Results 61 to 70 of about 76,424 (294)

Genetic association analysis of N-methyl-d-aspartate receptor subunit gene GRIN2B and clinical response to clozapine [PDF]

, 2016
OBJECTIVE: Approximately 30% of patients with schizophrenia fail to respond to antipsychotic therapy and are classified as having treatment-resistant schizophrenia.
Abrams, Alonso, Altar, American Psychiatric Association, American Psychiatric Association, American Psychiatric Association, Anson, Arvanov, Asztely, Ayalew, Banerjee, Barrett, Bertilsson, Black, Bleehen, Borgio, Brown, Buka, Cai, Centorrino, Chiu, Corbett, Cosgrove, Creese, Daly, Davis, Di Maria, Dorval, Dudbridge, Elkis, Emsley, Endele, Evins, Fitzgerald, Freed, Galderisi, Gauderman, Gauderman, Ghassabian, Giardino, Gomes, Gunduz-Bruce, Hagg, Hardy, Harrow, Heresco-Levy, Heresco-Levy, Hirai, Hong, Hopkins, Horacek, Hosking, Hoyer, Hwang, Javitt, Jia, Kane, Kargieman, Kay, Kay, Kennedy, Kharazia, Kohlrausch, Komuro, Kubota, Kumra, Kuryatov, Lacro, Lahiri, Lahti, Laube, Lieberman, Lindenmayer, Linn, Liu, Long, Luby, Luisada, Malhotra, Mandich, Manolio, Massey, Mata, Mayer, McAdams, McGlashan, Meltzer, Meltzer, Meshul, Miyamoto, Mortensen, Mortimer, Newman-Tancredi, Ninan, Noda, Nowak, Nyholt, Odom-White, Ossowska, Overall, Overall, Palego, Park, Paschou, Patil, Pearce, Perkins, Pickar, Pilowsky, Pinard, Price, Purcell, Purkayastha, Sadee, Sadee, Sasieni, Schiller, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Schmitt, Schotte, Seeman, Seppala, Shapiro, Solanki, St Clair, Sun, Susser, Szczepankiewicz, Tandon, Theisen, Tian, Tingley, VanLiere, Ventura, Vojvoda, Weinberg, Wittke-Thompson, Wyatt, Xia, Xu, Yamamoto, Yoo, Zhang, Zhao, Zuk   +144 more
core   +1 more source

Mother–Child Biobehavioral Synchrony and Its Association With Social Functioning in Autistic School‐Aged Children

Autism Research, EarlyView.
ABSTRACT Parent–child biobehavioral synchrony, or the concordance of behavior and physiological indicators between individuals, is theorized to support children's social development; however, this relationship has yet to be investigated in autistic children.
Carly Moser, Chih‐Hsiang Yang, Abigail L. Hogan, Amanda Fairchild, Jane Roberts, Jessica Klusek   +5 more
wiley   +1 more source

Influence of pharmacokinetics‐related gene polymorphisms on plasma levels of clozapine and its metabolites in Japanese patients with schizophrenia

PCN Reports
Aim Clozapine is an atypical antipsychotic drug that is most effective against treatment‐resistant schizophrenia and causes serious adverse effects, including agranulocytosis. We examined the relationships between age, sex, genetic polymorphisms, and the
Shinya Kinoshita, Hideyuki Motohashi, Keiichiro Nishida, Seiichiro Tarutani, Tetsufumi Kanazawa, Junya Nagai   +5 more
doaj   +1 more source

Patterns of C-reactive protein trends during clozapine titration and the onset of clozapine-induced inflammation: a case series of weekly and daily C-reactive protein monitoring

Frontiers in Psychiatry
BackgroundInternational guidelines for clozapine titration recommend measuring C-reactive protein (CRP) weekly for 4 weeks after clozapine initiation to prevent fatal inflammatory adverse events, including myocarditis.
Yuki Kikuchi, Yuki Kikuchi, Hiroaki Tanifuji, Sota Ueno, Yoshifumi Onuma, Masatomo Goto, Masato Ishihara, Takeshi Toraiwa, Hiroshi Komatsu, Hiroaki Tomita, Hiroaki Tomita   +10 more
doaj   +1 more source

