Results 1 to 10 of about 4,851 (193)

Glaesserella parasuis ClpX participates in stress tolerance and contributes to bacterial pathogenicity [PDF]

Microbiology Spectrum
The ClpX gene in bacteria, which plays a key role in adaptation to various environmental stresses, is associated with pathogenicity. However, its role in conferring external environmental stress resistance in Glaesserella parasuis remains unclear.
Xiangru Wang, Huanchun Chen, Chen Tan
exaly   +4 more sources

Differential contributions of ClpX and ClpP to pulmonary virulence in classical and hypervirulent Klebsiella pneumoniae [PDF]

Infection and Immunity
Klebsiella pneumoniae is an opportunistic Gram-negative pathogen and a common cause of antibiotic-resistant infections including neonatal sepsis and hospital-acquired pneumonia. K.
Nathan M. Lin, Emily C. Marino, Jordan M. Schlotmann, David A. Rosen   +3 more
doaj   +2 more sources

ClpC1-dependent iron homeostasis underlies mycobacterial defense against oxygen-driven Fenton reaction during reactivation [PDF]

Microbiology Spectrum
The caseinolytic protease (Clp) system, which is highly conserved and essential for protein homeostasis in mycobacteria, comprises the ClpP1P2 proteolytic core and the essential ATPases ClpC1 and ClpX.
Mingzhe Chi, Yuqing Zheng, Wenkai Zheng, Youran Chen, Bohong Zhou, Jiayu Chen, Jiacheng Bai, Yuchang Di, Xuelian Zhang   +8 more
doaj   +2 more sources

Unraveling proteomic chaos by independent component analysis—ClpX proficiency promotes the iron and oxygen limitation responses of Staphylococcus aureus and affects the intracellular bacterial behavior [PDF]

mSystems
In the opportunistic pathogen Staphylococcus aureus, protein homeostasis is largely mediated by the caseinolytic protease (Clp) system. The proteases ClpXP and ClpCP are crucial for general and targeted proteolysis, which rely on the unfoldases ClpX and ...
Larissa M. Busch, Hannes Wolfgramm, Supradipta De, Christian Hentschker, Manuela Gesell Salazar, Meike Kröber, Celina Hopp, Marie-Sofie Illenseher, Alexander Ganske, Stephan Michalik, Alexander Reder, Sven Hammerschmidt, Dorte Frees, Ulf Gerth, Kristin Surmann, Ulrike Mäder, Uwe Völker   +16 more
doaj   +2 more sources

Components of the Clp complex are required for sporangium formation and dehiscence in Actinoplanes missouriensis [PDF]

Journal of Bacteriology
The actinomycete Actinoplanes missouriensis forms terminal sporangia that contain a few hundred spores. When immersed in water, the sporangium opens to release spores, which start swimming using flagella, via a process referred to as sporangium ...
Ryota Suzuki, Manato Maruko, Remi Suzuki, Takeaki Tezuka, Yasuo Ohnishi   +4 more
doaj   +2 more sources

Requirement of ClpX for CtsR dissociation from its operator elements upon heat stress in Bacillus subtilis [PDF]

Frontiers in Microbiology
A sudden increase in temperature triggers Bacillus subtilis to activate expression of stress-specific heat shock proteins of the CtsR (class three stress gene repressor) regulon to withstand the adverse conditions.
Marco Harms, Chelsea Kaden, Larissa M. Busch, Vishnu M. Dhople, Ulf Gerth, Manuela Gesell Salazar, Stephan Michalik, Zhanetta Zhatarova, Zhanetta Zhatarova, Uwe Völker, Alexander Reder   +10 more
doaj   +2 more sources

CLPX acquires an iron-sulfur cluster to sustain mitochondrial proteostasis in cancer cells [PDF]

Nature Communications
Mitochondrial proteostasis-maintaining mechanisms are crucial for protecting cells from the toxicity of misfolded protein accumulation. Although excessive stress is known to inactivate these mechanisms and thereby induce mitophagy in cancer cells, the ...
Chengquan Huang, Yixue Zhang, Han Gao, Yuxin Song, Shunchang Hu, Chaoyue Sun, Shiwen Duan, Dongxiao Ma, Xiumei Jiang, Gang Liu   +9 more
doaj   +2 more sources

Identification of intracellular target of antimicrobial peptide EWAMP-R in bacteria [PDF]

Communications Biology
Antimicrobial peptides (AMPs) exhibit diverse antibacterial mechanisms. To elucidate the intracellular targets of the novel AMP, EWAMP-R, we generate EWAMP-R-resistant strains of Escherichia coli and Staphylococcus aureus. In E.
Yizhao Wu, Hao Tang, Puguo Hao, Yunxiang Xu, Yifan Zhang, Muyuan Wang, Rui Jiang, Jibao Jiang, Qi Zhao, Yinsheng Li   +9 more
doaj   +2 more sources

ClpX-dependent regulatory pathway exacerbates Streptococcus pyogenes pathogenesis in diabetic skin infection [PDF]

mBio
Diabetes is associated with impaired immune function and increased susceptibility to severe bacterial infections, yet the pathogen-encoded mechanisms that exacerbate disease in this context remain poorly defined.
Shuiqiao Liu, Anne L. Rosen, Benjamin S. Olson, Yongke Lu, Suzanne Hickerson, Andrew L. Kau, Scott J. Hultgren, Michael G. Caparon, Wei Xu   +8 more
doaj   +2 more sources

Spx inhibits expression of the SwrA•DegU master flagellar activator in Bacillus subtilis [PDF]

Journal of Bacteriology
Flagella are trans-envelope nanomachines expressed from genes organized in a complex regulatory hierarchy governed at the highest level by transcription factors called master activators. The master activator of flagellar biosynthesis in Bacillus subtilis
Abigail E. Jackson, Stephen G. Olney, Ayushi Mishra, Daniel B. Kearns   +3 more
doaj   +2 more sources