Results 131 to 140 of about 86,437 (152)
Essential functions of the CNOT7/8 catalytic subunits of the CCR4-NOT complex in mRNA regulation and cell viability [PDF]
RNA Biology, 2020 Shortening of mRNA poly(A) tails (deadenylation) to trigger their decay is mediated mainly by the CCR4-NOT deadenylase complex. While four catalytic subunits (CNOT6, 6L 7, and 8) have been identified in the mammalian CCR4-NOT complex, their individual biological roles are not fully understood.
Dina Mostafa +2 more
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DEAD-box helicase eIF4A2 inhibits CNOT7 deadenylation activity [PDF]
Nucleic Acids Research, 2019 Abstract The CCR4–NOT complex plays an important role in the translational repression and deadenylation of mRNAs. However, little is known about the specific roles of interacting factors. We demonstrate that the DEAD-box helicases eIF4A2 and DDX6 interact directly with the MA3 and MIF domains of CNOT1 and compete for binding. Furthermore,
Hedda A Meijer +2 more
exaly +7 more sources
The Ccr4–Not Deadenylase Subunits CNOT7 and CNOT8 Have Overlapping Roles and Modulate Cell Proliferation [PDF]
Molecular Biology of the Cell, 2009 Accurate gene expression requires the precise control of mRNA levels, which are determined by the relative rates of nuclear (pre-)mRNA synthesis and processing, and cytoplasmic mRNA turnover. A key step in mRNA degradation is the removal of the poly(A) tail, which involves several deadenylases including components of the Ccr4–Not complex.
Akhmed Aslam +2 more
exaly +6 more sources
hCAF1/CNOT7 regulates interferon signalling by targeting STAT1 [PDF]
EMBO Journal, 2013 Stringent regulation of the interferon (IFN) signalling pathway is essential for maintaining the immune response to pathogens and tumours. The transcription factor STAT1 is a crucial mediator of this response. Here, we show that hCAF1/CNOT7 regulates class I and II IFN pathways at different crucial steps.
Muriel Le Romancer +2 more
exaly +5 more sources
CNOT7 Outcompetes Its Paralog CNOT8 for Integration into The CCR4-NOT Complex
Journal of Molecular Biology, 2022 The CCR4-NOT deadenylase complex is a major post-transcriptional regulator of eukaryotic gene expression. CNOT7 and CNOT8 are both vertebrate homologs of the yeast CCR4-NOT catalytic subunit Caf1. They are highly similar and are sometimes considered redundant, but Cnot7 and Cnot8 knockout mice exhibit different phenotypes, implying distinct ...
Akiko Yanagiya +2 more
exaly +3 more sources
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CNOT7 modulates biological functions of ovarian cancer cells via AKT signaling pathway
Life Sciences, 2021CNOT7 plays an important role in many biological processes, providing attractive opportunities for the treatment of malignant tumors. However, the functions and mechanism of CNOT7 in ovarian cancer (OC) have not been elucidated. The purpose of this study was to assess the role of CNOT7 in OC.SKOV3 and A2780 cells were chosen as the cell lines for the ...
Jiangtao Yu, Xiuxiu Chen, Qi Jiang
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Oncogenic Gene CNOT7 Promotes Progression and Induces Poor Prognosis of Glioma
Molecular BiotechnologyAbstract Glioma is the most common malignant brain tumor in the central nervous system with the poor prognosis of patients. The CNOT7 (CCR4-NOT Transcription Complex Subunit 7) is an important functional subunit of CCR4-NOT protein complex that has not been reported in glioma. In this study, we aimed to explore the function of CNOT7 in glioma.
De Wei, Lin Kun
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Cnot7-Null Mice Exhibit High Bone Mass Phenotype and Modulation of BMP Actions
Journal of Bone and Mineral Research, 2007 Abstract Cnot7 is a recently identified regulator of spermatogenesis in adult mice. Because Cnot7 binds to Tob, a BMP inhibitor shown to be involved in bone metabolism, we examined whether Cnot7 is involved in bone mass regulation by using adult Cnot7 deficient mice. Cnot7−/− mice exhibited a high bone mass phenotype.
Takahisa Nakamura +2 more
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CNOT7 regulates lipid deposition in nonalcoholic fatty liver disease
Biochemical and Biophysical Research CommunicationsIn recent years, the incidence rate of nonalcoholic fatty liver disease (NAFLD) has ascended with the increasing number of metabolic diseases such as obesity and diabetes, which will bring great medical burden to society. At present, multiple scientific experiments have found that the CCR4-NOT complex can participate in regulating obesity and energy ...
Tiancai Liu, Weiheng Wen
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Oligo-astheno-teratozoospermia in mice lacking Cnot7, a regulator of retinoid X receptor beta [PDF]
Nature Genetics, 2004 Spermatogenesis is a complex process that involves cooperation of germ cells and testicular somatic cells. Various genetic disorders lead to impaired spermatogenesis, defective sperm function and male infertility. Here we show that Cnot7(-/-) males are sterile owing to oligo-astheno-teratozoospermia, suggesting that Cnot7, a CCR4-associated ...
Takahisa Nakamura +2 more
exaly +3 more sources