Results 91 to 100 of about 19,836 (289)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

First documented observation of differential dorsoventral coat colouration in wild boar Sus scrofa (Artyodactyla: Suidae) in Italy

Natural History Sciences
Wild boar Sus scrofa usually shows a uniform brown coat, but different colour patterns have been observed with red, brown, black, and white morphs. Nevertheless, coat colour polymorphism is often associated with hybridization with domestic pigs.
Francesco Gallozzi
doaj   +1 more source

Hair coat characteristics in Friesian heifers in the Netherlands and Kenya : experimental data and a review of literature

, 1978
The export of about 2600 Friesian heifers to Kenya between 1971-1973 provided an opportunity of studying the adaptation problems experienced by these heifers.
Udo, H.M.J.
core  

Identification of potential porcine coat colour gene markers

, 2016
Coat colour gene variants, such as MC1R and KIT alleles, are successfully used to characterize livestock breeds and ...
Carmen Barragán, Carmen Barragán (422673), Jose Luis Noguera, Yolanda Nuñez, Jose Luis Noguera (4925842), Luis Silió (422676), Cristina Óvilo, Luis Silió, Yolanda Nuñez (5296192), Armand Sánchez (3324795), Almudena Fernández, Armand Sánchez, Carmen Rodríguez (2228080), Carmen Rodríguez, Ana I Fernández, Anixa Muiñoz-Buhl, Cristina Óvilo (422675), Ana I Fernández (5296198), Anixa Muiñoz-Buhl (5296195), Almudena Fernández (422672)   +19 more
core   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Coat colour in horses

, 2011
Özet: Bu çalışmada atlarda çeşitli donları incelenmiştir. Atın vücut rengine Türkçede don adı verilir. Don, sadece atseverler ve yetiştiricileri için değil, aynı zamanda bilim insanları için de her zaman bir çekim kaynağı olmuştur.
Yılmaz, Orhan, Ertuğrul, Mehmet
core  

Clinical evaluation of the new coat colour macchiato in a male Franches-Montagnes horse

, 2013
In April 2008 a Franches-Montagnes colt was born with an unusual coat colour phenotype which had never been observed in that population before. The foal showed extended white markings on body and legs, a white head and blue eyes.
Rieder, S., Burger, D, Janett, F., Leeb, T, Haase, B, Gerber, V, Poncet, P.-A., Henke, D, Poncet, P A, Blatter, Marlis, Leeb, Tosso, Rieder, S, Gerber, Vinzenz, Burger, Dominik, Henke, Diana, Blatter, M, Janett, F, Haase, Bianca   +17 more
core   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Frequencies of genes for coat colour and horns in Nordic cattle breeds

Genetics Selection Evolution, 2000
Gene frequencies of coat colour and horn types were assessed in 22 Nordic cattle breeds in a project aimed at establishing genetic profiles of the breeds under study. The coat colour loci yielding information on genetic variation were: extension, agouti,
Lien Sigbjørn, Holm Lars-Erik, Eythorsdottir Emma, Brusgaard Klaus, Olsaker Ingrid, Kantanen Juha, Danell Birgitta, Adalsteinsson Stefan   +7 more
doaj   +1 more source