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Clinical advances of RNA therapeutics for treatment of neurological and neuromuscular diseases
RNA Biology, 2022 RNA therapeutics comprise a diverse group of oligonucleotide-based drugs such as antisense oligonucleotides (ASOs), small interfering RNAs (siRNAs), and short hairpin RNAs (shRNAs) that can be designed to selectively interact with drug targets currently ...
Anja Holm +3 more
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Indian Journal of Pathology and Microbiology, 2022 The latest fifth edition of the World Health Organization classification of central nervous system tumors (WHO CNS5) has been built on the prior WHO 2016 classification as well as recommendations put forward by seven updates of the Consortium to Inform ...
Swati Mahajan +4 more
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Lyme neuroborreliosis. Pathophysiological and diagnosis aspects [PDF]
Romanian Journal of Neurology, 2009 Lyme neuroborreliosis is the neurological complication of Borrelia burgdorferi infection. The main mechanism involved is acute inflammation (direct infectious or indirect autoimmune) leading to degeneration of the central and peripheral nervous system ...
Andreea Barsan +4 more
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Features of nervous system damage in antiphospholipid syndrome
Акушерство, гинекология и репродукция, 2021 Antiphospholipid syndrome (APS) is an autoimmune process that increases the risk of arterial and venous thrombosis. The mechanism of damage to the central nervous system (CNS) can be not only due to thrombosis, but also antiphospholipid antibodies (APA ...
O. N. Voskresenskaya +10 more
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Astrocyte and Oligodendrocyte Cross-Talk in the Central Nervous System
Cells, 2020 Over the last decade knowledge of the role of astrocytes in central nervous system (CNS) neuroinflammatory diseases has changed dramatically. Rather than playing a merely passive role in response to damage it is clear that astrocytes actively maintain ...
Erik Nutma +3 more
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Türk Patoloji Dergisi, 2022 In our manuscript, we propose a common terminology in the Turkish language for the newly adopted WHO classification of the CNS tumors, also known as the WHO CNS 5th edition. We also comment on the applicability of this new scheme in low and middle income
Figen SOYLEMEZOGLU +8 more
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Opioid toxicity due to CNS depressant polypharmacy: A case report [PDF]
Mental Health Clinician, 2021 The interaction between methadone and central nervous system depressants can cause serious adverse effects, including profound sedation, respiratory depression, coma, and death.
Christine Lee +4 more
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Orbital and brain metastases on 68Ga-PSMA PET/CT in a patient with prostate carcinoma refractory to 177Lu-PSMA and 225Ac-PSMA therapy [PDF]
Asia Oceania Journal of Nuclear Medicine and Biology, 2021 We present a case of metastatic prostate cancer with rare metastases involving the brain and orbit, in addition to liver, skeletal and nodal metastases. The patient had undergone prior hormonal therapy and chemotherapy and had disease progression despite
Ashwin Singh Parihar +4 more
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Current Hematologic Malignancy Reports, 2014 Primary diffuse large B-cell lymphoma (DLBCL) of the central nervous system is an aggressive malignancy that exhibits unique biological features and characteristic clinical behaviour, with overall long-term survival rates of around 20-40%. Clinical outcome has improved following the advent of chemoradiation protocols incorporating high-dose ...
Phillips, EH, Fox, CP, Cwynarski, K
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Communications Biology, 2023 Aerobic exercise effectively ameliorates mental disorders including anxiety and depression. Current findings mainly attribute its neural mechanism to the improvement of adult neurogenesis, while leaving the possible circuitry mechanism unclear.
Zhihua Luo +4 more
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