Results 251 to 260 of about 163,016 (283)

A nanodosimetric model of radiation-induced clustered DNA damage yields

Physics in Medicine and Biology, 2010
We present a nanodosimetric model for predicting the yield of double strand breaks (DSBs) and non-DSB clustered damages induced in irradiated DNA. The model uses experimental ionization cluster size distributions measured in a gas model by an ion counting nanodosimeter or, alternatively, distributions simulated by a Monte Carlo track structure code ...
Garty, G., Schulte, R., Shchemelinin, S., Leloup, Corinne, Assaf, G., Breskin, A., Chechik, R., Bashkirov, V., Miligan, J., Grosswendt, B.   +9 more
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Clustered DNA Damage and its Complexity: Tracking the History

Radiation Research
The concept of radiation-induced clustered damage in DNA has grown over the past several decades to become a topic of considerable interest across the scientific disciplines involved in studies of the biological effects of ionizing radiation. This paper, prepared for the 70th anniversary issue of Radiation Research, traces historical development of the
Dudley T, Goodhead, Michael, Weinfeld
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Effect of Hydroxyl Radical Scavenging Capacity on Clustering of DNA Damage

Radiation Research, 1997
We have shown previously that the thiol N-(2'-mercaptoethyl)-1,3-diaminopropane (WR-1065) can attenuate the formation of strand breaks associated with ionizing radiation. The mechanism of this protection is predominantly the reduction of DNA radical species which otherwise would attenuate the chemical repair of DNA radical species which are strand ...
J R, Milligan, J A, Aguilera, C C, Wu, R A, Paglinawan, T T, Nguyen, D, Wu, J F, Ward   +6 more
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Endogenous DNA damage clusters in human hematopoietic stem and progenitor cells

Free Radical Biology and Medicine, 2008
Clustered DNA damages-multiple oxidized bases, abasic sites, or strand breaks within a few helical turns-are potentially mutagenic and lethal alterations induced by ionizing radiation. Endogenous clusters are found at low frequencies in unirradiated normal human cells and tissues. Radiation-sensitive hematopoietic cells with low glycosylase levels (TK6
Paula, Bennett, Alexander A, Ishchenko, Jacques, Laval, Brigitte, Paap, Betsy M, Sutherland   +4 more
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Condensation of DNA—A putative obstruction for repair process in abasic clustered DNA damage

DNA Repair, 2013
Clustered DNA damages are defined as two or more closely located DNA damage lesions that may be present within a few helical turns of the DNA double strand. These damages are potential signatures of ionizing radiation and are often found to be repair resistant. Types of damaged lesions frequently found inside clustered DNA damage sites include oxidized
Vandana, Singh, Prolay, Das
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Simulation of Proton-Induced DNA Damage Patterns Using an Improved Clustering Algorithm

Radiation Research, 2020
Simulations of deoxyribonucleic acid (DNA) molecular damage use the traversal algorithm that has the disadvantages of being time-consuming, slowly converging, and requiring high-performance computer clusters. This work presents an improved version of the algorithm, "density-based spatial clustering of applications with noise" (DBSCAN), using a KD-tree ...
Jing, Tang, Qinfeng, Xiao, Zhiguo, Gui, Baosheng, Li, Pengcheng, Zhang   +4 more
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Fluorescence anisotropy study of radiation-induced DNA damage clustering based on FRET

Analytical and Bioanalytical Chemistry, 2020
A clustered DNA damage site (cluster), in which two or more lesions exist within a few helical turns, is believed to be a key factor determining the fate of a living cell exposed to a DNA damaging agent such as ionizing radiation. However, the structural details of a cluster such as the number of included lesions and their proximity are unknown. Herein,
Ken, Akamatsu, Naoya, Shikazono, Takeshi, Saito   +2 more
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Contribution of indirect effects to clustered damage in DNA irradiated with protons

Radiation Protection Dosimetry, 2015
Protons are the dominant particles both in galactic cosmic rays and in solar particle events and, furthermore, proton irradiation becomes increasingly used in tumour treatment. It is believed that complex DNA damage is the determining factor for the consequent cellular response to radiation. DNA plasmid pBR322 was irradiated at U120-M cyclotron with 30
K, Pachnerová Brabcová, V, Štěpán, M, Karamitros, M, Karabín, P, Dostálek, S, Incerti, M, Davídková, L, Sihver   +7 more
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Improvement of the local effect model (LEM)—implications of clustered DNA damage

Radiation Protection Dosimetry, 2006
An improvement of the Local Effect Model (LEM) is presented which takes clustered DNA damage into account. Single strand breaks (SSBs) and double strand breaks (DSBs) are distributed stochastically onto the DNA molecule and additional DSBs are recorded.
Th, Elsässer, M, Scholz
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Clustered DNA Damage in Irradiated Human Diploid Fibroblasts: Influence of Chromatin Organization

Radiation Research, 2010
Clustered DNA damages are induced by ionizing radiation and are defined as two or more lesions within one or two helical turns. The aim of this study was to investigate the induction and repair of clustered DNA damage in cells with emphasis on the influence of structural differences in the chromatin organization.
Karin, Magnander, Ragnar, Hultborn, Kristina, Claesson, Kecke, Elmroth   +3 more
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