Results 61 to 70 of about 213,329 (290)

Loss of E3 Ubiquitin Ligase RINES via CpG Methylation Relieves Suppression of STAT3 and MYC, Facilitating Multiple Tumorigeneses

Advanced Science, EarlyView.
Dysregulated protein modifications drive tumorigenesis. RINES, an E3 ubiquitin ligase, represses tumor cell proliferation and metastasis by facilitating RING domain‐dependent, ubiquitin–proteasome‐mediated degradation of STAT3 and MYC, which consequently restrains cancer stemness and oncogenic progression.
Lili Li, Ka Man Ng, Xingsheng Shu, Xiaoxue Chai, Kai Yau Wong, Gopesh Srivastava, Anthony T.C. Chan, Wai Yee Chan, Qian Tao   +8 more
wiley   +1 more source

Review of Antiviral Effects of Glycyrrhiza glabra L. and Its Active Component, Glycyrrhizin

Journal of Medicinal Plants, 2007
Background: Licorice (Glycyrrhiza sp.) belongs to family of Leguminosae. A number of components have been isolated from licorice, including triterpene saponins, flavonoids, isoflavonoides, chalcones and various other substances.
M Nassiri Asl, H Hosseinzadeh
doaj  

CMV-antibody titers and variations in CMV-antibody titers in kidney transplant patients.

, 2018
CMV antibody titers were quantified by ELISA in the sera of patients prior to transplantation and at the end of follow-up. (A) Comparisons of CMV antibody titers at transplantation and at the end of follow-up in WVR (n = 16), VR (n = 26) and VI (n = 7 ...
Rebeca Alonso-Arias (5089019), Alejandra García-Torre (5089028), María Luisa Suárez-Fernández (5089022), Pablo Martínez-Camblor (295223), Marco Antonio Moro-García (5089013), Minerva Rodríguez (5089010), Marta Elena Álvarez-Argüelles (276222), María Iglesias-Escudero (5089016), Raquel Marcos-Fernández (5089025)   +8 more
core   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Single‐Cell RNA Editing Identifies T Cell ADAR1 as a Key Regulator of Immune Exhaustion and Anti‐PD‐1 Resistance in Colorectal Cancer

Advanced Science, EarlyView.
Single‐cell RNA editing analysis identifies ADAR1 as a regulator of dysfunctional T cell states in colorectal cancer. Elevated ADAR1 activity promotes T cell exhaustion and impairs antitumor immunity partly through TGF‐β‐SMAD signaling, contributing to anti‐PD‐1 resistance and highlighting T cell ADAR1 as a potential therapeutic target and biomarker ...
Da Kang, Song‐Zuo Xie, Yong‐Zhou Luo, Xin‐Pei Deng, Xi‐Rong Tan, Ze‐Geng Chen, Ling‐Xing Zeng, Gong Chen, Pei‐Rong Ding, Zhi‐Zhong Pan, Rong‐Xin Zhang   +10 more
wiley   +1 more source

THE SOCIO-MEDICAL CHARACTERISTICS OF WOMEN WITH THREATENED PRETERM LABOR

Акушерство, гинекология и репродукция, 2016
Objective: to investigate health and social factors leading to the emergence of threatening preterm birth.Material and methods: This study was designed to evaluate the significance of social conditions, professional and material factors, obstetric and ...
A. I. Malyshkina, A. O. Nazarova, A. A. Kozyrina, Yu. N. Zholobov, S. B. Nazarov   +4 more
doaj   +1 more source

Human Cytomegalovirus (HCMV) Reactivation in the Mammary Gland Induces a Proinflammatory Cytokine Shift in Breast Milk

Microorganisms, 2020
A locally restricted human cytomegalovirus (HCMV) reactivation in the mammary gland commonly occurs in nearly every IgG-seropositive breastfeeding mother.
Tabea Rabe, Katrin Lazar, Christoffer Cambronero, Rangmar Goelz, Klaus Hamprecht   +4 more
doaj   +1 more source

MAM‐Localized MANF Counteracts Microinflammatory Stress to Attenuate Mitochondrial Dysfunction and Cataractogenesis in High Myopia

Advanced Science, EarlyView.
Chronic microinflammation in high myopia suppresses MANF in lens epithelial cells. MANF normally resides within MAMs and promotes ubiquitin‐mediated degradation of the ER Ca2+ pump SERCA2. MANF loss causes pathological SERCA2 accumulation, MAM hyperassembly, and disrupted ER‐to‐mitochondria Ca2+ transfer, leading to mitochondrial failure, oxidative ...
Xin Liu, Hao Li, Ching Kang, Dongling Guo, Shuyu Liu, Jiaqi Meng, Zhiqian Huang, Yu Du, Xiangjia Zhu   +8 more
wiley   +1 more source

Targeting NSUN2‐Mediated m5C Modification Attenuates Chondrocyte Senescence and NLRP3 Activation in Osteoarthritis

Advanced Science, EarlyView.
NSUN2‐mediated m5C modification cooperates with ALYREF to stabilize and export IP3R3 mRNA, increasing IP3R3 expression and Ca2 + overload in chondrocytes. This signaling promotes mitochondrial dysfunction, NLRP3 inflammasome activation, and senescence, thereby accelerating osteoarthritis progression.
Guping Mao, Wei Li, Zhencan Lin, Zengfa Deng, Ming Li, Zongrui Jiang, Changzhao Li, Dianbo Long, Yan Kang   +8 more
wiley   +1 more source

External quality assessment of CMV-DNA detection on dried blood spots

, 2007
Testing for viral DNA in neonatal blood dried on paper (DBS) has proved a valid means of diagnosing congenital CMV infection with both clinical and epidemiological relevance.
S. Binda, W. MacKay, A. van Loon, M. Barbi   +3 more
core   +2 more sources