Results 71 to 80 of about 63,990 (294)

Cholinergic Degeneration and Cognitive Function in Early GBA1‐Related Parkinson's Disease

Annals of Neurology, EarlyView.
Objective The phenotype of patients with Parkinson's disease carrying GBA1 variants (GBA‐PD) suggest similarities to symptomatology associated with early cholinergic system degeneration. Therefore, this study aims to investigate the clinical features and the cholinergic innervation pattern in patients with early GBA‐PD versus those without the GBA1 ...
Sofie Slingerland, Sygrid van der Zee, Giulia Carli, Anne C. Slomp, Emile d'Angremont, Jeffrey M. Boertien, Teus van Laar   +6 more
wiley   +1 more source

Clozapine Alone versus Clozapine and Risperidone with Refractory Schizophrenia [PDF]

New England Journal of Medicine, 2006
The treatment of schizophrenia with multiple antipsychotic drugs is common, but the benefits and risks are not known.In a randomized, double-blind study, we evaluated patients with schizophrenia and a poor response to treatment with clozapine.
Stip, E, Honer, WG, MacEwan, GW, Williams, R, Thornton, AE, Chen, EYH, Chan, RCK, McKenna, PJ, PomarolClotet, E, Falkai, P, Wong, JOY, Bergmann, A, Procyshyn, R, Wasan, K   +13 more
openaire   +5 more sources

Serotonergic modulators in Alzheimer's disease: a hope in the hopeless condition

Chemistry &Biodiversity, Accepted Article.
Alzheimer disease (AD) is the main cause of dementia worldwide. AD is a progressive brain neurodegenerative disease due to genetic and environmental factors that induce a progressive accumulation of intracellular hyperphosphorylated tau protein and extracellular amyloid protein (Aβ).
Ali I. Al-Gareeb, Morkoss Fakhry, Ali K. Albuhadily, Athanasios Alexiou, Marios Papadakis, Gaber El-Saber Batiha   +5 more
wiley   +1 more source

Loxapine and Cyproheptadine Combined Limit Clozapine Rebound Psychosis and May Also Predict Clozapine Response

Case Reports in Psychiatry, 2016
Clozapine has been consistently shown to be superior to other antipsychotics in the treatment of psychosis. However, clozapine usage has been limited due to required routine blood monitoring and the potential for life threatening side effects.
Lila Aboueid, Richard H. McCarthy
doaj   +1 more source

New strategic insights into managing fungal biofilms [PDF]

, 2015
Fungal infections have dramatically increased in the last decades in parallel with an increase of populations with impaired immunity, resulting from medical conditions such as cancer, transplantation or other chronic diseases.
Borghi, Elisa, Borgo, Francesca, Morace, Giulia, Nile, Christopher, Rajendran, Ranjith, Ramage, Gordon, Sherry, Leighann   +6 more
core   +3 more sources

Impact of smoking behavior on clozapine blood levels – a systematic review and meta‐analysis [PDF]

, 2020
Objective Tobacco smoking significantly impacts clozapine blood levels and has substantial implications on individual efficacy and safety outcomes. By investigating differences in clozapine blood levels in smoking and non‐smoking patients on clozapine ...
Falkai, Peter, Hasan, Alkomiet, McMahon, Laura, Siskind, Dan, Wagner, Elias   +4 more
core   +3 more sources

Drug‐Event Pairs as Indicators for the Detection of Adverse Drug Reactions during Hospitalization in Routinely Collected Electronic Data Sources

Clinical Pharmacology &Therapeutics, EarlyView.
Adverse drug reactions (ADRs) are a common cause of morbidity and mortality in hospitalized patients. Identification of ADRs in clinical practice, surveillance and research is essential to prevent further harm. The aim of this study was to assess the likelihood of drugs contributing to clinically important inpatient adverse events, in order to provide ...
Anna Maria Wermund, Annette Haerdtlein, Wolfgang Fehrmann, Clara Weglage, Tobias Dreischulte, Ulrich Jaehde   +5 more
wiley   +1 more source

Reasons for discontinuing clozapine: a cohort study of patients commencing treatment [PDF]

, 2016
Background Clozapine is uniquely effective in the management of treatment-resistant schizophrenia (TRS). However, a substantial proportion of patients discontinue treatment and this carries a poor prognosis.
Downs, Johnny, Hamshere, Marian L., Hayes, Richard D., Legge, Sophie, McCabe, James H., O'Donovan, Michael Conlon, Owen, Michael John, Walters, James Tynan Rhys   +7 more
core   +2 more sources

Multianalyte Approach—Including Automated Preparation of Calibrators—for Validated Quantification of 82 Drugs in Whole Blood by Liquid Chromatography–Tandem Mass Spectrometry

Drug Testing and Analysis, EarlyView.
In forensic bioanalysis, often multianalyte approaches are used given their increased effectiveness but can be difficult to develop and maintain in the laboratory, for example, in terms of calibrator solution preparation. A fast, simple, and robust liquid chromatography–tandem mass spectrometry (LC–MS/MS) method for the quantification of 82 classic ...
Andrea E. Steuer, Maja Keller, Thomas Kraemer, Sandra N. Poetzsch   +3 more
wiley   +1 more source

Retrospective evaluation of sociodemographic and clinical characteristics of patients with schizophrenia receiving clozapine monotherapy and clozapine combined with different antipsychotics

European Psychiatry
Introduction Schizophrenia is a chronic mental disorder and clozapine is an atypical antipsychotic that can be used in treatment-resistant schizophrenia patients.
E. Yıldız, S. N. İspir, H. R. Demirel, S. Odabaş Ünal, M. Aydın   +4 more
doaj   +1 more source