Results 101 to 110 of about 570,811 (281)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

QCD Physics Potential of CMS [PDF]

, 2009
In view of the approaching LHC operation the feasibility and accuracy of QCD measurements with the CMS experiment at the Large Hadron Collider (LHC) involving hadrons and jets are discussed.
Rabbertz, Klaus
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

A Creative Approach to Isometries Integrating Geogebra and Italc with ‘Paper And Pencil’ Environments

JETEN, 2015
Creativity is recognized nowadays as a basic skill. However, the educational system fails in promoting their development. On the other hand, a growing acknowledgement of the importance of geometry emerges.
Artur Coelho, Isabel Cabrita
doaj  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

75-cm and 22-cm continuum surveys [PDF]

Symposium - International Astronomical Union, 1959
Continuum surveys were made at 75 cm (400 Mc/s) and 22 cm (1390 Mc/s) with the Dwingeloo 25-m telescope.
openaire   +1 more source

The impact of strengthened ward development committees on utilisation of reproductive maternal and child health services in Bayelsa State, Nigeria

BMC Public Health
Introduction Maternal and Child Health (MCH) conditions continue to be a major public health concern in low- and middle-income countries (LMICs), which account for 94% of maternal deaths worldwide.
Chijioke Kaduru, Ganiyat Eshikhena, Eghe Abe, Nwadiuto Ojielo, Neni Aworabhi, Happiness Masa, Uche Ibe, Timiebiere Sabenus, Godwin Idim, Geraldine Mbagwu, Ojonimi Alfred, Paul Abiodun, Pabara Igwele, Abisoye Oyeyemi   +13 more
doaj   +1 more source

International Linear Collider Reference Design Report : Volume 2: Physics at the ICL [PDF]

, 2007
This article reviews the physics case for the ILC. Baseline running at 500 GeV as well as possible upgrades and options are discussed. The opportunities on Standard Model physics, Higgs physics, Supersymmetry and alternative theories beyond the Standard ...
Djouadi, Abdelhak, Lykken, Joseph, Mönig, Klaus, Okada, Yasuhiro, Oreglia, Mark, Phelps, Alan, Yamashita, Satoru   +6 more
core   +1 more source

RPC Gap Production and Performance for CMS RE4 Upgrade

, 2014
CMS experiment constructed the fourth Resistive Plate Chamber (RPC) trigger station composed of 144 RPCs to enhance the high momentum muon trigger efficiency at both endcap regions. All new CMS endcap RPC gaps are produced in accordance with QA and QC at
Kang, Min Ho, Lee, Kyong Sei, Park, Sung Keun   +2 more
core   +1 more source