Clozapine as add-on medication in the maintenance treatment of bipolar and schizoaffective disorders - A case series [PDF]
, 2002 Atypical neuroleptics are increasingly used in the treatment of bipolar and schizoaffective disorders. Currently, numerous controlled short-term studies are available for clozapine, olanzapine, risperidone or quetiapine, but long-term data are still ...
Amann, B. +5 more
core +1 more source
BMC Psychiatry, 2022 Background Clozapine has the greatest efficacy for treatment-resistant schizophrenia (TRS), even though its underutilization is not uncommon across different countries.
Leeba Rezaie +4 more
doaj +1 more source
Ligand regulation of the quaternary organization of cell surface M3 muscarinic acetylcholine receptors analyzed by fluorescence resonance energy transfer (FRET) imaging and homogenous time-resolved FRET [PDF]
, 2010 Flp-In T-REx 293 cells expressing a wild type human M muscarinic acetylcholine receptor construct constitutively and able to express a Receptor Activated Solely by Synthetic Ligand (RASSL) form of this receptor on demand maintained response to the ...
Alvarez-Curto, Elisa +3 more
core +2 more sources
Infections associated with clozapine: a pharmacovigilance study using VigiBase®
Frontiers in Pharmacology, 2023 Introduction: Clozapine is primarily reserved for treatment-resistant schizophrenia due to safety concerns associated with its use. Infections have been reported with clozapine, which may lead to elevated serum levels of the drug.
Basile Chrétien +11 more
doaj +1 more source
Locomotor hyperactivity in 14-3-3Zeta KO mice is associated with dopamine transporter dysfunction [PDF]
, 2013 Dopamine (DA) neurotransmission requires a complex series of enzymatic reactions that are tightly linked to catecholamine exocytosis and receptor interactions on pre- and postsynaptic neurons.
A Abi-Dargham +53 more
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Saliva Based Clozapine Therapeutic Drug Monitoring: A Systematic Review. [PDF]
Pharmacol Res PerspectABSTRACT Clozapine is superior in the treatment of treatment‐refractory schizophrenia but requires therapeutic drug monitoring (TDM) due to its unpredictable pharmacokinetics and dose‐dependent side effects. This systematic review evaluates saliva as a more patient‐friendly sampling strategy for clozapine TDM.
Rademaker T +4 more
europepmc +2 more sources
Reasons for admission to a general medical hospital for patients taking clozapine
Therapeutic Advances in Psychopharmacology, 2022 Background: Clozapine is associated with a diverse range of side effects. In addition, patients prescribed clozapine commonly suffer with medical comorbidities.
Siobhan Gee +4 more
doaj +1 more source
Pancreatitis following Olanzapine Therapy: A Report of Three Cases [PDF]
, 2007 CONTEXT: Atypical antipsychotic agents (clozapine, olanzapine) have been linked to metabolic effects and acute pancreatitis. CASE REPORT: We reviewed the inpatient and outpatient records of three patients who developed acute pancreatitis while being ...
Azar, Riad +3 more
core +4 more sources
Global Connectivity and Function of Descending Spinal Input Revealed by 3D Microscopy and Retrograde Transduction [PDF]
, 2018 The brain communicates with the spinal cord through numerous axon tracts that arise from discrete nuclei, transmit distinct functions, and often collateralize to facilitate the coordination of descending commands.
Blackmore, Murray G. +4 more
core +2 more sources
Patterns of clozapine use, misuse and disuse in a mental health area in southern Spain
European Psychiatry, 2022 Introduction Evidence supports clozapine as the best treatment in terms of efficacy, effectiveness and well-being, and as the gold standard in treatment-resistant psychotic disorders. Clozapine remains still underused, suffering initiation delays from 1.
L.I. Muñoz-Manchado +7 more
doaj +1 more source