Results 241 to 250 of about 2,975,365 (268)

Clustered DNA Damage and its Complexity: Tracking the History

Radiation Research
The concept of radiation-induced clustered damage in DNA has grown over the past several decades to become a topic of considerable interest across the scientific disciplines involved in studies of the biological effects of ionizing radiation. This paper, prepared for the 70th anniversary issue of Radiation Research, traces historical development of the
Dudley T, Goodhead, Michael, Weinfeld
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Oxidatively generated complex DNA damage: Tandem and clustered lesions

Cancer Letters, 2012
There is an increasing interest for oxidatively generated complex lesions that are potentially more detrimental than single oxidized nucleobases. In this survey, the recently available information on the formation and processing of several classes of complex DNA damage formed upon one radical hit including mostly hydroxyl radical and one-electron ...
Cadet, J., Ravanat, J.-L., Taverna Porro, M., Menoni, H., Angelov, D.   +4 more
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Clustered DNA Damages Induced by X Rays in Human Cells

Radiation Research, 2002
Although DNA DSBs are known to be important in producing the damaging effects of ionizing radiation in cells, bistranded clustered DNA damages-two or more oxidized bases, abasic sites or strand breaks on opposing DNA strands within a few helical turns-are postulated to be difficult to repair and thus to be critical radiation-induced lesions. Gamma rays
Betsy M, Sutherland, Paula V, Bennett, John C, Sutherland, Jacques, Laval   +3 more
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A nanodosimetric model of radiation-induced clustered DNA damage yields

Physics in Medicine and Biology, 2010
We present a nanodosimetric model for predicting the yield of double strand breaks (DSBs) and non-DSB clustered damages induced in irradiated DNA. The model uses experimental ionization cluster size distributions measured in a gas model by an ion counting nanodosimeter or, alternatively, distributions simulated by a Monte Carlo track structure code ...
Garty, G., Schulte, R., Shchemelinin, S., Leloup, Corinne, Assaf, G., Breskin, A., Chechik, R., Bashkirov, V., Miligan, J., Grosswendt, B.   +9 more
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Endogenous DNA damage clusters in human hematopoietic stem and progenitor cells

Free Radical Biology and Medicine, 2008
Clustered DNA damages-multiple oxidized bases, abasic sites, or strand breaks within a few helical turns-are potentially mutagenic and lethal alterations induced by ionizing radiation. Endogenous clusters are found at low frequencies in unirradiated normal human cells and tissues. Radiation-sensitive hematopoietic cells with low glycosylase levels (TK6
Paula, Bennett, Alexander A, Ishchenko, Jacques, Laval, Brigitte, Paap, Betsy M, Sutherland   +4 more
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Improvement of the local effect model (LEM)—implications of clustered DNA damage

Radiation Protection Dosimetry, 2006
An improvement of the Local Effect Model (LEM) is presented which takes clustered DNA damage into account. Single strand breaks (SSBs) and double strand breaks (DSBs) are distributed stochastically onto the DNA molecule and additional DSBs are recorded.
Th, Elsässer, M, Scholz
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Investigation of Groove Damage Distribution in Proton‐Induced Clustered B‐ DNA Damage

Environmental and Molecular Mutagenesis
ABSTRACT Accurate measurement of DNA damage is critical for therapeutic optimization in proton‐based targeted radiotherapy. This research pioneered the first investigation into the groove damage distribution mechanism in clustered B‐DNA damage induced by proton radiation.
Shanshan Bao, Guang Hu, Chao Wang, Weiqiang Sun, Huasi Hu   +4 more
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Clustered DNA Damages as Dosemeters for Ionising Radiation Exposure and Biological Responses

Radiation Protection Dosimetry, 2001
Clustered DNA damages--two or more lesions (oxidised bases. abasic sites, or strand breaks) within a few DNA helical turns on opposing strands--are induced in DNA in solution and in vivo in human cells by ionising radiation. They have been postulated to be difficult to repair, and thus of potentially high biological significance.
B M, Sutherland, P V, Bennett, M, Saparbaev, J C, Sutherland, J, Laval   +4 more
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Initial Events in the Cellular Effects of Ionizing Radiations: Clustered Damage in DNA

International Journal of Radiation Biology, 1994
General correlations are found between the detailed spatial and temporal nature of the initial physical features of radiation insult and the likelihood of final biological consequences. These persist despite the chain of physical, chemical and biological processes that eliminate the vast majority of the early damage.
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Dynamics of DNA Double-Strand Breaks Revealed by Clustering of Damaged Chromosome Domains

Science, 2004
Interactions between ends from different DNA double-strand breaks (DSBs) can produce tumorigenic chromosome translocations. Two theories for the juxta-position of DSBs in translocations, the static “contact-first” and the dynamic “breakage-first” theory, differ fundamentally in their requirement for DSB mobility.
Aten, Jacob A., Stap, Jan, Krawczyk, Przemek M., van Oven, Carel H., Hoebe, Ron A., Essers, Jeroen, Kanaar, Roland   +6 more
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