Results 61 to 70 of about 1,957,946 (299)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Widespread production of plant growth-promoting hormones among marine bacteria and their impacts on the growth of a marine diatom

Microbiome
Background Reciprocal exchanges of metabolites between phytoplankton and bacteria influence the fitness of these microorganisms which ultimately shapes the productivity of marine ecosystems.
Abeeha Khalil, Anna R. Bramucci, Amaranta Focardi, Nine Le Reun, Nathan L. R. Willams, Unnikrishnan Kuzhiumparambil, Jean-Baptiste Raina, Justin R. Seymour   +7 more
doaj   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Clusters

Tidsskrift for Den norske legeforening, 2022
Mette Langaas, Jo Røislien
openaire   +2 more sources

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Exploring fluoropolymers for fabrication of femtoliter chamber arrays used in digital bioanalysis

Scientific Reports
The global supply of fluoropolymers and fluorinated solvents is decreasing due to environmental concerns regarding polyfluoroalkyl substances. CYTOP has been used for decades primarily as a component of a femtoliter chamber array for digital bioanalysis;
Jun Ando, Kazue Murai, Makiko Mori, Tomoe Michiyuki, Tatsuya Iida, Asami Makino, Hajime Shinoda, Rikiya Watanabe   +7 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Self-generation scheme for heteronuclear compound states [PDF]

EPJ Web of Conferences, 2022
Willms S., Bose S., Melchert O., Morgner U., Babushkin I., Demircan A.   +5 more
doaj   +1 more source

Cluster cosmology without cluster finding

Monthly Notices of the Royal Astronomical Society
ABSTRACT We propose that observations of supermassive galaxies contain cosmological statistical constraining power similar to conventional cluster cosmology, and we provide promising indications that the associated systematic errors are comparably easier to control. We consider a fiducial spectroscopic and stellar mass complete sample of
Enia Xhakaj, Alexie Leauthaud, Johannes Lange, Elisabeth Krause, Andrew Hearin, Song Huang, Risa H Wechsler, Sven Heydenreich   +7 more
openaire   +2 more sources