Results 51 to 60 of about 213,329 (290)

Genetically Programmed Shape‐Morphing of Engineered Living Materials

Advanced Functional Materials, EarlyView.
Here, bacterial and mammalian engineered living materials (ELMs) are presented, in which living cells direct genetically programmed and enzymatically mediated shape‐morphing. The resulting deformation and shape‐recovery can be actuated in a genetically controlled manner by an ELM incorporating out‐of‐equilibrium counteracting biochemical reactions with
Jan Becker, Yuchen Liu, Miguel Baños, Rosanne Schmachtenberg, Mahmudul Hasan, Claudia Fink‐Straube, Luai R. Khoury, Wilfried Weber   +7 more
wiley   +1 more source

Düşük Doz Steroid Tedavisi Sonrası Gelişen CMV Reaktivasyonu

Atatürk Üniversitesi Tıp Fakültesi Cerrahi Tıp Bilimleri Dergisi
Cytomegalovirus (CMV) insandan insana bulaşan ve ömür boyu latent kalabilen bir virüstür. Primerenfeksiyonu daha sıklıkla gribal şikâyetlerle çocukluk döneminde karşımıza çıkmaktayken vücuttalatent kalarak özellikle immunsupresan durumlarda reaktivasyon ...
Ayse Albayrak, Kemalettin Özden, Handan Alay, Fatma Kesmez Can, Kübra Gögebakan   +4 more
doaj   +1 more source

Engineered Microvascular Model of the Blood–Brain–Tumor Barrier Reveals Endothelial Remodeling in Diffuse Midline Glioma

Advanced Healthcare Materials, EarlyView.
We developed a patient‐derived, functional microfluidic model of the diffuse midline glioma (DMG) blood–brain–tumor barrier (BBTB) comprised of endothelial cells, astrocytes, pericytes, and tumor cells. The system forms perfusable microvasculature, reveals the BBTB retains vascular integrity, identifies DMG‐specific transcriptomic changes distinct from
Kimberly R. Bennett, Yann S. Vanrobaeys, Tessy Teboh, Zakiya Smith, Anderson Scott, Cynthia Hajal, Paula T. Hammond, Joelle P. Straehla   +7 more
wiley   +1 more source

CMV-infection in gay men with AIDS

, 2017
Background: Before the era of combination therapy (c-ART) more than 90 % of the patients with HIV-infection died of one or more opportunistic infections (OI). We and others noted early on that CMV was an important pathogen in these patients.
Sven Grützmeier (18665626)
core   +1 more source

Multisystem cytomegalovirus end-organ disease in a patient with advanced HIV

Southern African Journal of Infectious Diseases, 2022
Cytomegalovirus (CMV) infection is common in people living with HIV, but multisystem CMV end-organ disease (EOD) is rare following the introduction of effective antiretroviral therapy.
Ruan Spies, Pierre Joubert, Dharshnee Chetty, Sipho Dlamini, Muhammed S. Moosa   +4 more
doaj   +1 more source

Spatial Control of Light‐Responsive Proteins and Optogenetics Within Hydrogels via Volumetric Bioprinting

Advanced Materials, EarlyView.
Spatiotemporal control over cell behavior within bioprinted constructs remains a key challenge in biofabrication. Volumetric bioprinting using multi‐wavelength light sources permits to activate light‐sensitive intracellular proteins as well as optogenetic gene and protein expression circuits in bioprinted cells, in addition to enabling fast printing of
Davide Ribezzi, Pere Català, Gabriel Größbacher, Paulina Nuñez Bernal, Olaf Nijssen, Sammy Florczak, Wilco Nijenhuis, Nuria Crusellas‐Villorbina, Bram Nijhoff, Paul Delrot, Jos Malda, Andreas Hierholzer, Martin Fussenegger, Lukas C. Kapitein, Riccardo Levato   +14 more
wiley   +1 more source

SYMPTOMS VARIATION OF VIRAL INFECTIONS IN YARDLONG BEAN

Jurnal Hama dan Penyakit Tumbuhan Tropika, 2020
Yardlong bean (Vigna unguiculata subsp. sesquipedalis L.) is an important horticultural commodity in Indonesia. During the last ten years, yardlong bean planting areas in Indonesia especially in Java often suffered from epidemics of viral disease showing
Supyani ., Dwiwiyati Nurul Septariani, Hadiwiyono .   +2 more
doaj   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV

Advanced Science, EarlyView.
Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes, Gabriela Silva, Mafalda Aleixo, Marta Gomes, Daniel Simão, Stephan J. Holtkamp, Diana D. Lobo, Pradeep Harish, Rosalind Jenkins, Lekh N. Dahal, Rui J. Nobre, Luís de Pereira de Almeida, Mark Trautwein, Paula M. Alves, Catarina Brito   +14 more
wiley   +1 more source

CMV-associated disruption of polarized HCoEpiC monolayer integrity is partially attributed to CMV-induced IL-6.

, 2017
Polarized HCoEpiC derived from two donors (#1 and #2) were inoculated with CMV VR1814 at a MOI of 1.0; TER was measured 9 days after inoculation by Millicell-ERS (A), and culture medium was collected for quantification of TNF-α (Β), IL-6 (C), and IL-1β ...
Ma Somsouk (283498), Ekaterina Maidji (3797899), Cheryl A. Stoddart (77030), Peter W. Hunt (231174), Jose M. Rivera (3797902)   +4 more
core   +1 more source