Results 31 to 40 of about 769,092 (333)

Impaired platelet function in Hermansky-Pudlak syndrome associated with novel mutations in HPS3, HPS6 and HPS8 genes

Bleeding, Thrombosis and Vascular Biology
We report three unrelated cases of Hermansky-Pudlak (HP) characterized by novel mutations in HPS3 (compound heterozygosity for c.1457G>A and c.1813G>T), HPS6 (homozygous c.210_211insGGGCC), and HPS8 (homozygous c.299dupC in BLOC1S3) genes.
Lisa Pieri, Silvia Linari, Francesca Salvianti, Monica Attanasio, Giancarlo Castaman   +4 more
doaj   +1 more source

Catalytic coagulation

Physical Review E
We introduce an autocatalytic aggregation model in which the rate at which two clusters merge to form a cluster is controlled by the presence of a third "catalytic" cluster whose mass must equal to the mass of one of the reaction partners. The catalyst is unaffected by the joining event and is available to either participate in or catalyze subsequent ...
P. L. Krapivsky, S. Redner
openaire   +3 more sources

Phase transition of the one-dimensional coagulation-production process

, 2000
Recently an exact solution has been found (M.Henkel and H.Hinrichsen, cond-mat/0010062) for the 1d coagulation production process: 2A ->A, A0A->3A with equal diffusion and coagulation rates. This model evolves into the inactive phase independently of the
E. Carlon, G. Mennon, G. Szabó, G. Ódor, G. Ódor, G. Ódor, G. Ódor, G. Ódor, Géza Ódor, H. A. Gutowitz, H. Hinrichsen, H. Hinrichsen, H. Hinrichsen, H. Hinrichsen, H. K. Janssen, I. Jensen, M. Henkel, M. J. Howard, M. Suzuki, N. Menyhárd, N. Menyhárd, P. Grassberger, P. Grassberger, R. Dickman, S. Kwon   +24 more
core   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Coagulation and non‐coagulation effects of thrombin [PDF]

Journal of Thrombosis and Haemostasis, 2016
Thrombin is a multifunctional serine protease produced from prothrombin, and is a key regulator in hemostatic and non-hemostatic processes. It is the main effector protease in primary hemostasis by activating platelets, and plays a key role in secondary hemostasis.
Posma, J. J. N., Posthuma, J. J., Spronk, H. M. H.   +2 more
openaire   +2 more sources

Charging and Growth of Fractal Dust Grains

, 2007
The structure and evolution of aggregate grains formed within a plasma environment are dependent upon the charge acquired by the micron-sized dust grains during the coagulation process.
Hyde, Truell W., Matthews, Lorin S.
core   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Acute Myeloid Leukemia With NPM1 Mutation Presenting With Rapidly Progressing Hypereosinophilia

Case Reports in Hematology
Hypereosinophilia presents a significant clinical challenge. We describe a case of severe, rapidly progressing hypereosinophilia, with the white blood cell count increasing from 40,000/μL to over 130,000/μL within days, and 70% eosinophils on ...
S. Einarsdottir, G. Orrsjö, L. von Bahr, A. Staffas, L. Fogelstrand   +4 more
doaj   +1 more source

Translation and Cultural Adaptation of the ISTH-Bleeding Assessment Tool to European Portuguese

Acta Médica Portuguesa
Introduction: A distinctive bleeding history is the first diagnostic stage of congenital hemorrhagic diseases. Furthermore, since it is in fact an assessment of the patient’s phenotype, it is not a (mere) complementary diagnostic method or test - it is ...
Diana Carneiro-Leão, Sofia Teixeira, Rita Queirós Pereira, Teresa Mota, Manuela Lopes, Susana Nobre-Fernandes, Fernando Araújo   +6 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source