Results 121 to 130 of about 89,184 (144)
Αποτίμηση της δράσης των απαδενυλασών PARN, CNOT6, CNOT6-LIKE, CNOT7 και CNOT8 στη σταθερότητα RNAs
, 2017 openaire +1 more source
Essential functions of the CNOT7/8 catalytic subunits of the CCR4-NOT complex in mRNA regulation and cell viability [PDF]
RNA Biology, 2020 Shortening of mRNA poly(A) tails (deadenylation) to trigger their decay is mediated mainly by the CCR4-NOT deadenylase complex. While four catalytic subunits (CNOT6, 6L 7, and 8) have been identified in the mammalian CCR4-NOT complex, their individual biological roles are not fully understood.
Takaya Abe, Keiji Kuba, Akiko Yanagiya
exaly +9 more sources
DEAD-box helicase eIF4A2 inhibits CNOT7 deadenylation activity [PDF]
Nucleic Acids Research, 2019 Abstract The CCR4–NOT complex plays an important role in the translational repression and deadenylation of mRNAs. However, little is known about the specific roles of interacting factors. We demonstrate that the DEAD-box helicases eIF4A2 and DDX6 interact directly with the MA3 and MIF domains of CNOT1 and compete for binding. Furthermore,
Hedda Meijer +2 more
exaly +6 more sources
hCAF1/CNOT7 regulates interferon signalling by targeting STAT1 [PDF]
EMBO Journal, 2013 Stringent regulation of the interferon (IFN) signalling pathway is essential for maintaining the immune response to pathogens and tumours. The transcription factor STAT1 is a crucial mediator of this response. Here, we show that hCAF1/CNOT7 regulates class I and II IFN pathways at different crucial steps.
Pierre de la Grange +2 more
exaly +5 more sources
CNOT7 Outcompetes Its Paralog CNOT8 for Integration into The CCR4-NOT Complex
Journal of Molecular Biology, 2022 The CCR4-NOT deadenylase complex is a major post-transcriptional regulator of eukaryotic gene expression. CNOT7 and CNOT8 are both vertebrate homologs of the yeast CCR4-NOT catalytic subunit Caf1. They are highly similar and are sometimes considered redundant, but Cnot7 and Cnot8 knockout mice exhibit different phenotypes, implying distinct ...
Akiko Yanagiya +2 more
exaly +3 more sources
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CNOT7 modulates biological functions of ovarian cancer cells via AKT signaling pathway
Life Sciences, 2021CNOT7 plays an important role in many biological processes, providing attractive opportunities for the treatment of malignant tumors. However, the functions and mechanism of CNOT7 in ovarian cancer (OC) have not been elucidated. The purpose of this study was to assess the role of CNOT7 in OC.SKOV3 and A2780 cells were chosen as the cell lines for the ...
Haiyan Zhu, Jiangtao Yu
exaly +3 more sources
Cnot7-Null Mice Exhibit High Bone Mass Phenotype and Modulation of BMP Actions†
Journal of Bone and Mineral Research, 2007 Abstract Cnot7 is a recently identified regulator of spermatogenesis in adult mice. Because Cnot7 binds to Tob, a BMP inhibitor shown to be involved in bone metabolism, we examined whether Cnot7 is involved in bone mass regulation by using adult Cnot7 deficient mice. Cnot7−/− mice exhibited a high bone mass phenotype.
Michihiko Usui +2 more
exaly +3 more sources