Results 71 to 80 of about 986,167 (302)

Cyclopentenyl ethylamines active on CNS [PDF]

, 1992
Two new cyclopentenylethylamines were prepared and were submitted to a pharmacological screening together with some others previously described and now reprepared. All compounds exhibited different degrees of depressive activity on CNS and good analgesic
Dimich, P.M., Moretti, Mario Domenico Luigi, Mulè, Antonio Calogero, Peana, Alessandra Tiziana, Pirisino, Gerolamo Antonio, Satta, Margherita, Sparatore, Fabio   +6 more
core  

Pregabalin: a range of misuse-related unanswered questions [PDF]

, 2019
© 2019 The Authors.
Chiappini, Stephania, Schifano, Fabrizio
core   +2 more sources

Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion

Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana, Mariana Maschietto, Daniela Paz Leal, Ricardo de Santos de Oliveira, Mayara Ferreira Euzébio, Antonio Carlos dos Santos, Luciano Neder, Carlos Alberto Scrideli, Elvis Terci Valera   +8 more
wiley   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Treadmill exercise prevents stress-induced anxiety-like behaviors via enhancing the excitatory input from the primary motor cortex to the thalamocortical circuit

Nature Communications
Physical exercise effectively prevents anxiety disorders caused by environmental stress. The neural circuitry mechanism, however, remains incomplete. Here, we identified a previously unrecognized pathway originating from the primary motor cortex (M1) to ...
Zhihua Luo, Junlin Chen, Yuchu Liu, Yelin Dai, Hui Gao, Borui Zhang, Haibin Ou, Kwok-Fai So, Ji-an Wei, Li Zhang   +9 more
doaj   +1 more source

Profiling the mouse brain endothelial transcriptome in health and disease models reveals a core blood-brain barrier dysfunction module. [PDF]

, 2019
Blood vessels in the CNS form a specialized and critical structure, the blood-brain barrier (BBB). We present a resource to understand the molecular mechanisms that regulate BBB function in health and dysfunction during disease.
Aydin, Sidar, Batugal, Austin, Cabangcala, Anne Christelle, Daneman, Richard, Gimlin, Kayleen, Hashimoto, Tomoki, Korai, Masaaki, Kotoda, Masakazu, Munji, Roeben Nocon, Noble-Haeusslein, Linda J, Oldham, Michael Clark, Schupp, Patrick Georg, Semple, Bridgette Deanne, Sohet, Fabien, Soung, Allison Luen, Trivedi, Alpa, Weiner, Geoffrey Aaron   +16 more
core   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

A Stronger Soft-Covering Lemma and Applications

, 2015
Wyner's soft-covering lemma is a valuable tool for achievability proofs of information theoretic security, resolvability, channel synthesis, and source coding.
Cuff, Paul
core   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Effects of tACS-Like Electrical Stimulation on Correlated Firing of Retinal Ganglion Cells: Part III

Eye and Brain, 2022
Franklin R Amthor, Christianne E Strang Department of Psychology, The University of Alabama at Birmingham, Birmingham, AL, 35294, USACorrespondence: Franklin R AmthorDepartment of Psychology, The University of Alabama at Birmingham, 1300 University Blvd,
Amthor FR, Strang CE
doaj