Results 91 to 100 of about 134,552 (311)
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Automatic reel controls filler wire in welding machines [PDF]
, 1966 Automatic reel on automatic welding equipment takes up slack in the reel-fed filler wire when welding operation is terminated. The reel maintains constant, adjustable tension on the wire during the welding operation and rewinds the wire from the wire ...
Millett, A. V.
core +1 more source
Allometry of reproduction in broad-snouted caiman (Caiman latirostris)
Brazilian Journal of BiologyIn the present study regression equations are established between broad-snouted caiman (Caiman latirostris) captive reproductive females snout-vent length (SVL) and body mass (BM) and the following clutch characteristics: egg mass, egg "length" (maximal ...
L. M. VERDADE
doaj +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
, 1975 A starting system is described for bringing a large synchronous motor up to speed to prevent large power line disturbances at the moment the motor is connected to the power line.
Daeges, J. J.
core +1 more source
Reproductive behavior and development in Spilotes sulphureus (Serpentes: Colubridae) from Ecuador
Phyllomedusa: Journal of Herpetology, 2018 Reproductive behavior and development in Spilotes sulphureus (Serpentes: Colubridae) from Ecuador. The Birdsnake Spilotes sulphureus is a large-sized species that occurs from the Amazon region to the Atlantic forest of South America.
Jorge H. Valencia, Katty Garzon-Tello
doaj
Overview of molecular signatures of senescence and associated resources: pros and cons
FEBS Open Bio, EarlyView.Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas +6 more
wiley +1 more source
Inherent Problems in Designing Two-Failure Tolerant Electromechanical Actuators [PDF]
, 1984 An electromechanical ac-powered rotary actuated four-bar linkage system for rotating the Shuttle/Centaur deployment adapter is described. The essential features of the deployment adapter rotation system (DARS) are increased reliability for mission ...
Hornyak, S.
core +1 more source
Modeling and simulation study of a novel electromechanical clutch actuation system
Advances in Mechanical Engineering, 2017 A novel motor-driven clutch actuator with force-aided lever has been recently developed. A unique spring is used to assist apply of the clutch that can effectively reduce the motor power requirement, and the actuation system can save power consumption ...
Fengyu Liu +4 more
doaj +1 more source
FEBS Open Bio, EarlyView.The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan +6 more
wiley +1 more source