Results 1 to 10 of about 7,487 (147)

Unraveling proteomic chaos by independent component analysis—ClpX proficiency promotes the iron and oxygen limitation responses of Staphylococcus aureus and affects the intracellular bacterial behavior [PDF]

mSystems
In the opportunistic pathogen Staphylococcus aureus, protein homeostasis is largely mediated by the caseinolytic protease (Clp) system. The proteases ClpXP and ClpCP are crucial for general and targeted proteolysis, which rely on the unfoldases ClpX and ...
Larissa M. Busch, Hannes Wolfgramm, Supradipta De, Christian Hentschker, Manuela Gesell Salazar, Meike Kröber, Celina Hopp, Marie-Sofie Illenseher, Alexander Ganske, Stephan Michalik, Alexander Reder, Sven Hammerschmidt, Dorte Frees, Ulf Gerth, Kristin Surmann, Ulrike Mäder, Uwe Völker   +16 more
doaj   +2 more sources

Differential contributions of ClpX and ClpP to pulmonary virulence in classical and hypervirulent Klebsiella pneumoniae [PDF]

Infection and Immunity
Klebsiella pneumoniae is an opportunistic Gram-negative pathogen and a common cause of antibiotic-resistant infections including neonatal sepsis and hospital-acquired pneumonia. K.
Nathan M. Lin, Emily C. Marino, Jordan M. Schlotmann, David A. Rosen   +3 more
doaj   +2 more sources

The Cell Wall Polymer Lipoteichoic Acid Becomes Nonessential in Staphylococcus aureus Cells Lacking the ClpX Chaperone [PDF]

mBio, 2016
Lipoteichoic acid (LTA) is an important cell wall component of Gram-positive bacteria and a promising target for the development of vaccines and antimicrobial compounds against Staphylococcus aureus.
Kristoffer T. Bæk, Lisa Bowman, Charlotte Millership, Mia Dupont Søgaard, Volkhard Kaever, Pia Siljamäki, Kirsi Savijoki, Pekka Varmanen, Tuula A. Nyman, Angelika Gründling, Dorte Frees   +10 more
doaj   +5 more sources

Glaesserella parasuis ClpX participates in stress tolerance and contributes to bacterial pathogenicity [PDF]

Microbiology Spectrum
The ClpX gene in bacteria, which plays a key role in adaptation to various environmental stresses, is associated with pathogenicity. However, its role in conferring external environmental stress resistance in Glaesserella parasuis remains unclear.
Manman Xu, Youqiao Fang, Bohong Li, Wenbin Wei, Zesong Wang, Qi Cao, Chen Tan, Ruicheng Yang, Huanchun Chen, Xiangru Wang   +9 more
doaj   +2 more sources

Requirement of ClpX for CtsR dissociation from its operator elements upon heat stress in Bacillus subtilis [PDF]

Frontiers in Microbiology
A sudden increase in temperature triggers Bacillus subtilis to activate expression of stress-specific heat shock proteins of the CtsR (class three stress gene repressor) regulon to withstand the adverse conditions.
Marco Harms, Chelsea Kaden, Larissa M. Busch, Vishnu M. Dhople, Ulf Gerth, Manuela Gesell Salazar, Stephan Michalik, Zhanetta Zhatarova, Zhanetta Zhatarova, Uwe Völker, Alexander Reder   +10 more
doaj   +2 more sources

Identification of intracellular target of antimicrobial peptide EWAMP-R in bacteria [PDF]

Communications Biology
Antimicrobial peptides (AMPs) exhibit diverse antibacterial mechanisms. To elucidate the intracellular targets of the novel AMP, EWAMP-R, we generate EWAMP-R-resistant strains of Escherichia coli and Staphylococcus aureus. In E.
Yizhao Wu, Hao Tang, Puguo Hao, Yunxiang Xu, Yifan Zhang, Muyuan Wang, Rui Jiang, Jibao Jiang, Qi Zhao, Yinsheng Li   +9 more
doaj   +2 more sources

Proteomic analysis of the regulatory networks of ClpX in a model cyanobacterium Synechocystis sp. PCC 6803

Frontiers in Plant Science, 2022
Protein homeostasis is tightly regulated by protein quality control systems such as chaperones and proteases. In cyanobacteria, the ClpXP proteolytic complex is regarded as a representative proteolytic system and consists of a hexameric ATPase ClpX and a
Yumeng Zhang, Yumeng Zhang, Yumeng Zhang, Yaqi Wang, Yaqi Wang, Yaqi Wang, Wei Wei, Wei Wei, Wei Wei, Min Wang, Shuzhao Jia, Mingkun Yang, Mingkun Yang, Mingkun Yang, Feng Ge, Feng Ge, Feng Ge   +16 more
doaj   +3 more sources

Spx inhibits expression of the SwrA•DegU master flagellar activator in Bacillus subtilis [PDF]

Journal of Bacteriology
Flagella are trans-envelope nanomachines expressed from genes organized in a complex regulatory hierarchy governed at the highest level by transcription factors called master activators. The master activator of flagellar biosynthesis in Bacillus subtilis
Abigail E. Jackson, Stephen G. Olney, Ayushi Mishra, Daniel B. Kearns   +3 more
doaj   +2 more sources

The ClpXP protease and the ClpX unfoldase control virulence, cell division, and autolysis in Streptococcus pneumoniae [PDF]

Microbiology Spectrum
In all living cells, molecular chaperones and ATP-dependent proteases are essential for protein homeostasis. The ClpXP protease is a chaperone-protease complex conserved between bacteria and mitochondria.
Viktor H. Mebus, Supradipta De, Larissa M. Busch, Manuela Gesell Salazar, Rabea Schlüter, Uwe Völker, Sven Hammerschmidt, Dorte Frees   +7 more
doaj   +2 more sources

A toxin/antitoxin system targeting the replication sliding-clamp induces competence in Streptococcus pneumoniae. [PDF]

PLoS Genetics
Streptococcus pneumoniae is a pathogenic bacterium capable of entering a cellular differentiation state, called competence, which enables it to acquire new genetic functions by natural transformation, as well as physiological functions such as tolerance ...
Mickaël Maziero, Dimitri Juillot, Isabelle Mortier-Barrière, Rut Carballido-Lopez, Nathalie Campo, Pierre Genevaux, Patricia Bordes, Patrice Polard, Mathieu Bergé   +8 more
doaj   +2 more sources