Results 261 to 270 of about 163,016 (283)

Clustered DNA Damages as Dosemeters for Ionising Radiation Exposure and Biological Responses

Radiation Protection Dosimetry, 2001
Clustered DNA damages--two or more lesions (oxidised bases. abasic sites, or strand breaks) within a few DNA helical turns on opposing strands--are induced in DNA in solution and in vivo in human cells by ionising radiation. They have been postulated to be difficult to repair, and thus of potentially high biological significance.
B M, Sutherland, P V, Bennett, M, Saparbaev, J C, Sutherland, J, Laval   +4 more
openaire   +2 more sources

Investigation of Groove Damage Distribution in Proton‐Induced Clustered B‐ DNA Damage

Environmental and Molecular Mutagenesis
ABSTRACT Accurate measurement of DNA damage is critical for therapeutic optimization in proton‐based targeted radiotherapy. This research pioneered the first investigation into the groove damage distribution mechanism in clustered B‐DNA damage induced by proton radiation.
Shanshan Bao, Guang Hu, Chao Wang, Weiqiang Sun, Huasi Hu   +4 more
openaire   +1 more source

Processing of DNA damage clusters in human cells: current status of knowledge

Mol. BioSyst., 2008
Eukaryotic cells exposed to DNA damaging agents activate important defensive pathways by inducing multiple proteins involved in DNA repair, cell cycle checkpoint control and potentially apoptosis. After the acceptance of the hypothesis that oxidatively generated clustered DNA lesions (OCDL: closely spaced DNA lesions) can be induced even by low doses ...
openaire   +2 more sources

Circulating tumor DNA in advanced solid tumors: Clinical relevance and future directions

Ca-A Cancer Journal for Clinicians, 2021
Michael L Cheng, Heather A Parsons, Atish D Choudhury   +2 more
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Production of Clustered DNA Damage by¹²⁵I Decay

Acta Oncologica, 2000
L S, Yasui, A, Hughes, E R, DeSombre
openaire   +2 more sources

DNA damage and repair in age-related inflammation

Nature Reviews Immunology, 2022
Yang Zhao, Andrei Seluanov, Vera Gorbunova   +2 more
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Sources, resolution and physiological relevance of R-loops and RNA–DNA hybrids

Nature Reviews Molecular Cell Biology, 2022
Eva Petermann, Li Lan, Lee Zou
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Nuclear DNA damage signalling to mitochondria in ageing

Nature Reviews Molecular Cell Biology, 2016
Evandro Fei Fang, Morten Scheibye-Knudsen, Vilhelm A Bohr   +2 more
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DNA damage and the balance between survival and death in cancer biology

Nature Reviews Cancer, 2015
Wynand P Roos, Adam D Thomas, Bernd Kaina   +2 more
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The DNA damage response to transcription stress

Nature Reviews Molecular Cell Biology, 2019
Hannes Lans, Jan H J Hoeijmakers, Wim Vermeulen   +2 more
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