Results 91 to 100 of about 1,339,183 (353)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

The effects of carboxylic acids in aluminum anodizing [PDF]

, 2017
Hard-anodized alumina coatings were formed in sulfuric acid at low temperature and high current density in the presence of carboxylic acid additives. Citric acid, trimesic acid, mellitic acid and ethylenediaminetetraacetic acid (EDTA) were utilized in ...
Koczera, Abby E
core   +1 more source

Hydroxyapatite coating on titanium by a low energy plasma spraying mini-gun [PDF]

, 2012
Plasma-sprayed hydroxyapatite (HA) coatings are used on metallic implants to improve osseointegration and bone growth. The purpose of this work was to determine the microstructure and composition of HA coatings obtained with a newly developed low energy ...
Barykin, George, Braceras, Inigo, Combes, Christèle, Demnati, Imane, Drouet, Christophe, Fagoaga, Ignacio, Gonçalvès, Stéphane, Grossin, David, Parco, Maria, Rey, Christian   +9 more
core   +2 more sources

Laser Dissimilar Joining of Al7075T6 with Glass-Fiber-Reinforced Polyamide Composite [PDF]

, 2020
Dissimilar joining between metal and composite sheets is usually carried out by mechanical or adhesive joining. Laser dissimilar joining between metal and composite sheets could be an alternative to these methods, as it is a cost-effective and versatile ...
Andres, Maite, Arrizubieta, Jon Iñaki, Ferros, Mercedes, Liebana, Fernando, Ukar, Eneko   +4 more
core   +4 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Drug Distribution and Stent Retention of Drug Eluting Stents [PDF]

, 2008
In this paper the examinations of drug eluting coronary stents are shown, such as the morphology of the coatings before expansion, drug distribution, the methodology and the value of stent retention.
Balázs, T., Bognár, Eszter, Dobránszky, János, Ring, Gy.   +3 more
core  

Comparison of single-layer and double-layer anti-reflection coatings using laser-induced damage threshold and photothermal common-path interferometry [PDF]

, 2016
The dielectric thin-film coating on high-power optical components is often the weakest region and will fail at elevated optical fluences. A comparison of single-layer coatings of ZrO2, LiF, Ta2O5, SiN, and SiO2 along with anti-reflection (AR) coatings ...
Bassiri, Riccardo, Clark, Caspar, Fejer, Martin, Gibson, Des, Markosyan, Ashot, Martin, Iain W., Murray, Peter G., Rowan, Sheila   +7 more
core   +2 more sources

Bio-inspired hydrogels as multi-task anti-icing hydrogel coatings [PDF]

, 2020
In a recent report in Matter, Zhu, Wang, He and co-workers report a straightforward and effective strategy for the design of icephobic hydrogel coatings on the basis of polydimethylsiloxane (PDMS)-grafted polyelectrolyte hydrogels.
Hoogenboom, Richard, Jerca, Valentin-Victor, Xu, Xiaowen   +2 more
core   +2 more sources

Coating and Pharmacokinetic Evaluation of Air Spray Coated Drug Coated Balloons [PDF]

Cardiovascular Engineering and Technology, 2018
Drug coated balloons (DCB) are becoming the standard-care treatment for peripheral arterial disease (PAD). DCB use excipients to transfer and retain anti-proliferative drugs, such as paclitaxel. Excipients thus play a vital role in the design and function of DCB, however methods to coat balloons with excipients and anti-proliferative drugs remain ...
Emily A. Turner, Marzieh K. Atigh, Megan M. Erwin, Uwe Christians, Saami K. Yazdani   +4 more
openaire   +2 more sources

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source