Results 71 to 80 of about 213,329 (290)

Penfluridol Triggers GSDME‐Mediated Immunogenic Pyroptosis to Potentiate Antitumor Immunotherapy

Advanced Science, EarlyView.
A high‐throughput screen of FDA‐approved antipsychotics identifies penfluridol as a potent pyroptosis inducer acting via direct TTI1 inhibition. This triggers TNFA‐NFKB signaling and caspase‐8/‐3‐dependent GSDME cleavage. The compound stimulates antitumor immunity alone and synergizes with anti‐PD‐1 therapy, while low TTI1 expression emerges as a ...
Linfeng Li, Daishi Li, Danyao Chen, Yating Dian, Lei Yao, Hui Su, Ziyu Guo, Deze Zhao, Zihua Wu, Furong Zeng, Chunfang Zhang, Guangtong Deng   +11 more
wiley   +1 more source

Cytomegalovirus Duodenitis in a Renal Transplant Patient Presenting with Signs of Gastrointestinal Bleeding: A Case Report

Haseki Tıp Bülteni, 2020
Cytomegalovirus (CMV) is a common virus that causes opportunistic infections in many organ systems in immunocompromised patients. CMV infections are also an important problem in renal transplant patients.
Atilla Bulur, Uğuray Payam Hacısalihoğlu, Özgür Merhametsiz, Mehmet Emin Demir   +3 more
doaj   +1 more source

Liver Endothelia Orchestrate MASH‐Associated Macrophage Zonation Through FSTL1‐ITGA4 Axis

Advanced Science, EarlyView.
Liver inflammation in MASH fundamentally hinges on the newly defined Kit/STAT2/FSTL1/ITGA4 axis. Declining endothelial Kit collapses normal hepatic zonation, driving an aberrant FSTL1 gradient that recruits pathogenic macrophages. Strikingly, targeting FSTL1‐ITGA4 with anti‐VLA4 restores spatial immune homeostasis and halts disease progression ...
Lin Sun, Zhensheng Yue, Zhiqiang Fang, Hao Xu, Wei Du, Yuwei Ling, Jingjing Liu, Ping Song, Fei He, Juanli Duan, Lin Wang   +10 more
wiley   +1 more source

CD107a Expression and IFN-γ Production as Markers for Evaluation of Cytotoxic CD3+ CD8+ T Cell Response to CMV Antigen in Women with Recurrent Spontaneous Abortion [PDF]

International Journal of Fertility and Sterility, 2014
Background: Some evidence has shown a relationship between primary human cytomegalovirus (CMV) infection and pregnancy loss. The impact of CMV infection reactivation during pregnancy on adverse pregnancy outcomes is not completely understood.
Batoul Tarokhian, Roya Sherkat, Mohamma Hossein Nasr Esfahani, Minoo Adib, Abbas Kiani Esfahani, Behrooz Ataei   +5 more
doaj  

CMV-IgM and -IgG serostatus of viremic and aviremic patients.

, 2017
CMV-IgM and -IgG serostatus of viremic and aviremic patients.
Lutz Renders (3701038), Michael Neuenhahn (168944), Dirk H. Busch (125319), Dieter Hoffmann (347734), Volker Hösel (3701041), Jens Lutz (3701035), Uwe Heemann (285995), Fabian Schlott (414947), Dominik Steubl (3159330), Edouard Matevossian (287579)   +9 more
core   +1 more source

A Generative Neuro‐Symbolic AI for Protein Sequence Design

Advanced Science, EarlyView.
We introduce EffieDes, a neuro‐symbolic framework coupling deep learning‐based fitness landscape parameterization with exact automated reasoning. Unlike greedy sampling, EffieDes identifies sequences that globally optimize fitness while satisfying intricate design constraints.
Marianne Defresne, Delphine Dessaux, Samuel Buchet, Lucie Barthe, Liza Ammar‐Khodja, Bessam Azizi, Valentin Durante, Gianluca Cioci, Simon de Givry, Alain Roussel, Luis F. Garcia‐Alles, Thomas Schiex, Sophie Barbe   +12 more
wiley   +1 more source

RPLP2 Mediates the Beneficial Effects of Exercise on Stress Resistance Through Muscle–Brain Communication

Advanced Science, EarlyView.
A novel exercise‐inducible myokine acidic ribosomal protein P2 (RPLP2), initially identified from human trials, is presented here, whose circulating levels negatively correlate with clinical anxiety severity. Muscle‐derived RPLP2 enhances hippocampal ribosomal assembly and adult neurogenesis to rescue stress‐induced anxiety deficits.
Peiyu Luo, Wei Wu, Huan Peng, Dan He, Yuxi Guo, Boyue Zhao, Xiaodan Wang, Li Ma, Yuhang Qin, Yifang Zhai, Lixia Zhuo, Ying Zhang, Yijie Guo, Linlin Jing, Fangyao Chen, Erfei Zhang, Wei Wang, Xiancang Ma, Yan Li   +18 more
wiley   +1 more source

CMV-L1-neo^RT induces γH2AX in MxB knockout cells.

, 2022
(A) Western blot to detect γH2AX in the control or MxB knockout HeLa cells which were transfected with CMV-L1-neoRT plasmid. (B, C) Detection of γH2AX foci in the control and MxB knockout cells transfected with CMV-L1-neoRT plasmid.
Zhangling Fan (12095869), Shan Mei (351116), Liming Wang (114648), Fei Guo (181055), Bin Ai (1842637), Chen Liang (196452), Yu Huang (15093), Liang Wei (216043), Yamei Hu (10321437), Xiaoman Liu (109881), Fengwen Xu (764677), Fei Zhao (183673), Shan Cen (107285)   +12 more
core   +1 more source

HMGCR‐Driven Cholesterol Metabolism Promotes Osteoarthritis Progression by Accelerating Synovial Fibroblast Senescence

Advanced Science, EarlyView.
In the pathological context of osteoarthritis (OA), the phosphorylation of AKT1 at Ser473 enhances its binding to Lys140 of Insig1, which facilitates the formation of AKT1–Insig1 complex. Subsequently, the activation of AKT1 promotes the phosphorylation of Insig1 at Ser189, potentially enhancing the dissociation of Insig1 from sterol regulatory element‑
Xiaoqi Zhang, Siru Zhou, Xi Liu, Wei Xiang, Xiuqin Peng, Yu Tian, Song Li, Hailin Wang, Bo Liao, Shunzheng Fang, Runze Jin, Jinhui Wu, Chuanqing Bai, Wei Zhang, Bo Huang, Bingfei Li, Lifeng Chen, Lin Chen, Bin Zhang, Zhenhong Ni   +19 more
wiley   +1 more source

Utility of Reflex CMV Immunohistochemistry in Patients with Inflammatory Bowel Disease [PDF]

Türk Patoloji Dergisi
Objective: We aimed to investigate the association between CMV immunohistochemistry positivity and clinical, endoscopic, histologic, and tissue CMV PCR findings in ileocolonoscopic biopsies of inflammatory bowel disease patients, and to assess the ...
Melek BUYUK, Neslihan BERKER, Dogu VURALLI BAKKALOGLU, Elif EROGLU, Sevim MESE, Bilger CAVUS, Aslı CIFCIBASI ORMECI, Mustafa ONEL, Ali AGACFIDAN, Mine GULLUOGLU   +9 more
doaj   +1 more source