Results 71 to 80 of about 172,015 (263)

Assay of TORCH profile in patients with congenital cataract aged 0-4 years at a tertiary eye hospital

Kerala Journal of Ophthalmology
Purpose: To evaluate the TORCH profile (Toxoplasma gondii, rubella, cytomegalovirus, and herpes simplex virus1 and 2) of all patients with congenital cataract excluding traumatic cataracts aged 0-4 yrs over a period 12 months at a tertiary eye hospital ...
K Tejaswi, Y. Raman, A. Krishna Kishore, Darakshan Qureshi   +3 more
doaj   +1 more source

IMMUNOMODULATORS IN OPPORTUNISTIC INFECTIONS TREATMENT

Инфекция и иммунитет, 2014
. The immune status and the level of specific antibodies to Cytomegalovirus (121 patients) or Mycoplasma pneumoniae (129 patients) were tested in 250 patients aged 19–56 years old. This cohort was divided for three groups. Seventy eight patients with low
A. P. Toptygina, G. V. Bobyleva, V. A. Alioshkin   +2 more
doaj   +1 more source

OAF Blocks SIAH1‐Mediated Degradation of SCPX, a Therapeutic Strategy for MASLD

Advanced Science, EarlyView.
This study shows OAF directly binds to SCPX and inhibits its interaction with the E3 ligase SIAH1, thereby protecting SCPX from ubiquitin‐dependent degradation and stabilizing its levels. This OAF‐SCPX axis represents a novel pathway in lipid homeostasis, highlighting OAF as a promising therapeutic candidate for MASLD.
Zongxi Li, Jingyue Song, Kaili Ma, Shunan Tang, Shuqian Wang, Wenya Ji, Chen Lu, Ting Zhang, Huaping Zheng, Xiaowei Zheng, Shanshan Lai, Cheng Deng   +11 more
wiley   +1 more source

Human herpesviruses in the pathogenesis of orbit and eye tumors: detection of herpesvirus DNA in tumor biopsies

Российский офтальмологический журнал, 2018
Biopsy samples of 32 patients with uveal melanoma (10), RBL (11), orbital lymphoma (7), lacrimal gland adenomas (2), rhabdomyosarcoma of conjunctiva (2) were tested by real time polymerase chain reaction (PCR) to detect the DNA of HSV 1, HSV 2, EBV, CMV,
A. E. Andryushin, I. P. Khoroshilova, G. P. Zakharova, A. M. Maybogin, A. V. Trukhina, A. E. Andryushin, I. P. Khoroshilova, G. P. Zakharova, A. M. Maybogin, A. V. Trukhina   +9 more
doaj   +1 more source

The Immunology of Posttransplant CMV Infection [PDF]

Transplantation, 2016
The immune response to cytomegalovirus (CMV) infection is highly complex, including humoral, cellular, innate, and adaptive immune responses. Detection of CMV by the innate immune system triggers production of type I IFNs and inflammatory cytokines which initiate cellular and humoral responses that are critical during the early viremic phase of CMV ...
openaire   +3 more sources

Multi‐Technique Integration Identifies O‐GlcNAc Transferase in Fibroblast‐Like Synoviocytes as a Therapeutic Target for Rheumatoid Arthritis

Advanced Science, EarlyView.
AI‑guided single‑cell transcriptomics identifies OGT as a key regulator enriched in rheumatoid arthritis fibroblast‑like synoviocytes (RA‐FLSs). Inflammatory stimuli activate the OGT–SAP130 axis, which modulates the H3K27ac/H3K27me3 balance and epigenetically silences BTG2, promoting aggressive transformation of RA‑FLSs.
Duoli Xie, Jie Huang, Chunhao Cao, Zhenchao Tang, Xingchen Li, Jianmin Guo, Xinxin Chen, Fang Wang, Dongyi He, Jie Li, Yu Du, Bing He, Jianhua Yao, Aiping Lu, Chao Liang   +14 more
wiley   +1 more source

Identification and subgrouping of cucumber mosaic virus isolate infecting New Guinea impatiens (Impatiens hawkeri) in Serbia [PDF]

Journal of Central European Agriculture
New Guinea impatiens (Impatiens hawkeri) is a species of flowering plant in the family Balsaminaceae that is popular as a bedding and pot plant. In May 2020, impatiens plants showing chlorotic and necrotic concentric rings, mosaic, leaf malformation and ...
Katarina Zečević, Ivana Stanković, Branka Krstić   +2 more
doaj   +1 more source

CMV seroconversion in pregnants and the incidence of congenital CMV infection.

The Turkish journal of pediatrics, 2007
In this study, it was aimed to determine the ratio of CMV seroconversion in pregnant women, the prevalence of maternal CMV infection and also the incidence of congenital CMV infection in their newborns in the Antalya region of Turkey. During a one-year period, CMV-specific IgG and IgM were determined in all (n: 1027) pregnant women admitted at 8 to 20 ...
Ali Satilmiş, Aşkin Güra, Hakan Ongun, Inanç Mendilcioğlu, Dilek Colak, Nihal Oygür   +5 more
openaire   +2 more sources

AARS1‐Mediated H3K27 Lactylation Rewires Glycolysis to Sustain Aggressive and Recurrent Bladder Cancer

Advanced Science, EarlyView.
AARS1 drives PI3K–AKT–mTOR‐dependent glycolysis in bladder cancer, promoting lactate accumulation, increased lactylation, H3K27la enrichment at the HK2 promoter, and HK2 transcription. HK2 reinforces glycolysis, sustaining a metabolic–epigenetic program associated with tumor progression, recurrence, and metastasis.
Qin Yuan, Tianbao Song, Yipeng He, Sihan Xia, Yaoqiu Huang, Wenlin He, Qin Yi, Zefeng Wang, Peihan Wang, Chenbo Huang, Linzhi Li, Zhen Yin, Fan Cheng, Weimin Yu   +13 more
wiley   +1 more source

Spatiotemporal Multi‐Omic Mapping Reveals Liver‐Muscle Metabolic Crosstalk in Cancer Cachexia

Advanced Science, EarlyView.
The interactive CCAtlas platform delineates cross‐species, spatiotemporal, and sex‐specific molecular dynamics and metabolic rewiring across organs during cancer cachexia. Hepatic Gamt downregulation curtails hepatic creatine synthesis to trigger systemic creatine insufficiency and consequent skeletal muscle atrophy in LLC tumour‐bearing mice ...
Zihan Tian, Qianyu Wang, Wenyan Gao, Xianfeng Li, Jiawen Fan, Xiaoliang Wu, Siqi Liu, Xiangdong Ming, Danna Yeerken, Mutian Shen, Qingjie Min, Qimin Zhan, Yan Wang   +12 more
wiley   +1 more source