Results 241 to 250 of about 1,732,242 (271)

Are endogenous clustered dna damages induced in human cells?

Free Radical Biology and Medicine, 2004
Although clustered DNA damages are induced in cells by ionizing radiation and can be induced artifactually during DNA isolation, it was not known if they are formed in unirradiated cells by normal oxidative metabolism. Using high-sensitivity methods of quantitative gel electrophoresis, electronic imaging, and number average length analysis, we found ...
Paula V, Bennett, Nela S, Cintron, Laurent, Gros, Jacques, Laval, Betsy M, Sutherland   +4 more
openaire   +2 more sources

Avalanches and Damage Clusters in Fracture Processes

2001
By simulating two-dimensional models of electric breakdown and fracture it is possible to characterize the rupture of disordered materials subject to an increasing external stress. We provide a review of numerical and analytical results concerning the scaling properties of avalanche events prior the macroscopic breakdown of the material.
Stefano Zapperi, Purusattam Ray, H. Eugene Stanley, Alessandro Vespignani   +3 more
openaire   +1 more source

Identifying damage clusters in patients with systemic lupus erythematosus

International Journal of Rheumatic Diseases, 2019
AbstractAimSystemic lupus erythematosus (SLE) causes irreversible damage to organ systems. Recently, evidence has been obtained for subphenotypes of SLE. This study aimed to identify damage clusters and compare the associated clinical manifestations, SLE disease activity, mortality, and genetic risk scores (GRS).MethodsThe study was conducted on the ...
Ga Young Ahn, Jiyoung Lee, Soyoung Won, Eunji Ha, Hyoungyoung Kim, Bora Nam, Ji Soong Kim, Juyeon Kang, Jae‐Hoon Kim, Gwan Gyu Song, Kwangwoo Kim, Sang‐Cheol Bae   +11 more
openaire   +2 more sources

Clustered DNA Damage and its Complexity: Tracking the History

Radiation Research
The concept of radiation-induced clustered damage in DNA has grown over the past several decades to become a topic of considerable interest across the scientific disciplines involved in studies of the biological effects of ionizing radiation. This paper, prepared for the 70th anniversary issue of Radiation Research, traces historical development of the
Dudley T, Goodhead, Michael, Weinfeld
openaire   +2 more sources

Irradiation damage clusters in the oxides of beryllium and magnesium

Journal of Nuclear Materials, 1962
Evidence was obtained for the presence of defect clusters in both BeO and MgO by transmission electron microscopy. Polycrystalline BeO and single crystal MgO were irradiated at 150 deg C to a dose of 3 x 10/sup 19/ nvt. For MgO, heating at 100 deg C intervals in the range 300 to 1200 deg C produced a steady diminution of the damage evidenced by lattice
D.H. Bowen, R.S. Wilks, F.J.P. Clarke
openaire   +1 more source

Characterization of Damage Induced by Cluster Ion Implantation

MRS Proceedings, 2001
ABSTRACTMolecular dynamics simulations of boron monomer and small clusters (B4 and B10) impacting on Si(001) were performed in order to investigate the damage formation by monomer/cluster impact. These monomer and clusters show similar implant depth and efficiency, but different damage structures.
Takaaki Aoki, Jiro Matsuo, Gikan Takaoka
openaire   +1 more source

Damage spreading in the Potts model with cluster dynamics

Physica A: Statistical Mechanics and its Applications, 2000
Abstract We study the Damage Spreading on the two-dimensional ferromagnetic q -state Potts model using Swendsen–Wang dynamics. We find two damage spreading transitions: damage does not spread either at low or high temperatures. At the transition occurring near the Curie temperature our numerical results point through a continuous spreading ...
E.M.de Sousa Luz, M.P Almeida, U.M.S Costa, M.L Lyra   +3 more
openaire   +1 more source

Investigation of Groove Damage Distribution in Proton‐Induced Clustered B‐ DNA Damage

Environmental and Molecular Mutagenesis
ABSTRACT Accurate measurement of DNA damage is critical for therapeutic optimization in proton‐based targeted radiotherapy. This research pioneered the first investigation into the groove damage distribution mechanism in clustered B‐DNA damage induced by proton radiation.
Shanshan Bao, Guang Hu, Chao Wang, Weiqiang Sun, Huasi Hu   +4 more
openaire   +2 more sources

Formation of clustered DNA damage in vivo upon irradiation with ionizing radiation: Visualization and analysis with atomic force microscopy

Proceedings of the National Academy of Sciences of the United States of America, 2022
Ryoichi Hirayama, Toshiaki Nakano, Masataka Tsuda   +2 more
exaly  

Dissecting Highly Mutagenic Processing of Complex Clustered DNA Damage in Yeast Saccharomyces cerevisiae

Cells, 2021
Stanislav Kozmin, Didier Gasparutto, Evelyne Sage   +2 more
exaly