Results 81 to 90 of about 986,167 (302)

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Small Molecule Cocktail DLC79 Suppresses Gliomagenesis by Activating Ascl1 and Remodeling Transcriptome

Cells
Glioblastoma (GBM) remains incurable due to its invasive growth and therapeutic resistance. While the neurogenic transcription factor-mediated reprogramming of glioma cells has been reported, pharmacological reprogramming offers a promising alternative ...
Chuxiao Mao, Zhancheng Deng, Zhuming Chen, Lirong Huang, Caiyun Wang, Gong Chen, Qingsong Wang   +6 more
doaj   +1 more source

Intrathecal or Intraventricular Tigecycline Therapy for Central Nervous System Infection Associated with Carbapenem-Resistant Klebsiella pneumoniae

Infection and Drug Resistance, 2022
Ning Du,1 En-Qiang Mao,2 Zhi-Tao Yang,2 Hong-Ping Qu,3 Xian Qian,4 Ying Shi,5 Xiao-Lan Bian,6 Juan He,6,* Er-Zhen Chen2,* 1National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of
Du N, Mao EQ, Yang ZT, Qu HP, Qian X, Shi Y, Bian XL, He J, Chen EZ   +8 more
doaj  

The Transcriptional Aftermath in Two Independently Formed Hybrids of the Opportunistic Pathogen Candida orthopsilosis

mSphere, 2020
Interspecific hybridization can drive evolutionary adaptation to novel environments. The Saccharomycotina clade of budding yeasts includes many hybrid lineages, and hybridization has been proposed as a source for new pathogenic species.
Hrant Hovhannisyan, Ester Saus, Ewa Ksiezopolska, Toni Gabaldón   +3 more
doaj   +1 more source

Combination Therapy With Fingolimod and Neural Stem Cells Promotes Functional Myelination [PDF]

, 2019
Myelination, which occurs predominantly postnatally and continues throughout life, is important for proper neurologic function of the mammalian central nervous system (CNS).
Ciric, Bogoljub, Li, Xing, Lu, Xin-Yu, Ma, Cun-Gen, Rostami, A. M., Ye, Ze-Qin, Zhang, Guang-Xian, Zhang, Yuan   +7 more
core   +1 more source

Increase in neuroexcitability of unmyelinated C-type vagal ganglion neurons during initial postnatal development of visceral afferent reflex functions [PDF]

, 2013
BACKGROUND: Baroreflex gain increase up closely to adult level during initial postnatal weeks, and any interruption within this period will increase the risk of cardiovascular problems in later of life span. We hypothesize that this short period after
Cao, Pan‐Xiang, Han, Li‐Min, Li, Bai‐Yan, Li, Jun‐Nan, Liu, Dong‐Jie, Liu, Yang, Lu, Xiao‐Long, Pan, Xiao‐Dong, Qian, Zhao, Qiao, Guo‐Fen, Wang, Hao‐Yan, Wang, Li‐Juan, Xu, Bing, Yuan, Mei   +13 more
core   +2 more sources

Fluid and Neuroimaging Biomarkers in Microgliopathy Colony‐Stimulating Factor‐1 Receptor‐Related Disorders

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aims to identify both fluid and neuroimaging biomarkers for CSF1R‐RD that can inform the optimal timing of treatment administration to maximize therapeutic benefit, while also providing sensitive quantitative measurements to monitor disease progression.
Tomasz Chmiela, Madison Reeves, Karen Jansen‐West, Judith Dunmore, Yuping Song, Audrey Strongosky, Sunil Gandhi, Gilana Pikover, Matt Blurton‐Jones, Robert C. Spitale, Erik H. Middlebrooks, Leonard Petrucelli, Mercedes Prudencio, Zbigniew K. Wszolek   +13 more
wiley   +1 more source

Lymphatic drainage of the brain in extreme arterial hypertension

Бюллетень сибирской медицины, 2010
In the experiment on rabbits were presents, that experimental arterial hypertension didn’t led to functional failure of lymphatic drainage of brain. On the background of beta-blocker obzidan use failure liquor outflow from brain took place.
Ya. M. Pesin, Yu. I. Borodin, A. A. Beiseembayev, N. K. Omorov   +3 more
doaj   +1 more source

Prognostic Implications of Sleep Architecture for Patients Admitted to the Intensive Care Unit With Status Epilepticus

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Status epilepticus (SE) is associated with significant mortality. Sleep architecture may reflect normal brain function. Impaired sleep architecture is associated with poorer outcomes in numerous conditions. Here we investigate the association of sleep architecture in continuous EEG (cEEG) with survival in SE.
Ran R. Liu, Marcus C. Ng, Gavin P. Winston, Sabrina Schaly, Garima Shukla, Lysa Boissé Lomax   +5 more
wiley   +1 more source

Stress increases hepatic release of lipocalin 2 which contributes to anxiety-like behavior in mice

Nature Communications
Chronic stress induces anxiety disorders via both neural pathways and circulating factors. Although many studies have elucidated the neural circuits involved in stress-coping behaviors, the origin and regulatory mechanism of peripheral cytokines in ...
Lan Yan, Fengzhen Yang, Yajie Wang, Lingling Shi, Mei Wang, Diran Yang, Wenjing Wang, Yanbin Jia, Kwok-Fai So, Li Zhang   +9 more
doaj   +1 more source