Results 161 to 170 of about 3,616 (191)

MecA: A Multifunctional ClpP-Dependent and Independent Regulator in Gram-Positive Bacteria. [PDF]

Mol Microbiol
Wen ZT, Ellepola K, Wu H.
europepmc   +1 more source

Targeting mitochondrial ClpP: structural insights and therapeutic potential of ClpP agonists in cancer therapy. [PDF]

Oncol Rev
Kong M, Yu Y, Shao S, Zhang C.
europepmc   +1 more source

Cell Sizes Matter for Industrial Bioproduction, a Case of Polyhydroxybutyrate. [PDF]

Adv Sci (Weinh)
Chen YL, Liu X, Zhang LZ, Yang JS, Guo WK, Zheng S, Wang JL, Wu FQ, Yan X, Wu Q, Chen GQ.   +10 more
europepmc   +1 more source

Structural insights into the Pseudomonas aeruginosa ClpP1•ClpP2 heterocomplex and its interactions with the AAA+ ClpX unfoldase. [PDF]

Protein Sci
Ghanbarpour A, Zhang JJ, Davis JH, Baker TA, Sauer RT.   +4 more
europepmc   +1 more source

Molecular Glue-like Degraders of TEM β-Lactamases by Periplasmic Protease DegP

Taylor EK, Barbosa PS, Kadambi T, Eisele F, Moura ECCM, Walsh TR, Isom GL, Lanyon-Hogg T.   +7 more
europepmc   +1 more source

Degradation of MinD Oscillator Complexes by Escherichia coli ClpXP [PDF]

Journal of Biological Chemistry, 2021
MinD is a cell division ATPase in Escherichia coli that oscillates from pole to pole and regulates the spatial position of the cell division machinery. Together with MinC and MinE, the Min system restricts assembly of the FtsZ-ring to midcell, oscillating between the opposite ends of the cell and preventing FtsZ-ring misassembly at the poles.
Jodi L Camberg, Colby Ferreira, Josiah J Morrison   +2 more
exaly   +6 more sources

The ClpXP Protease Contributes to Staphylococcus aureus Pneumonia [PDF]

Journal of Infectious Diseases, 2020
Abstract Staphylococcus aureus is a leading cause of pneumonia. We show here that the ClpXP protease involved in protein turnover is important for pathogenesis in a murine model of acute pneumonia. Staphylococcus aureus lacking this protease is attenuated in vivo, being rapidly cleared from the airway and leading to decreased immune ...
Dane Parker, Lavoisier Akoolo
exaly   +3 more sources

Discovery of Antibacterial Cyclic Peptides That Inhibit the ClpXP Protease [PDF]

Protein Science, 2007
AbstractA method to rapidly screen libraries of cyclic peptides in vivo for molecules with biological activity has been developed and used to isolate cyclic peptide inhibitors of the ClpXP protease. Fluorescence activated cell sorting was used in conjunction with a fluorescent reporter to isolate cyclic peptides that inhibit the proteolysis of tmRNA ...
Kenneth C Keiler, John W Tomsho, Bryan J Venters   +2 more
exaly   +3 more sources

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A Specificity-Enhancing Factor for the ClpXP Degradation Machine

Science, 2000
Events that stall bacterial protein synthesis activate the ssrA-tagging machinery, resulting in resumption of translation and addition of an 11-residue peptide to the carboxyl terminus of the nascent chain. This ssrA-encoded peptide tag marks the incomplete protein for degradation by the energy-dependent ClpXP protease.
I, Levchenko, M, Seidel, R T, Sauer, T A, Baker   +3 more
openaire   +2 more sources

Alternating Translocation of Protein Substrates From Both Ends of ClpXP Protease [PDF]

EMBO Journal, 2002
In ClpXP protease complexes, hexameric rings of the ATP-dependent ClpX chaperone stack on one or both faces of the double-heptameric rings of ClpP. We used electron microscopy to record the initial binding of protein substrates to ClpXP and their accumulation inside proteolytically inactive ClpP.
Joaquin Ortega, Alasdair C. Steven, Michael R Maurizi   +2 more
exaly   +3 more sources