Results 31 to 40 of about 42,559 (244)

Managing ciprofloxacin-clozapine interaction with immunoassay-based monitoring: A case report [PDF]

Mental Health Clinician
Whereas the interaction between clozapine and ciprofloxacin is well-documented, this case report emphasizes the importance of closely monitoring clozapine plasma concentrations during concurrent administration.
Kristin Waters, PharmD, BCPS, BCPP, Victoria Popielarz, BS, PharmD Candidate, Joseph Lumasag, BS, PharmD Candidate, Sara Wiesenfeld, BS, PharmD Candidate, Ashley Tewksbury, PharmD, BCPP   +4 more
doaj   +1 more source

LncRNA THUMPD3‐AS1 Regulates Behavioral and Synaptic Structural Abnormalities in Schizophrenia via miR‐485‐5p and ARHGAP8

Advanced Science, EarlyView.
Schizophrenia (SCZ) is linked to synaptic structural deficits driven by dysregulated noncoding RNAs. Using the novel ceRNAxis pipeline, THUMPD3‐AS1/miR‐485‐5p/ARHGAP8 is identified as a key regulator of actin cytoskeletal remodeling through noncanonical RhoB/C‐ROCK2 signaling. Modulating this axis ameliorates SCZ‐like phenotypes in mice and aligns with
Xiaojuan Gong, Lingxi Chen, Xin Guo, Anna Jiang, Yayi He, Chunxia Yan, Liang Ma, Jiayang Gao, Jinyu Zhang, Bao Zhang   +9 more
wiley   +1 more source

Patterns of C-reactive protein trends during clozapine titration and the onset of clozapine-induced inflammation: a case series of weekly and daily C-reactive protein monitoring

Frontiers in Psychiatry
BackgroundInternational guidelines for clozapine titration recommend measuring C-reactive protein (CRP) weekly for 4 weeks after clozapine initiation to prevent fatal inflammatory adverse events, including myocarditis.
Yuki Kikuchi, Yuki Kikuchi, Hiroaki Tanifuji, Sota Ueno, Yoshifumi Onuma, Masatomo Goto, Masato Ishihara, Takeshi Toraiwa, Hiroshi Komatsu, Hiroaki Tomita, Hiroaki Tomita   +10 more
doaj   +1 more source

Subicular Astrocytes Govern Seizure‐Impaired Fear Memory

Advanced Science, EarlyView.
Astrocytes in dorsal subiculum act as a critical modulator of seizure‐associated cognitive dysfunction, operating through a Ca2+‐dependent adenosine‐linked astrocyte‐neuron signaling pathway that disrupts neuronal circuit homeostasis. This research highlights the potential of astrocyte‐targeted interventions as a therapeutic strategy, moving beyond the
Yuying Shao, Jing Xi, Yuhao Sun, Yulan Li, Zhisheng Li, Wangjialu Lu, Jialu Chen, Lin Yang, Fan Fei, Heming Cheng, Li Cheng, Cenglin Xu, Zhuo Huang, Vladimir Parpura, Yi Wang, Zhong Chen   +15 more
wiley   +1 more source

TNEA Regulates Hippocampal Oscillation by Improving Inhibitory Synaptic Plasticity to Ameliorates Cognitive Impairment in Alzheimer's Disease

Advanced Science, EarlyView.
TNEA improves cognition in 5xFAD mice by modulating parvalbumin‐positive interneurons in hippocampal CA1. TNEA enhances gamma oscillations during rest and theta power during novel object recognition, restoring excitation/inhibition balance. These findings support TNEA as a minimally invasive therapy for Alzheimer's disease.
Zhongzhao Guo, Hong Ni, Yu Lu, Zhengyu Cui, Yixing Wang, Zilu Zhu, Xinyu Wei, Chenyi Xia, Ming Xu, Lixia Du, Yufang Yang, Shi Shu, Ke Wang, Zhifei Wang, Chunlei Shan, Deheng Wang   +15 more
wiley   +1 more source

HLA-DQB1 6672G>C (rs113332494) is associated with clozapine-induced neutropenia and agranulocytosis in individuals of European ancestry [PDF]

, 2021
Bettina Konte, James Walters, Dan Rujescu, Sophie E. Legge, Antonio F. Pardiñas, Dan Cohen, Munir Pirmohamed, Jari Tiihonen, Annette M. Hartmann, Jan Bogers, Jan van der Weide, Karen van der Weide, Anu Putkonen, Eila Repo‐Tiihonen, Tero Hallikainen, Edward Silva, Oddur Ingimarsson, Engilbert Sigurðsson, James L. Kennedy, Patrick F. Sullivan, Marcella Rietschel, Gerome Breen, Hreinn Stefánsson, Kāri Stefánsson, David Collier, Michael O’Donovan, Ina Giegling   +26 more
openalex   +1 more source

Stromal Cell‐Mast Cell Communication Orchestrates Anti‐Viral Immunity in the Meninges

Advanced Science, EarlyView.
This study delineates the spatial distribution and postnatal maturation of meningeal mast cells and uncovers their essential role in antiviral immunity. Using genetic models, mast cells are shown to promote CD8⁺ T cell infiltration and viral clearance via IL‐33 receptor signaling and synergistic activation by IL‐33 and ATP from infected stromal cells ...
Qingqing Li, Weijia Chen, Mengxue Sun, Xinbo Ni, Qishan Ran, Xiaoyu Hu, Fang Cao, Wenwen Zeng   +7 more
wiley   +1 more source

Influence of pharmacokinetics‐related gene polymorphisms on plasma levels of clozapine and its metabolites in Japanese patients with schizophrenia

PCN Reports
Aim Clozapine is an atypical antipsychotic drug that is most effective against treatment‐resistant schizophrenia and causes serious adverse effects, including agranulocytosis. We examined the relationships between age, sex, genetic polymorphisms, and the
Shinya Kinoshita, Hideyuki Motohashi, Keiichiro Nishida, Seiichiro Tarutani, Tetsufumi Kanazawa, Junya Nagai   +5 more
doaj   +1 more source

Clozapine Withdrawal Catatonia: A Case Series and Review of Literature

Annals of Indian Psychiatry
Background: Catatonia has been reported with withdrawal of medications. Among the various psychotropics, clozapine has been implicated to cause catatonia when abruptly withdrawn. The data regarding clozapine withdrawal catatonia are scarce and are mostly
Gopika Jagota, Sandeep Grover
doaj   +1 more source

Dose-dependent clozapine-induced skin picking and self-injurious behaviour in treatment-resistant schizophrenia

Sri Lanka Journal of Medicine, 2020
Clozapine is a second-generation antipsychotic used for treatment-resistant schizophrenia. Obsessive-compulsive symptoms induced by clozapine is a known entity.
Layani C. Rathnayake, Miyuru Chandradasa, Jayan Mendis   +2 more
doaj   +1 more source