Results 41 to 50 of about 106,004 (265)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Coating and Pharmacokinetic Evaluation of Air Spray Coated Drug Coated Balloons [PDF]

Cardiovascular Engineering and Technology, 2018
Drug coated balloons (DCB) are becoming the standard-care treatment for peripheral arterial disease (PAD). DCB use excipients to transfer and retain anti-proliferative drugs, such as paclitaxel. Excipients thus play a vital role in the design and function of DCB, however methods to coat balloons with excipients and anti-proliferative drugs remain ...
Emily A. Turner, Marzieh K. Atigh, Megan M. Erwin, Uwe Christians, Saami K. Yazdani   +4 more
openaire   +2 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Approximation of the Profile of Gas Turbine Engine Blades

Advanced Engineering Research
Introduction. Increasing the durability of gas turbine engine (GTE) blades is achieved through the use of special protective coatings on their surface.
M. E. Soloviev, Y. N. Shuleva, S. L. Baldaev, L. Kh. Baldaev   +3 more
doaj   +1 more source

The structure and properties of pre-alloyed NiAl-Cr(Co,Hf) spherical powders produced by plasma rotating electrode processing for additive manufacturing

Journal of Materials Research and Technology, 2018
The structure and properties of pre-alloyed Ni41Al41Cr12Co6 spherical powders (the 40–160 μm fraction) produced using the plasma rotating electrode processing technology were studied.
Yu.Yu. Kaplanskii, A.A. Zaitsev, Zh.A. Sentyurina, E.A. Levashov, Yu.S. Pogozhev, P.A. Loginov, I.A. Logachev   +6 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

The Impact of Electrolytic Cell Parameters on the Boiling Rate of the Electrolyte During Electrolytic Plasma Processing

Computation
This study investigates the influence of electrolytic cell parameters on the electrolyte boiling rate during electrolytic plasma processing, a critical stage for plasma formation and subsequent surface modification.
Rinat Kurmangaliyev, Yeldos Mukhametov, Bauyrzhan Rakhadilov, Rinat Kussainov, Nurlat Kadyrbolat   +4 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Influence of Mg and Al alloying additions on the corrosion mechanisms of Hot-dipped Zn-Mg-Al coatings: role of microstructure and phase distribution

npj Materials Degradation
Systematic investigations into the individual effects of increasing alloying additions of Mg and Al on the corrosion mechanisms of Zn-Mg-Al coatings have demonstrated that microstructural phases and their surface distribution determine the anodic and ...
A. D. Malla, G. Williams, D. A. Britton, F. E. Goodwin, Ana P. Domingos Cardoso, T. Richards, D. J. Penney, J. H. Sullivan   +7 more
doaj   +1 more source

Efficient Flexible All-Solid Supercapacitors with Direct Sputter-Grown Needle-Like Mn/MnO_x@Graphite-Foil Electrodes and PPC-Embedded Ionic Electrolytes

Nanomaterials, 2020
Recent critical issues regarding next-generation energy storage systems concern the cost-effective production of lightweight, safe and flexible supercapacitors yielding high performances, such as high energy and power densities as well as a long cycle ...
Apurba Ray, Delale Korkut, Bilge Saruhan
doaj   +1 more source