Bacterial ClpP Protease Is a Potential Target for Methyl Gallate [PDF]
Frontiers in Microbiology, 2021 Methyl gallate (MG) is an effective microbicide with great potential application in the integrated management of plant diseases and an important potential drug for clinical application. However, its target remains unknown.
Dehong Zheng +4 more
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Cellular functions of the ClpP protease impacting bacterial virulence [PDF]
Frontiers in Molecular Biosciences, 2022 Proteostasis mechanisms significantly contribute to the sculpting of the proteomes of all living organisms. ClpXP is a central AAA+ chaperone-protease complex present in both prokaryotes and eukaryotes that facilitates the unfolding and subsequent ...
Mazen E. Aljghami +5 more
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Effects of ClpP protease on biofilm formation of Enterococcus faecalis [PDF]
Journal of Applied Oral Science, 2021 Enterococcus faecalis (E. faecalis), one of the main pathogens responsible for refractory periapical periodontitis and nosocomial infections, exhibits markedly higher pathogenicity in biofilms. Objectives Studies have shown that caseinolytic protease P
Ying FENG +4 more
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Mitochondrial Protease ClpP: Cancer Marker and Drug Target [PDF]
PharmaceuticalsBackground: The human mitochondrial ClpP is a serine protease located in the mitochondrial matrix responsible for degrading short lived regulatory proteins as well as misfolded or damaged proteins, thereby maintaining cellular homeostasis.
Domenico Armenise +8 more
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ClpP Protease, a Promising Antimicrobial Target. [PDF]
Int J Mol Sci, 2019 The caseinolytic protease proteolytic subunit (ClpP) is a serine protease playing an important role in proteostasis of eukaryotic organelles and prokaryotic cells. Alteration of ClpP function has been proved to affect the virulence and infectivity of a number of pathogens.
Moreno-Cinos C +5 more
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Development of Antibiotics That Dysregulate the Neisserial ClpP Protease. [PDF]
ACS Infect Dis, 2020 Evolving antimicrobial resistance has motivated the search for novel targets and alternative therapies. Caseinolytic protease (ClpP) has emerged as an enticing new target since its function is conserved and essential for bacterial fitness, and because its inhibition or dysregulation leads to bacterial cell death.
Binepal G +14 more
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Mechanism of allosteric activation in human mitochondrial ClpP protease. [PDF]
Proc Natl Acad Sci U S AAbstractHuman ClpP protease contributes to mitochondrial protein quality control by degrading misfolded proteins. ClpP is overexpressed in cancers such as acute myeloid leukemia (AML), where its inhibition leads to the accumulation of damaged respiratory chain subunits and cell death.
Goncalves MM +12 more
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ClpP protease modulates bacterial growth, stress response, and bacterial virulence in Brucella abortus [PDF]
Veterinary Research, 2023 The process of intracellular proteolysis through ATP-dependent proteases is a biologically conserved phenomenon. The stress responses and bacterial virulence of various pathogenic bacteria are associated with the ATP-dependent Clp protease. In this study,
Dongjie Sun +11 more
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Disrupting α-Synuclein–ClpP interaction restores mitochondrial function and attenuates neuropathology in Parkinson’s disease models [PDF]
Molecular NeurodegenerationBackground Mitochondrial dysfunction and α-Synuclein (αSyn) aggregation are defining features of Parkinson’s disease (PD), yet the mechanistic link between them remains poorly understood.
Di Hu, Xiaoyan Sun, Xin Qi
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The ClpP protease is required for the stress tolerance and biofilm formation in Actinobacillus pleuropneumoniae. [PDF]
PLoS ONE, 2013 In the respiratory tract and lung tissue, a balanced physiological response is essential for Actinobacillus pleuropneumoniae to survive various types of challenges.
Fang Xie +5 more
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