Results 71 to 80 of about 73,615 (295)
Clozapine Alone versus Clozapine and Risperidone with Refractory Schizophrenia [PDF]
New England Journal of Medicine, 2006 The treatment of schizophrenia with multiple antipsychotic drugs is common, but the benefits and risks are not known.In a randomized, double-blind study, we evaluated patients with schizophrenia and a poor response to treatment with clozapine.
Stip, E +13 more
openaire +5 more sources
Recent Saccadic Eye Movement Research Uncovers Patterns of Cognitive Dysfunction in Schizophrenia. [PDF]
, 2001 The frontal cortex and the subcortical areas of the brain play a major role in the control of thought and action. Eye movements are increasingly used in neuropsychological research to explore the executive and sensorimotor functions of such neural ...
Broerse, Annelies, Crawford, Trevor J.
core
Patients' and relatives' assessment of clozapine treatment [PDF]
, 2001 Published version: http://journals.cambridge.org/action/displayJournal?jid ...
Angermeyer, MC +4 more
core +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aim Drugs with anticholinergic effects are often considered as potentially inappropriate medications, especially for older patients, and deprescribing such drugs may improve cognitive function. The aim was to investigate the effectiveness of counselling on drug risks as part of a multimodal intervention to prevent cognitive decline. Methods The AgeWell.
Laura K. Lepenies +14 more
wiley +1 more source
The potential influence of estrogen-containing oral contraception on clozapine metabolism in a patient with known pharmacogenomic status [PDF]
Mental Health ClinicianClozapine is primarily metabolized via cytochrome P450(CYP)1A2 and to a lesser extent CYP3A4, CYP2C19, and CYP2D6. Metabolic inhibitors of clozapine, such as fluvoxamine and ciprofloxacin, are important to recognize to avoid adverse drug events. Estrogen-
Alyssa K. Kuhn +4 more
doaj +1 more source
Automated identification of Fos expression [PDF]
, 2001 The concentration of Fos, a protein encoded by the immediate-early gene c-fos, provides a measure of synaptic activity that may not parallel the electrical activity of neurons.
Cherkerzian, S. +7 more
core +1 more source
Chemistry – A European Journal, EarlyView.The development of broadly useful C‐P cross‐couplings of (hetero)aryl chlorides and HP(O)(R/OR)2 nucleophiles by use of nickel/DalPhos‐based catalysts is described, along with findings from DFT studies that confirm the preference for C‐P bond formation in this system arising from three‐cantered reductive elimination through substrate PV pathways ...
Michael J. Cotnam +5 more
wiley +1 more source
Case Reports in Psychiatry, 2016 Clozapine has been consistently shown to be superior to other antipsychotics in the treatment of psychosis. However, clozapine usage has been limited due to required routine blood monitoring and the potential for life threatening side effects.
Lila Aboueid, Richard H. McCarthy
doaj +1 more source
The brattleboro rat displays a natural deficit in social discrimination that is restored by clozapine and a neurotensin analog. [PDF]
, 2009 Cognitive deficits in schizophrenia are a major source of dysfunction for which more effective treatments are needed. The vasopressin-deficient Brattleboro (BRAT) rat has been shown to have several natural schizophrenia-like deficits, including ...
Feifel, D +5 more
core +2 more sources
Clinical Pharmacology &Therapeutics, EarlyView.Accurate prediction of oral drug absorption in humans is essential for early drug development; however, physiologically relevant human models are lacking. This study aims to comprehensively assess the EpiIntestinal™, a human primary intestinal 3D model, for its ability to predict oral absorption (Fa), intestinal availability (Fg), CYP3A4 induction, and
Paresh P. Chothe +4 more
wiley +1 more source