Results 91 to 100 of about 213,329 (290)

Microprotein MP104 Promotes Malignant Progression of Colorectal Cancer Through Regulating Protein Translation

Advanced Science, EarlyView.
A previously unrecognized microprotein, MP104, encoded by ZEB1‐AS1, emerges as a critical driver of colorectal cancer progression. MP104 links ubiquitin‐mediated protein degradation with translational reprogramming via the UBE2O–AMPKα2–mTOR–EIF4B axis, revealing an unrecognized layer of oncogenic regulation.
Fang Chen, Miao Wang, Hongmei Yong, Jin Ding, Shiping Xu, Qirui Ge, Yan Wang, Lei Zhang, Qianqian Xiao, Benli Li, Li Lin, Sufang Chu, Qianqing Wang, Jin Bai, Pingfu Hou   +14 more
wiley   +1 more source

Assay of TORCH profile in patients with congenital cataract aged 0-4 years at a tertiary eye hospital

Kerala Journal of Ophthalmology
Purpose: To evaluate the TORCH profile (Toxoplasma gondii, rubella, cytomegalovirus, and herpes simplex virus1 and 2) of all patients with congenital cataract excluding traumatic cataracts aged 0-4 yrs over a period 12 months at a tertiary eye hospital ...
K Tejaswi, Y. Raman, A. Krishna Kishore, Darakshan Qureshi   +3 more
doaj   +1 more source

IMMUNOMODULATORS IN OPPORTUNISTIC INFECTIONS TREATMENT

Инфекция и иммунитет, 2014
. The immune status and the level of specific antibodies to Cytomegalovirus (121 patients) or Mycoplasma pneumoniae (129 patients) were tested in 250 patients aged 19–56 years old. This cohort was divided for three groups. Seventy eight patients with low
A. P. Toptygina, G. V. Bobyleva, V. A. Alioshkin   +2 more
doaj   +1 more source

Structural Polymorphism of polyG Inclusions Revealed by In Situ Cryo‐Electron Tomography

Advanced Science, EarlyView.
Correlative cryo‐electron tomography in primary cortical neurons and NIID mouse brain tissue reveals that polyG inclusions are interconnected ribbon‐like assemblies rather than canonical amyloid fibrils. Multiple compartment‐specific ribbon states show distinct 26S proteasome accessibility, while cytoplasmic ribbons contact and deform ER‐like ...
Yunwen Qian, Yalan Wan, Chen Chen, Xiaoyu Zheng, Wenjing Du, Junhan Yang, Zhihao Quan, Biyu Yang, Jiaxi Yu, Jie Zheng, Zhaoxia Wang, Jianwen Deng, Qiang Guo   +12 more
wiley   +1 more source

Human herpesviruses in the pathogenesis of orbit and eye tumors: detection of herpesvirus DNA in tumor biopsies

Российский офтальмологический журнал, 2018
Biopsy samples of 32 patients with uveal melanoma (10), RBL (11), orbital lymphoma (7), lacrimal gland adenomas (2), rhabdomyosarcoma of conjunctiva (2) were tested by real time polymerase chain reaction (PCR) to detect the DNA of HSV 1, HSV 2, EBV, CMV,
A. E. Andryushin, I. P. Khoroshilova, G. P. Zakharova, A. M. Maybogin, A. V. Trukhina, A. E. Andryushin, I. P. Khoroshilova, G. P. Zakharova, A. M. Maybogin, A. V. Trukhina   +9 more
doaj   +1 more source

An email survey of midwives knowledge about CytoMegaloVirus (CMV) in Hannover and a skeletal framework for a proposed teaching program [PDF]

, 2012
At present there is lack of information about CMV transmission given to midwives, general practitioners, neonatal pediatricians and nurses, with intrauterine transmission having profound consequences in terms of outcomes for the infected neonate.
Hollins Martin, Caroline J, Hollins-Martin, CJ, Gartzen von, Aleyd, von Gartzen, A   +3 more
core   +1 more source

Engineering a 660 nm‐Responsive Optogenetic Inducer of Pyroptosis for Precision Cancer Therapy

Advanced Science, EarlyView.
This study reports a bioorthogonal pyroptosis inducer, PyroRACS. By using a red‐light‐responsive Cre‐On genetic switch to control the expression of highly cytotoxic GSDMDNT, PyroRACS enables the artificial induction of pyroptosis with precise spatiotemporal control.
Mengkai Zhang, Zhichao Li, Yonghao Ma, Yangyang Sun, Wei Chen, Weiren Huang   +5 more
wiley   +1 more source

Identification and subgrouping of cucumber mosaic virus isolate infecting New Guinea impatiens (Impatiens hawkeri) in Serbia [PDF]

Journal of Central European Agriculture
New Guinea impatiens (Impatiens hawkeri) is a species of flowering plant in the family Balsaminaceae that is popular as a bedding and pot plant. In May 2020, impatiens plants showing chlorotic and necrotic concentric rings, mosaic, leaf malformation and ...
Katarina Zečević, Ivana Stanković, Branka Krstić   +2 more
doaj   +1 more source

The Immunology of Posttransplant CMV Infection [PDF]

Transplantation, 2016
The immune response to cytomegalovirus (CMV) infection is highly complex, including humoral, cellular, innate, and adaptive immune responses. Detection of CMV by the innate immune system triggers production of type I IFNs and inflammatory cytokines which initiate cellular and humoral responses that are critical during the early viremic phase of CMV ...
openaire   +3 more sources

Shedding light on the elusive role of endothelial cells in cytomegalovirus dissemination. [PDF]

, 2011
Cytomegalovirus (CMV) is frequently transmitted by solid organ transplantation and is associated with graft failure. By forming the boundary between circulation and organ parenchyma, endothelial cells (EC) are suited for bidirectional virus spread from ...
Jauch, Karl-Walter, Sacher, Torsten, Lars Dölken, Aivars Kalnins, Matthias J Reddehase, Ulrich H Koszinowski, Koszinowski, Ulrich H., Zsolt Ruzsics, Podlech, Jürgen, Karl-Walter Jauch, Ruzsics, Zsolt, Andrassy, Joachim, Dölken, Lars, Joachim Andrassy, Matthias J. Reddehase, Jordan, Stefan, Ulrich H. Koszinowski, Reddehase, Matthias J., Stefan Jordan, Kalnins, Aivars, Torsten Sacher, Jürgen Podlech   +21 more
core   +2 more sources