Clozapine cessation

European Psychiatry, 2022
Introduction Approximately 30% of individuals diagnosed with schizophrenia suffer from treatment-resistant or refractory schizophrenia. The gold standard for treatment is clozapine.
H. Ktari, A. Ouertani, S. Madouri, A. Aissa, Y. Zgueb, U. Ouali, R. Jomli   +6 more
doaj   +1 more source

Successful Clozapine Rechallenge in a 40-Year-Old Male Patient With Paranoid Schizophrenia After Clozapine-Associated Myocarditis. [PDF]

Case Rep Psychiatry
Background Clozapine‐associated myocarditis (CAM) is the most common inflammatory adverse effect under clozapine treatment. In the absence of equally effective therapeutic alternatives for treating treatment‐resistant schizophrenia (TRS), clinicians are often faced with the question of whether to rechallenge clozapine in patients who have experienced ...
Zabel L, Ersek N, Hofmann AB, Machetanz L, Kirchebner J, Stübner S.   +5 more
europepmc   +2 more sources

Clinical pharmacology consultations and their implementation in clinical decision making

British Journal of Clinical Pharmacology, EarlyView.
Aims One of the key roles of clinical pharmacologists is to work as consultants for other medical specialties. We wanted to investigate the characteristics of clinical pharmacology consultations, compare the types of consultations from different specialties, and evaluate how well the recommendations given were followed.
Mirjam Kauppila, Janne T. Backman, Outi Lapatto‐Reiniluoto   +2 more
wiley   +1 more source

The time has come for revising the rules of clozapine blood monitoring in Europe. A joint expert statement from the European Clozapine Task Force

European Psychiatry
The European Clozapine Task Force is a group of psychiatrists and pharmacologists practicing in 18 countries under European Medicines Agency (EMA) regulation, who are deeply concerned about the underuse of clozapine in European countries.
Hélène Verdoux, Robert A. Bittner, Alkomiet Hasan, Mishal Qubad, Elias Wagner, Alexis Lepetit, Manuel Arrojo-Romero, Christian Bachmann, Marieke Beex-Oosterhuis, Jan Bogers, Andreja Celofiga, Dan Cohen, Domenico de Berardis, Marc de Hert, Carlos de Las Cuevas, Bjørn H. Ebdrup, Konstantinos N. Fountoulakis, Daniel Guinart, Dolores Keating, Miloslav Kopeček, John Lally, Judit Lazáry, Jurjen J. Luykx, Olalla Maronas Amigo, Espen Molden, Jimmi Nielsen, Brian O’Donoghue, Pierre Oswald, Flavian S. Radulescu, Christopher Rohde, Marina Sagud, Emilio J. Sanz, Ivona Šimunović Filipčić, Iris E. Sommer, Heidi Taipale, Jari Tiihonen, Heli Tuppurainen, Selene Veerman, Alina Wilkowska, Edoardo Spina, Peter Schulte   +40 more
doaj   +1 more source

Repeated Intake of Grapefruit Juice Inhibits CYP2B6, CYP2C9, CYP2C19, and CYP3A4 while Lingonberry Powder Does Not Induce Major CYP Enzymes in Humans

Clinical Pharmacology &Therapeutics, EarlyView.
Grapefruit juice is a well‐established inhibitor of cytochrome P450 (CYP) 3A4, but its effects on other CYP enzymes or organic anion transporting polypeptides (OATPs) are not fully characterized in humans. Recently, lingonberry powder was shown to induce murine CYP enzymes. We investigated the effects of lingonberry powder and grapefruit juice on seven
Laura Aurinsalo, Outi Lapatto‐Reiniluoto, Mika Kurkela, Mikko Neuvonen, Eeva Moilanen, Mikko Niemi, Aleksi Tornio, Janne T. Backman   +7 more
wiley   +1 more source

Delayed onset, protracted delirium and aspiration pneumonitis associated with a combination of clozapine and electroconvulsive therapy

Indian Journal of Psychological Medicine, 2011
Few studies reported the efficacy and safety in combination of clozapine and electroconvulsive therapy (ECT) in schizophrenia; systematic studies are lacking. Side effects like seizure, and confusional state are reported.
N Manjunatha, G S Ram Kumar, R Vidyendaran, K Muralidharan, J P John   +4 more
doaj   +1 more source