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The interplay between DNA damage response and mitochondrial dysfunction in radiotherapy. [PDF]

Front Oncol
Yang S, Li Y, Zhang J, Shen A, Hu B, Yan J.   +5 more
europepmc   +1 more source

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Radiation Induced Clustered Damage in DNA

Free Radical Research Communications, 1989
(1989). Radiation Induced Clustered Damage in DNA. Free Radical Research Communications: Vol. 6, No. 2-3, pp. 177-178.
U, Hagen, H, Bertram, E M, Geigl, E, Kohfeldt, S, Wendel   +4 more
openaire   +2 more sources

Repair of clustered damage and DNA polymerase iota

Biochemistry (Moscow), 2015
Multiple DNA lesions occurring within one or two turns of the DNA helix known as clustered damage are a source of double-stranded DNA breaks, which represent a serious threat to the cells. Repair of clustered lesions is accomplished in several steps.
E A, Belousova, O I, Lavrik
openaire   +2 more sources

Are endogenous clustered dna damages induced in human cells?

Free Radical Biology and Medicine, 2004
Although clustered DNA damages are induced in cells by ionizing radiation and can be induced artifactually during DNA isolation, it was not known if they are formed in unirradiated cells by normal oxidative metabolism. Using high-sensitivity methods of quantitative gel electrophoresis, electronic imaging, and number average length analysis, we found ...
Paula V, Bennett, Nela S, Cintron, Laurent, Gros, Jacques, Laval, Betsy M, Sutherland   +4 more
openaire   +2 more sources

Oxidatively generated complex DNA damage: Tandem and clustered lesions

Cancer Letters, 2012
There is an increasing interest for oxidatively generated complex lesions that are potentially more detrimental than single oxidized nucleobases. In this survey, the recently available information on the formation and processing of several classes of complex DNA damage formed upon one radical hit including mostly hydroxyl radical and one-electron ...
Cadet, J., Ravanat, J.-L., Taverna Porro, M., Menoni, H., Angelov, D.   +4 more
openaire   +4 more sources

Clustered DNA damage on subcellular level: effect of scavengers

Radiation and Environmental Biophysics, 2014
Clustered DNA damages are induced by ionizing radiation, particularly of high linear energy transfer (LET). Compared to isolated DNA damage sites, their biological effects can be more severe. We investigated a clustered DNA damage induced by high LET radiation (C 290 MeV u(-1) and Fe 500 MeV u(-1)) in pBR322 plasmid DNA.
Kateřina, Pachnerová Brabcová, Lembit, Sihver, Nakahiro, Yasuda, Youichirou, Matuo, Václav, Stěpán, Marie, Davídková   +5 more
openaire   +2 more sources

Clustered DNA Damages Induced by X Rays in Human Cells

Radiation Research, 2002
Although DNA DSBs are known to be important in producing the damaging effects of ionizing radiation in cells, bistranded clustered DNA damages-two or more oxidized bases, abasic sites or strand breaks on opposing DNA strands within a few helical turns-are postulated to be difficult to repair and thus to be critical radiation-induced lesions. Gamma rays
Betsy M, Sutherland, Paula V, Bennett, John C, Sutherland, Jacques, Laval   +3 more
openaire   +2 more sources