The brattleboro rat displays a natural deficit in social discrimination that is restored by clozapine and a neurotensin analog. [PDF]
, 2009 Cognitive deficits in schizophrenia are a major source of dysfunction for which more effective treatments are needed. The vasopressin-deficient Brattleboro (BRAT) rat has been shown to have several natural schizophrenia-like deficits, including ...
Feifel, D +5 more
core +2 more sources
Obesity Science &Practice, Volume 8, Issue 6, Page 784-793, December 2022., 2022 Abstract Objective Rural veterans have high obesity rates. Yet, little is known about this population's engagement with the Veterans Affairs (VA) weight management program (MOVE!). The study objective is to determine whether MOVE! enrollment, anti‐obesity medication use, bariatric surgery use, retention, and outcomes differ by rurality for veterans ...
Kathleen M. Robinson +6 more
wiley +1 more source
Routine data linkage to identify and monitor diabetes in clozapine-treated patients with schizophrenia [PDF]
, 2016 No abstract ...
Connolly, M. +8 more
core +1 more source
Reasons for admission to a general medical hospital for patients taking clozapine
Therapeutic Advances in Psychopharmacology, 2022 Background: Clozapine is associated with a diverse range of side effects. In addition, patients prescribed clozapine commonly suffer with medical comorbidities.
Siobhan Gee +4 more
doaj +1 more source
Cannabis and schizophrenia [PDF]
, 2014 BACKGROUND Schizophrenia is a mental illness causing disordered beliefs, ideas and sensations. Many people with schizophrenia smoke cannabis, and it is unclear why a large proportion do so and if the effects are harmful or beneficial. It is also unclear
Gillies, Donna +6 more
core +1 more source
Patterns of clozapine use, misuse and disuse in a mental health area in southern Spain
European Psychiatry, 2022 Introduction Evidence supports clozapine as the best treatment in terms of efficacy, effectiveness and well-being, and as the gold standard in treatment-resistant psychotic disorders. Clozapine remains still underused, suffering initiation delays from 1.
L.I. Muñoz-Manchado +7 more
doaj +1 more source
Ligand regulation of the quaternary organization of cell surface M3 muscarinic acetylcholine receptors analyzed by fluorescence resonance energy transfer (FRET) imaging and homogenous time-resolved FRET [PDF]
, 2010 Flp-In T-REx 293 cells expressing a wild type human M muscarinic acetylcholine receptor construct constitutively and able to express a Receptor Activated Solely by Synthetic Ligand (RASSL) form of this receptor on demand maintained response to the ...
Alvarez-Curto, Elisa +3 more
core +2 more sources
Clozapine treatment during the COVID-19 pandemic
European Psychiatry, 2021 Introduction Clozapine is an effective antipsychotic used in treatment-resistant schizophrenia. One of the serious complications of clozapine therapy is agranulocytosis, therefore regular monitoring of the level of white blood cells (WBC) in plasma is ...
E. Dąbrowska +3 more
doaj +1 more source
Clinical and Translational Science, Volume 16, Issue 1, Page 62-72, January 2023., 2023 Abstract Clinical response of clozapine is closely associated with serum concentration. Although tobacco smoking is the key environmental factor underlying interindividual variability in clozapine metabolism, recent genome‐wide studies suggest that CYP1A and NFIB genetic variants may also be of significant importance, but their quantitative impact is ...
Hasan Çağın Lenk +7 more
wiley +1 more source
Antipsychotic dose escalation as a trigger for Neuroleptic Malignant Syndrome (NMS): literature review and case series report [PDF]
, 2012 Background: “Neuroleptic malignant syndrome” (NMS) is a potentially fatal idiosyncratic reaction to any medication which affects the central dopaminergic system. Between 0.5% and 1% of patients exposed to antipsychotics develop the condition.
AL Pelonero +34 more
core +3 more sources