Results 11 to 20 of about 4,851 (193)

Mycobacterium tuberculosis ClpX interacts with FtsZ and interferes with FtsZ assembly.

PLoS ONE, 2010
FtsZ assembly at the midcell division site in the form of a Z-ring is crucial for initiation of the cell division process in eubacteria. It is largely unknown how this process is regulated in the human pathogen Mycobacterium tuberculosis.
Renata Dziedzic, Manjot Kiran, Przemyslaw Plocinski, Malgorzata Ziolkiewicz, Anna Brzostek, Meredith Moomey, Indumati S Vadrevu, Jaroslaw Dziadek, Murty Madiraju, Malini Rajagopalan   +9 more
doaj   +4 more sources

Role of ClpX and MsrA/B in the Oxidative and Cell Wall Stress Response in Bacillus anthracis Sterne [PDF]

MicrobiologyOpen
ClpX functions as a component of the ClpXP protease, a conserved intracellular protease that regulates protein turnover, stress responses, and virulence in multiple bacterial species.
Aeron B. Pennington, Salina Hona, Josey I. Austin, Kelsey C. Waite, Mikaela D. Stewart, Shauna M. McGillivray   +5 more
doaj   +3 more sources

Proteomic analysis of the regulatory networks of ClpX in a model cyanobacterium Synechocystis sp. PCC 6803

Frontiers in Plant Science, 2022
Protein homeostasis is tightly regulated by protein quality control systems such as chaperones and proteases. In cyanobacteria, the ClpXP proteolytic complex is regarded as a representative proteolytic system and consists of a hexameric ATPase ClpX and a
Yumeng Zhang, Yumeng Zhang, Yumeng Zhang, Yaqi Wang, Yaqi Wang, Yaqi Wang, Wei Wei, Wei Wei, Wei Wei, Min Wang, Shuzhao Jia, Mingkun Yang, Mingkun Yang, Mingkun Yang, Feng Ge, Feng Ge, Feng Ge   +16 more
doaj   +2 more sources

The chaperone ClpX stimulates expression of Staphylococcus aureus protein A by Rot dependent and independent pathways. [PDF]

PLoS ONE, 2010
The Clp ATPases (Hsp100) constitute a family of closely related proteins that have protein reactivating and remodelling activities typical of molecular chaperones.
Lotte Jelsbak, Hanne Ingmer, Lukás Valihrach, Marianne Thorup Cohn, Mie H G Christiansen, Birgitte H Kallipolitis, Dorte Frees   +6 more
doaj   +2 more sources

CLPX and CLPP proteins are required for regulation of ALAS2

, 2021
Heme synthesis consists of a series of eight enzymatic steps that result in the synthesis of porphyrin products, which in turn can be used to generate other tetrapyrrole compounds. In late-stage erythropoiesis, these precursors can be converted into its terminal product, heme.
Carter, Stashauna S.
openaire   +3 more sources

Distribution of the clpX gene in Brachyspira species and reactivity of recombinant Brachyspira pilosicoli ClpX with sera from mice and humans [PDF]

Journal of Medical Microbiology, 2007
Previously, aclpXgene encoding a predicted 67 kDa membrane-associated ATPase subunit of the Clp protease (ClpX) was identified in a porcine strain (95/1000) of the intestinal spirochaeteBrachyspira pilosicoli.In the current study, the distribution of this largeclpXgene was investigated in a collection of strains representing all sevenBrachyspiraspp ...
Movahedi, A., Hampson, D.J.
openaire   +3 more sources

Diverse nature of ClpX degradation motifs in Streptococcus mutans

Microbiology Spectrum
Protein homeostasis is an essential process that depends on concerted effort of different proteins involved in proper protein folding, deciding the fate of misfolded proteins by either refolding them into their proper conformation or degrading the ...
Vivek Gurung, Saswati Biswas, Indranil Biswas   +2 more
doaj   +3 more sources

The role of ClpX in erythropoietic protoporphyria

Hematology, Transfusion and Cell Therapy, 2018
Hemoglobin is an essential biological component of human physiology and its production in red blood cells relies upon proper biosynthesis of heme and globin protein.
Jared C. Whitman, Barry H. Paw, Jacky Chung   +2 more
doaj   +6 more sources

The ClpXP protease and the ClpX unfoldase control virulence, cell division, and autolysis in Streptococcus pneumoniae [PDF]

Microbiology Spectrum
In all living cells, molecular chaperones and ATP-dependent proteases are essential for protein homeostasis. The ClpXP protease is a chaperone-protease complex conserved between bacteria and mitochondria.
Viktor H. Mebus, Supradipta De, Larissa M. Busch, Manuela Gesell Salazar, Rabea Schlüter, Uwe Völker, Sven Hammerschmidt, Dorte Frees   +7 more
doaj   +2 more sources

Structural basis of the AlgU-MucAcyto interaction and SspB-mediated degradation in Pseudomonas aeruginosa stress response [PDF]

mBio
In Pseudomonas aeruginosa, the sigma factor AlgU functions as a critical stress-responsive regulator governing essential physiological processes. This study assessed algU-dependent phenotypes through targeted gene knockout, including effects on alginate ...
Tao Li, Yingzhi Wang, Ninglin Zhao, Chunlei Ge, Cuiling Wu, Ke Li, Li Li, Zhiqiang Wang, Ying Chen, Zhenpu Chen, Weike Li, Yang Liu, Zhonghui Wang, Yun Sha, Hong Yao, Yibo Zhu, Rui Bao   +16 more
doaj   +2 more sources