Results 71 to 80 of about 316,307 (295)

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Fine-mapping and primary analysis of candidate genes associated with seed coat color in mung bean (Vigna radiata L.)

Journal of Integrative Agriculture
Seed coat color affects the appearance and commodity quality of mung beans (Vigna radiata L.). The substances that affect mung bean seed coat color are mainly flavonoids, which have important medicinal value.
Qian Wang, Huimin Cao, Jingcheng Wang, Zirong Gu, Qiuyun Lin, Zeyan Zhang, Xueying Zhao, Wei Gao, Huijun Zhu, Hubin Yan, Jianjun Yan, Qingting Hao, Yaowen Zhang   +12 more
doaj   +1 more source

Digestibilidad de las proteinas de frijol factores reguladores [PDF]

, 2016
The low digestibility of grain legumes, particularly beans, is highlighted and its regulating factors (tannins, seed coat fiber, protease inhibitors, protein structure of the protein to digest, interactions between proteins and other cotyledon nutrients,
Lareo, LR
core  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Evaluating the effect of light exposure and seed coat on lentil cotyledon color by computer vision

Legume Science, 2021
A computer vision system and color analysis algorithms were employed to study the influence of UVA (ultraviolet‐A) and visible light on the color of lentils with red, green, and yellow cotyledons. Twenty samples of cotyledons from each of the three‐color
Nsuhoridem Jackson, Scott D. Noble, Albert Vandenberg   +2 more
doaj   +1 more source

Infrared light extinction by charged dielectric core-coat particles

, 2014
We study the effect of surplus electrons on the infrared extinction of dielectric particles with a core-coat structure and propose to use it for an optical measurement of the particle charge in a dusty plasma.
Bronold, Franz X., Fehske, Holger, Heinisch, Rafael L., Thiessen, Elena   +3 more
core   +1 more source

Studies of ecomorphological variations of the European hare (Lepus europaeus) in Turkey [PDF]

, 2013
Hares (Lepus spp.) are widely distributed across the globe and are adapted to diverse climatic conditions. In order to study the ecomorphological variations of hares from Turkey, the body and cranial measurements and body weight, as well as coat color
Albayrak İ., Demirbaş Y., Yilmaz A.
core   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source