Results 111 to 120 of about 19,836 (289)

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

open access: yesFEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke   +4 more
wiley   +1 more source

Molecular genetics and mechanisms of pigmentation and melanoma [PDF]

open access: yes, 2010
Ever since man domesticated the first wild animals several thousand years ago, many species have been living in close relationship with humans, being objects for our requests and wishes about any kind of phenotypic traits.
Sundström, Elisabeth
core  

On the inheritance of coat colour in horses [PDF]

open access: yesProceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character, 1906
Abstract Recent experiments by the writer have demonstrated the Mendelian inheritance of coat colour in rabbits. These results suggested that the inheritance of coat colour in horses might also be in accordance with the Mendelian principles. In the case of horses, however, the ordinary method of direct experiment was impracticable, so
openaire   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Identification of candidate coat colour determining genes in Hortobágy Racka sheep using RNA-seq

open access: yes
Domestic sheep (Ovis aries) have been a part of people’s lives for millennia and are still globally kept as farm animals for their relatively easy keeping and multipurpose utilisation.
Sárkány, Péter
core  

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

open access: yesFEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho   +4 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

A note on the inheritance of the “steel” coat-colour in rabbits [PDF]

open access: yesJournal of Genetics, 1922
1. The peculiar ticking which causes the coat pattern known as “steel” in Dutch rabbits may be represented as a heterozygous character. 2. The factor for this character, calledX, may be considered as a darkening or melanising factor, similar toD in the “agouti-blacks” of Punnett, but rather weaker in its effect.
openaire   +1 more source

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