanabe, Ryota Hashimoto   +38 more
wiley   +1 more source

Clozapine generates obsessive compulsive disorder-like behavior in mice

Molecular Brain, 2020
Clozapine is thought to induce obsessive compulsive symptoms (OCS) in schizophrenic patients. However, because OCS are often comorbid with schizophrenia regardless of clozapine treatment, it remains unclear whether clozapine can generate OCS de novo ...
Shinwon Kang, Hyun Jong Noh, Soo Hyeon Bae, Yong-Seok Kim, Hogun Lew, Jisoo Lim, Se Joo Kim, Kyung Sue Hong, Jong-Cheol Rah, Chul Hoon Kim   +9 more
doaj   +1 more source

Leukopenia and agranulocytosis in atypical antipsychotic treatment - besides clozapine

European Psychiatry, 2021
Introduction Leukopenia and agranulocytosis are reported and dangerous haematological side-effects associated with the use of antipsychotics, mostly reported for clozapine administration.
B. Jorge, C. Pedro Fernandes, J. Carvalho   +2 more
doaj   +1 more source

The side effect profile of Clozapine in real world data of three large mental hospitals [PDF]

, 2020
Objective: Mining the data contained within Electronic Health Records (EHRs) can potentially generate a greater understanding of medication effects in the real world, complementing what we know from Randomised control trials (RCTs). We Propose a text mining approach to detect adverse events and medication episodes from the clinical text to enhance our ...
arxiv   +1 more source