Results 91 to 100 of about 118,464 (297)
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Analysis of Genetic Basis of the Red Coat Colour of Crossbred of Duroc and Ding'an Pig
Guangdong nongye kexue【Objective】The melanocortin 1 receptor (MC1R) plays a critical role in mammalian pigmentation and coat color formation. Different MC1R alleles are associated with various coat color patterns in pigs.
Sitong ZHU +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
PLoS ONE, 2010 BackgroundCongenital sensorineural deafness is an inherited condition found in many dog breeds, including Australian Stumpy-tail Cattle Dogs (ASCD). This deafness is evident in young pups and may affect one ear (unilateral) or both ears (bilateral).
Susan Sommerlad +6 more
doaj +1 more source
The Accessible Toilet Design Resource [PDF]
, 2007 This Accessible Toilet Design Resource has been produced from new primary research carried out within VivaCity 2020, a large university-based research consortium that is developing tools and resources to support the design of socially inclusive cities ...
Bichard, Jo-Anne +2 more
core
Molecular genetics of coat colour in pigs
Acta agriculturae Slovenica. Suplement, 2013 Coat colour in Sus scrofa has been the matter of pioneering genetics studies carried out at the beginning of the last century. Since then, classical genetics studies have assumed that several loci affect this trait in pigs. With the advent of molecular genetics it was possible to identify genes and mutations affecting coat colours and patterns in pigs.
FONTANESI, LUCA, RUSSO, VINCENZO
openaire +3 more sources
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Effect of skin and coat characteristics on growth and milk production traits in Tharparkar cattle
Indian Journal of Animal Sciences, 2019 The present study was conducted on a total of 68 Tharparkar cattle (Bos indicus) at Cattle and Buffalo farm (Indian Veterinary Research Institute) from December 2016 to April 2017.
SOFI AAQIB RASHID +4 more
doaj +1 more source
Colour change and assortment in the western rainbowfish [PDF]
, 2010 Grouping behaviour is widespread across the animal kingdom, and is known to reduce an individual's risk of predation, for example through predator confusion.
Kelley, Jennifer L. +2 more
core +1 more source